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The Roles of Chemical Transformation, Loop Closure, Tunnel Function and Metal Ion Activation in the Tryptophan Synthase Mechanism

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Biochemistry of Vitamin B6 and PQQ

Part of the book series: Advances in Life Sciences ((ALS))

Summary

An overview of the recent results derived from X-ray crystallography, physical biochemical methods, rapid kinetic techniques and site-directed mutagenesis that have shaped current understanding of tryptophan synthase structure-function relationships is presented. An integrated mechanism relating the chemical transformations and metal ion activation to tunnel function and allosteric regulation is proposed.

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References

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of California, Riverside, California, 92521, USA

    Michael F. Dunn, Peter S. Brzovic, Catherine A. Leja, Peng Pan & Eilika U. Woehl

Authors
  1. Michael F. Dunn
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  2. Peter S. Brzovic
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  3. Catherine A. Leja
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  4. Peng Pan
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  5. Eilika U. Woehl
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Editor information

Editors and Affiliations

  1. Dipartimento di Chimica Organica e Biologica, Università di Napoli “Federico II”, Via Mezzocannone 16, I-80134, Napoli, Italy

    G. Marino  & G. Sannia  & 

  2. Dipartimento di Scienze Biochimiche, Università di Roma “La Sapienza”, P.le Aldo Moro 5, I-00185, Roma, Italy

    F. Bossa

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© 1994 Birkhäuser Verlag Basel/Switzerland

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Dunn, M.F., Brzovic, P.S., Leja, C.A., Pan, P., Woehl, E.U. (1994). The Roles of Chemical Transformation, Loop Closure, Tunnel Function and Metal Ion Activation in the Tryptophan Synthase Mechanism. In: Marino, G., Sannia, G., Bossa, F. (eds) Biochemistry of Vitamin B6 and PQQ. Advances in Life Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7393-2_19

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  • DOI: https://doi.org/10.1007/978-3-0348-7393-2_19

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7395-6

  • Online ISBN: 978-3-0348-7393-2

  • eBook Packages: Springer Book Archive

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