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Presynaptic Nicotine-Gated Channels Potentiate Transmission at ACh and Glutamate-Mediated Synapses

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Effects of Nicotine on Biological Systems II

Part of the book series: Advances in Pharmacological Sciences ((APS))

Summary

Examination of specific cholinergic and glutamatergic synapses reveals that nanomolar concentrations of nicotine potentiate both spontaneous and evoked transmission. Analysis of miniature excitatory synaptic currents (mepsc) before and after synaptic application of nicotine indicates that presynaptic changes underlie the synaptic facilitation, since nicotine increases mepsc frequency by more than 10 fold without altering the amplitude of the unit mode of mepsc histograms. Image analysis of changes in presynaptic [Ca]int, as well as pharmacological and antisense-mediated nicotinic acetylcholine receptor (nAChR) subunit deletion experiments suggest that synaptic transmission is potentiated by direct activation of high affinity presynaptic nAChRs that include the α7 subunit.

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Author information

Authors and Affiliations

  1. Dept. of Cell Biology & Anatomy and The Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, 722 W 168th St., New York, N.Y., 10032, USA

    D. McGehee & L. W. Role

Authors
  1. D. McGehee
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  2. L. W. Role
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, H3G 1Y6, Montreal, Québec, Canada

    Paul Brian Sydenham Clarke  & Maryka Quik  & 

  2. Stiftung für Verhalten und Umwelt, Pettenkoferstrasse 12, D-80336, München, Germany

    Franz Adlkofer (Sekretär) (Sekretär)

  3. Physiologisches Institut, Universität München, Pettenkoferstrasse 12, D-80336, München, Germany

    Klaus Thurau (Vorstand) (Vorstand)

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© 1995 Birkhäuser Verlag Basel

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McGehee, D., Role, L.W. (1995). Presynaptic Nicotine-Gated Channels Potentiate Transmission at ACh and Glutamate-Mediated Synapses. In: Clarke, P.B.S., Quik, M., Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems II. Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7445-8_15

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  • DOI: https://doi.org/10.1007/978-3-0348-7445-8_15

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7447-2

  • Online ISBN: 978-3-0348-7445-8

  • eBook Packages: Springer Book Archive

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