Summary
Erythrocytes infected with Plasmodium berghei and Plasmodium chabaudi had higher lipid peroxidation than normal erythrocytes. The increase in lipid peroxidation in malaria infected cells may be due to reactive oxygen species. Inhibition of endogeneous Superoxide dismutase activity in malaria-infected cells with potassium cyanide increased the rate of lipid peroxidation. Addition of 3-amino-1,2,4-triazole or sodium azide which inhibited endogeneous catalase activity also increase the rate of lipid peroxidation. Furthermore, lipid peroxidation was inhibited by hydroxyl radical scavengers, thiourea and sodium formate and iron chelator, desferrioxamine.
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© 1992 Birkhäuser Verlag, Basel/Switzerland
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Nakornchai, S., Anantavara, S. (1992). Oxygen Free Radicals in Malaria. In: Ong, A.S.H., Packer, L. (eds) Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7432-8_29
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DOI: https://doi.org/10.1007/978-3-0348-7432-8_29
Publisher Name: Birkhäuser Basel
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Online ISBN: 978-3-0348-7432-8
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