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Butylated Hydroxytoluene Toxicity

  • Chapter
Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications

Part of the book series: Molecular and Cell Biology Updates ((MCBU))

Summary

The phenolic antioxidant butylated hydroxytoluene (BHT) causes toxic effects in experimental animals including hemorrhage, lung, liver and kidney injury, and tumor promotion. ADI values of 0–0.125 (WHO) and 0–0.05 (EEC) mg/kg body weight have been derived from toxicological animal studies. Two aspects of the possible toxic mechanisms are discussed: 1) BHT interferes with certain components of calcium homeostasis and signal transduction. This may contribute to its hemorrhagic action. 2) During BHT metabolism, reactive oxidized BHT products and reactive oxygen species are formed. Among these, BHT hydroperoxide and/or BHT quinone methide are involved in the toxic as well as in the tumor-promoting activity of BHT.

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Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology, University of Gottingen, Robert-Koch-Str. 40, W-3400, Gottingen, Germany

    R. Kahl

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  1. R. Kahl
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Editors and Affiliations

  1. Malaysian Palm Oil Promotion Council, Bangunan Getah Asli 148 Jalan Ampang, 50450, Kuala Lumpur, Malaysia

    A. S. H. Ong

  2. Dept. of Molecular and Cell Biology 251 Life Science Addition, Membrane Bioenergetics Group, Berkeley, California, 94720, USA

    L. Packer

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© 1992 Birkhäuser Verlag, Basel/Switzerland

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Kahl, R. (1992). Butylated Hydroxytoluene Toxicity. In: Ong, A.S.H., Packer, L. (eds) Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7432-8_47

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  • DOI: https://doi.org/10.1007/978-3-0348-7432-8_47

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7434-2

  • Online ISBN: 978-3-0348-7432-8

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