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Studies on the mechanism of action of D-amino acid transaminase

  • Conference paper
Biochemistry of Vitamin B6 and PQQ

Part of the book series: Advances in Life Sciences ((ALS))

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Summary

Bacterial D-amino acid transaminase catalyzes the synthesis of D-glutamate and D-alanine for the bacterial cell wall peptidoglycan. The enzyme is likely present in all bacteria but is absent in mammalian cells. The mechanism of action of several enzyme-activated inhibitors (suicide substrates) of bacterial D-amino acid transaminase is reviewed with the objective of defining an inhibitor that might be a useful antimicrobial agent. Site-directed mutagenesis is being used to elucidate the mechanism of action of the enzyme.

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References

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Author information

Authors and Affiliations

  1. The Rockefeller University, New York, 10021, USA

    James M. Manning

Authors
  1. James M. Manning
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Editor information

Editors and Affiliations

  1. Dipartimento di Chimica Organica e Biologica, Università di Napoli “Federico II”, Via Mezzocannone 16, I-80134, Napoli, Italy

    G. Marino  & G. Sannia  & 

  2. Dipartimento di Scienze Biochimiche, Università di Roma “La Sapienza”, P.le Aldo Moro 5, I-00185, Roma, Italy

    F. Bossa

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© 1994 Birkhäuser Verlag Basel/Switzerland

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Manning, J.M. (1994). Studies on the mechanism of action of D-amino acid transaminase. In: Marino, G., Sannia, G., Bossa, F. (eds) Biochemistry of Vitamin B6 and PQQ. Advances in Life Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7393-2_11

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  • DOI: https://doi.org/10.1007/978-3-0348-7393-2_11

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7395-6

  • Online ISBN: 978-3-0348-7393-2

  • eBook Packages: Springer Book Archive

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