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Microbial Virulence and Pathogenesis in Cystic Fibrosis

  • Chapter
Cystic Fibrosis Pulmonary Infections: Lessons from Around the World

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

  • 59 Accesses

Abstract

The abnormal airway conditions in patients with cystic fibrosis (CF) predisposes them to pulmonary infection with a number of bacterial species including Staphylococcus aureus, Haemophilus influenzae, Pseudomonas aeruginosa, Pseudomonas cepacia, Xanthomonas species and various non-tuberculous mycobacteria. Patients with CF may initially become infected with a number of bacterial species including S. aureus [1] and H. influenzae [2], however Pseudomonas aeruginosa is the principal respiratory tract pathogen leading to chronic infection in these patients [3]. Once CF patients are colonized with P. aeruginosa, the organism is rarely eradicated. Another species, Pseudomonas cepacia, is an evolving pathogen in CF infection [4, 5]; its resistance to many antibiotics, enhanced virulence in certain CF patients [6] and the capacity to spread from patient to patient [7] have introduced a new set of problems to CF caregivers.

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  1. Division of Infectious and Immunological Diseases. Department of Paediatrics and the Canadian Bacterial Disease Network, University of British Columbia, Vancouver, Canada

    Dr. Eshwar Mahenthiralingam & Dr. David P. Speert

  2. Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada, V5Z 4H4

    Dr. David P. Speert

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  1. Max von Pettenkofer-Institut, Ludwig-Maximilians-Universität, Pettenkoferstrasse 9a, D-80336, Munich, Germany

    Adolf Bauernfeind

  2. University of California at Irvine, 2801 Atlantic Avenue, 90801, Long Beach, California, USA

    Melvin I. Marks MD (Professor and Vice Chair of Pediatrics, Medical Director/Administrator) (Professor and Vice Chair of Pediatrics, Medical Director/Administrator)

  3. Long Beach Memorial Medical Center, Memorial Miller Children’s Hospital, 2801 Atlantic Avenue, 90801, Long Beach, California, USA

    Melvin I. Marks MD (Professor and Vice Chair of Pediatrics, Medical Director/Administrator) (Professor and Vice Chair of Pediatrics, Medical Director/Administrator)

  4. Department of Pediatrics, Faculty of Medicine, Göteborg University, S-416 85, Göteborg, Sweden

    Birgitta Strandvik MD, PhD (Professor of Pediatrics) (Professor of Pediatrics)

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Mahenthiralingam, E., Speert, D.P. (1996). Microbial Virulence and Pathogenesis in Cystic Fibrosis. In: Bauernfeind, A., Marks, M.I., Strandvik, B. (eds) Cystic Fibrosis Pulmonary Infections: Lessons from Around the World. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7359-8_5

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  • DOI: https://doi.org/10.1007/978-3-0348-7359-8_5

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7361-1

  • Online ISBN: 978-3-0348-7359-8

  • eBook Packages: Springer Book Archive

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