Summary
This paper will review experiments designed to study mechanisms of nicotine-induced acute tolerance in two behavioral models, nicotine-induced discriminative stimulus (DS) control of behavior, and nicotine-induced disruption of operant behavior. Acute tolerance to nicotine in both paradigms was explained on the basis that nicotine was able to induce a desensitization of nicotinic cholinergic receptors leading to an attenuation of nicotine’s effects.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Rosecrans JA. Nicotine as a discriminative stimulus: A neurobiological approach to studying central cholinergic mechanisms. J Subs Abuse 1989; 1: 287–300.
Rosecrans JA, Karan LD. Neurobehavioral mechanisms of nicotine action: Role in the initiation and maintenance of tobacco dependence. J Subs Abuse Treat 1993; 10: 161–170.
Meltzer LT, Rosecrans, JA. Nicotine and arecoline as discriminative stimuli: Involvement of noncholinergic mechanisms for nicotine. Pharmacol Biochem Behav 1988; 29: 587–593.
Wonnocott S. The paradox of nicotinic acetylcholine receptor upregulation. Trend Pharmacol Sci 1990; 11: 216–219.
James JR, Villanueva HF, Johnson JH Arezo S, Rosecrans JA. Evidence that nicotine can acutely desensitize central nicotinic acetylcholinergic receptors. Psychopharmacology 1994; 114: 456–462.
Villanueva HF, Arezo S, James JR, Rosecrans JA. A characterization of nicotine-induced tolerance: Evidence of pharmacological tolerance in the rat. Behav Pharmacol 1992; 3: 255–260.
Marks MJ, Burch JB, Collins AC. Effects of chronic nicotine infusion on tolerance development an nicotinic receptors. J Pharmacol Exp Therap 1985; 22: 81–825.
Nordberg A, Wahlstrom G, Arnelo U, Larrson C. Effects of long-term nicotine treatment on [’H]nicotine binding sites in the rat brain. Drug Ale Depend 1985; 16: 9–17.
Rosecrans JA, Wiley JL, Bass CE, Karan LD. Nicotine-induced acute tolerance: Studies involving schedule-controlled behavior. Brain Res Bull (in press).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Birkhäuser Verlag, Basel
About this chapter
Cite this chapter
Rosecrans, J.A., Karan, L.D., James, J.R. (1995). Nicotine as a Discriminative Stimulus: Individual Variability to Acute Tolerance and the Role of Receptor Desensitization. In: Clarke, P.B.S., Quik, M., Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems II. Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7445-8_28
Download citation
DOI: https://doi.org/10.1007/978-3-0348-7445-8_28
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-0348-7447-2
Online ISBN: 978-3-0348-7445-8
eBook Packages: Springer Book Archive