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Electrophysiology of Neuronal Nicotinic Receptors in the CNS

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Effects of Nicotine on Biological Systems II

Part of the book series: Advances in Pharmacological Sciences ((APS))

Summary

We have analyzed the properties of nicotinic acetylcholine receptors (nAChRs) in several regions of rat and mouse central nervous system. We have demonstrated the existence of several functionally distinct subtypes of nAChRs. A direct role of nAChR in synaptic transmission could not be found under our experimental conditions and in these preparations. However, we have shown that nAChRs acting at a preterminal (tetrodotoxin-sensitive) or at a presynaptic (tetrodotoxin-insensitive) level can modulate GABAergic synaptic transmission in several brain regions.

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Author information

Authors and Affiliations

  1. Laboratoire de Neurobiologie Moléculaire, URA CNRS D1284, Institut Pasteur, Paris, France

    Christophe Mulle, Clément Léna & Jean-Pierre Changeux

Authors
  1. Christophe Mulle
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  2. Clément Léna
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  3. Jean-Pierre Changeux
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, H3G 1Y6, Montreal, Québec, Canada

    Paul Brian Sydenham Clarke  & Maryka Quik  & 

  2. Stiftung für Verhalten und Umwelt, Pettenkoferstrasse 12, D-80336, München, Germany

    Franz Adlkofer (Sekretär) (Sekretär)

  3. Physiologisches Institut, Universität München, Pettenkoferstrasse 12, D-80336, München, Germany

    Klaus Thurau (Vorstand) (Vorstand)

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© 1995 Birkhäuser Verlag Basel

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Mulle, C., Léna, C., Changeux, JP. (1995). Electrophysiology of Neuronal Nicotinic Receptors in the CNS. In: Clarke, P.B.S., Quik, M., Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems II. Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7445-8_16

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  • DOI: https://doi.org/10.1007/978-3-0348-7445-8_16

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7447-2

  • Online ISBN: 978-3-0348-7445-8

  • eBook Packages: Springer Book Archive

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