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Effect of Different Antioxidants in Experimental Myocardial Infarction

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Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications

Part of the book series: Molecular and Cell Biology Updates ((MCBU))

Summary

Changes in metabolism of lipidperoxides was observed in rats in which myocardial infarction was induced by isoproterenol. The mortality rate in isoproterenol treated animals were high (35% to 40%). Histopathological examination of the heart tissues showed extensive confluent necrosis of the myocardium with interfascicular spaces of edema. Degeneration of muscle fibers resulting in disintegration of sarcoplasm and nuclear fragmentation. Confluent lesions were observed in the apex and papillary muscles with focal lesions in other areas of the ventricle. Biochemical studies showed that there was an increase in the levels of lipidperoxide, free fatty acids, glutathione, taurine and decrease in activity of superoxide dismutase and catalase, during experimental myocardial infarction. The effect of administration of Vitamin A, Vitamin C, Vitamin E, and a fatty acid transmembrane transport molecule carnitine on the severity of myocardial infarction was also studied in rats. Judging from the mortality and histopathological studies, it was observed that the order of protection offered to the myocardium from experimental myocardial infarction is as follows — carnitine, Vitamin A, Vitamin C and Vitamin E offered the least protection.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Kerala, Trivandrum, 695 581, Kerala, India

    Venugopal P. Menon, S. Sushma Kumari, A. Jayadeep, J. S. Suresh Kumar, Seleena Mathew & P. A. Kurup

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  1. Venugopal P. Menon
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  2. S. Sushma Kumari
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  3. A. Jayadeep
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  4. J. S. Suresh Kumar
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  5. Seleena Mathew
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  6. P. A. Kurup
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Editor information

Editors and Affiliations

  1. Malaysian Palm Oil Promotion Council, Bangunan Getah Asli 148 Jalan Ampang, 50450, Kuala Lumpur, Malaysia

    A. S. H. Ong

  2. Dept. of Molecular and Cell Biology 251 Life Science Addition, Membrane Bioenergetics Group, Berkeley, California, 94720, USA

    L. Packer

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© 1992 Birkhäuser Verlag, Basel/Switzerland

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Menon, V.P., Kumari, S.S., Jayadeep, A., Kumar, J.S.S., Mathew, S., Kurup, P.A. (1992). Effect of Different Antioxidants in Experimental Myocardial Infarction. In: Ong, A.S.H., Packer, L. (eds) Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7432-8_37

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  • DOI: https://doi.org/10.1007/978-3-0348-7432-8_37

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7434-2

  • Online ISBN: 978-3-0348-7432-8

  • eBook Packages: Springer Book Archive

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