Abstract
Phospholipid hydroperoxides (PLOOH) can be generated in membranes by different mechanisms: lipid peroxidation, lipoxygenase reaction and addition of singlet oxygen. Whilst singlet oxygen addition is a non radical reaction, leading directly to the hydroperoxide, the lipid peroxidation initiator (usually an iron-oxygen complex) and lipoxygenases produce first a carbon centered radical, which than reacts with oxygen. The reduction of lipid hydroperoxyl radicals to lipid hydroperoxides is part of the lipoxygenase reaction, without a specific requirement for hydrogen donors. On the other hand, phospholipid hydroperoxyl radicals (PLOO•) produced during lipid peroxidation can start a chain reaction, getting the hydrogen atom from a polyunsaturated fatty acid, which eventually contains a new carbon centered radical (1).
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© 1992 Birkhäuser Verlag, Basel/Switzerland
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Maiorino, M., Ursini, F. (1992). Synergistic Effect of Lipid Hydroperoxyl Radical Scavenging and Lipid Hydroperoxide Reduction in the Inhibition of Lipid Peroxidation in Biomembranes. In: Ong, A.S.H., Packer, L. (eds) Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7432-8_4
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DOI: https://doi.org/10.1007/978-3-0348-7432-8_4
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