Summary
Japanese herbal medicine, Sho-saiko-to-go-keishi-kashakuyaku-to (TJ-960), scavenged hydroxyl radicals, superoxide and 1,1-diphenyl-2-picrylhydrazyl radicals. It also diminished carbon centered radicals generated by oxygen stress in the rat cortex homogenate and quenched alpha-tocopheroxyl radicals in rat mitochondria and microsomes of vitamin E supplemented rats. The carbon centered radicals and thiobarbituric acid reactive substances (TBARS) levels decreased in the aged rat brain after 3-week oral administration of 5% TJ-960 solution. TJ-960 elevated superoxide dismutase (SOD) activity in cytosol fraction of hippocampus and hypothalamus of aged animals. It decreased norepinephrine and 5-hydroxytryptamine (5-HT) levels in hypothalamus and increased 5-HT level in cerebellum. TJ-960 treatment increased choline acetyltransferase activity in aged rats. As herbal medicines do not generally have harmful side effects, TJ-960 appears as a suitable prophylactic agent against some neuronal symptoms of aging.
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References
Allen, S., Benton, J.S., Goodhardt, M.J., Haan, E.A., Sims, N.R., Smith, C.C.T., Spillane, J.A., Bowen, D.M. and Davison, A.N. (1983) J. Neurochem. 41, 256–265.
Cutler, R.G. (1991) Am. J. Clin. Nutr. 53, 373s–379s.
Cross, A.J., Crow, T.J., Perry, E.K., Perry, R.H., Blessed, G. and Tomlinson, B.E. (1981) Br.Med.J. 282, 93–94.
Dann, H.C., Benedetti, M.S. and Dostert, P. (1983) J. Neurochem. 40, 1003–1007.
De Quiroga, G.B., Perez-Campo R. and Lopezz Torres M.(1990) Biochem. J. 272, 247–250.
Estes, K.S. and Simpkins, J.W. (1980) Brain Res. 194, 556–560
Estes, K.S. and Simpkins, J.W. (1984) Brain Res. 298, 209–218.
Fonnum, F. (1974) J. Neurochem. 24, 407–409.
Fujita, K., Maruta, K., Teradaira, R., Beppu, H., Ikegame, M. and Kawai, K. (1982) Clin.Chem. 28, 1403–1404.
Geremia, E., Baratta, S.D., Zafarana, S., Giodarno, R., Pinizzotto, M.R., La Rosaa, M.D.G. and Garozzo, A. (1990) Neurochem. Res. 15, 719–723.
Glowinski, J. and Iversen, L.L. (1966) J. Neurochem. 13, 655–659.
Gottfries, C.G., Adolfsson, R., Aquilonius, S.M., Carlsson, A., Eckernas, S.A., Nordberg, A., Oreland, L., Svennerholm, L., Wiberg, A. and Winblad, B. (1983) Neurobiol.Aging 4, 261–271.
Gottfries, C.G., Roos, B.E. and Winblad, B. (1976) Aktuelle Gerontol. 6, 429–435.
Hardy, J., Adolfsson, R., Alafusoff, I., Bucht, G., Marcusson, J., Nyberg, P., Pedrahl, E., Wester, P. and Winblad, B. (1985) Neurochem. Int., 7, 545–563.
Haba, K., Ogawa, N., Kawata, M. and Mori, A. (1988) Neurochem. Res. 13, 951–955.
Haba, K., Ogawa, N., Kawata, M. and Mori, A. (1988) Neurochem. Res. 13, 488–492.
Hiramatsu, M., Kabuto, H. and Mori, A. (1988) In: Recent Advances in the Pharmacology of KAMPO (JAPANESE HERBAL) MEDICINES (E. Hosoya and Y. Yamamura, Eds), Excerpta Medica, pp. 69–73.
Hiramatsu, M., Edamatsu, R., Kohno, M. and Mori, A. (1988) In: Recent Advances in the Pharmacology of KAMPO (JAPANESES HERBAL) MEDICINES (E. Hosoya and Y. Yamamura Eds), Excerpta Medica, pp. 120–127.
Hiramatsu, M., Edamatsu, R., Kabuto, H. and Mori, A. (1988) In: Recent Advances in the Pharmacology of KAMPO (JAPANESE HERBAL) MEDICINES (E. Hosoya and Y. Yamamura, Eds), Excerpta Medica, pp. 128–135.
Hiramatsu, M., Haba, K., Edamatsu, R., Hamada, H. and Mori, A. (1989) Neurochem. Res. 14, 249–251.
Hiramatsu, M., Kabuto, H. and Mori, A. (1986) IRCS Med. Sci. 14, 189–190.
Hiramatsu, M. and Kohno, M. (1987) JEOL News 23A, 7.
Hiramatsu, M., Kohno, M., Edamatsu, R. and Mori, A. (1991) J. Neurochem. in press.
Hirschorn, I.D., Marman, M.H. and Sharpless, N.S. (1982) Brain Res. 234, 357–368.
Kellogg, E.W., BS, III and Fridovich, I. (1976) J. Gerontol. 31, 405–408.
Mavelli, I., Mondovi, B., Federico, R. and, Rotilio, G. (1978) J.Neurochem. 31, 363–364.
Ohishi, S. (1978) Saishin Igaku 33, 660–663.
Osterburg, H.H., Donahue, H.G., Severson, J.A. and Finch, C.E. (1981) Brain Res. 224, 337–352.
Perry, E.K., Blessed, G., Tomlinson, B.E., Perry, R.H., Crow, T.J., Cross, A.J., Dockray, G.J., Dimaline, R. and Arregui, A. (1981) Neurobiol. Aging 2, 251–256.
Sawada, M. and Carlson, J.C. (1987) Mechanisms of Aging and Development, 41, 125–137.
Simpkins, J.W., Mueller, G.P., Huang, H.H. and Meites, J. (1977) Endocrinology, 100, 1672–1678.
Sims, N.R., Marek, K.L., Bowen, D.M. and Davison, A.N. (1982) J. Neurochem. 38, 488–492.
Sugaya, E., Ishiga, A., Sekiguchi, K., Iizuka, S., Sugimoto, A., Yuzurihara, M. and Hosoya, E. (1988) Epilepsy Res. 2, 337–339.
Yates, C.M., Ritchie, I.M., Simpson, J., Maloney, A.F.J. and Gordon, A. (1981) Lancet ii 39–40.
Yates, C.M., Simpson, J., Gordon, A., Maloney, A.F.J., Allison, Y., Ritchie, I.M. and Urquhart, A. (1983) Brain Res. 280, 119–126.
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© 1992 Birkhäuser Verlag, Basel/Switzerland
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Hiramatsu, M., Edamatsu, R., Ohyama, H., Mori, A. (1992). Effect of Japanese Herbal Medicine, Sho-Saiko-To-Go-Keishi-Kashakuyaku-To (TJ-960) on Aging. In: Ong, A.S.H., Packer, L. (eds) Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7432-8_42
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DOI: https://doi.org/10.1007/978-3-0348-7432-8_42
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