Summary
The present publication reflects our experiences using the Tc-99m labelled intact monoclonal antibody BW 575 for diagnostic use in patients with malignant melanoma. The collective included 45 patients with biopsy-proven malignant melanoma. Our results showed a sensitivity of 56 percent, a specificity of 72 percent and a positive/negative predictive value of 53/75 percent. We conclude that Tc-99m BW 575 is of limited value in the detection of malignant melanoma.
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References
Dudczak R, Kletter K, Bailer H, Kokoschka E, PohlMarkl H. Immunszintigraphie mit einem Technetium-99-mmarkierten monoklonalen Antikörper bei Patienten mit Melanom. Wien Klin Wochenschr 1987; 99: 232–239.
Köhler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specifity. Nature 1975; 256: 495–497.
Buraggi GL, Callegaro L, Mariani G, Turrin A, Cascinelli N, Attili A, Bombardieri E, Terno G, Plassio G, Dovis M et al. Imaging with 131I-labeled monoclonal antibodies to a high-molecular-weight melanoma-associated antigen in patients with melanoma: efficacy of whole immunoglobulin and its F(ab’)2 fragments. Cancer Res 1985; 45: 3378–3387.
Murray JL, Rosenblum MG, Sobol RE, Bartholomew RM, Plager CE, Haynie TP, Jahns MF, Glenn HJ, Lamki L, Benjamin RS et al. Radioimmunoimaging in malignant melanoma with 111In-labeled monoclonal antibody 96.5. Cancer Res 1985; 45: 2376–2381.
Taylor A Jr, Milton W, Eyre HP, Christian P, Wu F, Hagan P, Alazraki N, Datz FL, Unger M. Radioimmunodetection of human melanoma with indium-111labeled monoclonal antibody. J Nucl Med 1988; 29: 329–337.
Eary JF, Schroff RW, Abrams PG, Fritzberg AR, Morgan AC, Kasina S, Reno JM, Srinivasan A, Woodhouse CS, Wilbur DS et al. Successful imaging of malignant melanoma with technetium-99m-labeled monoclonal antibodies. J Nucl Med 1989; 30: 25–32.
Elliott AT, MacKie RM, Murray T, Doherty VR, Adams FG. A comparative study of the relative sensitivity and specificity of radiolabelled monoclonal antibody and computerised tomography in the detection of sites of disease in human malignant melanoma. Br J Cancer 1989; 59: 600–604.
Lamki LM, Zukiwski AA, Shanken LJ, Legha SS, Benjamin RS, Plager CE, Salk DF, Schroff RW, Murray JL. Radioimaging of melanoma using 99mTc-labeled Fab fragment reactive with a high molecular weight melanoma antigen. Cancer Res. 1990; 50 (3 Suppl): 904s–908s.
Buraggi G, Turrin A, Cascinelli N, Attili A, Gasparini M, Callegaro L, Ferrone S, Seregni E, Bombardieri E, Belli F. Radioimmunodetection of melanoma: preliminary results of a prospective study. Int J Biol Markers 1986; 1: 47–54.
Saleh MN, Miller DM, Peterson L, Russell CD, Unger MW, Urist MM, Wheeler RH, LoBuglio AF. Clinical use of a standard kit-preparation of radiolabeled monoclonal antibody 96.5 in the diagnostic imaging of metastatic melanoma. J Clin Oncol 1988; 6: 1059–1065.
Bomanji J, Hungerford JL, Granowska M, Britton KE. Uptake of 99mTc labelled (Fab’)2 fragments of monoclonal antibody 225.28S by a benign ocular naevus. Eur J Nucl Med 1988; 14: 165–166.
Pyrhonen S, Liewendahl K, Muhonen T, Laasonen A, AskoSeljavaara S, Lindroth L, Franssila KO, Virkkunen P, Brownell AL S. Anti-melanoma antibodies bind preferentially to diploid metastases in immunoscintigraphy. Nucl Med Commun 1990; 11: 597–605.
Cerny T, Owens SE, Mackenzie SA, Nuttall PM, Gosh AK, Smith DB, Thatcher N. Immunoscintigraphy with 99mTc labelled F(ab’)2 fragments of an anti melanoma monoclonal antibody (225.28S) in patients with metastatic malignant melanoma. Eur J Nucl Med 1987; 13: 130–133.
Rentsch M, Cerny T, Geiger L, Gerber H, Brunner KW, Rösler H, Nachbur B. Radioimmunszintigraphie mit einem 99mTc-markierten F(ab’)2-Fragment eines monoklonalen Antikörpers (HMW-MAA 225.28S) bei 71 Patienten mit malignem Melanom. Schweiz Med Wschr 1989; 119: 1382–1385.
Siccardi AG, Buraggi GL, Natali PG, Scassellati GA, Viale G, Ferrone S. European multicentre study on melanoma immunoscintigraphy by means of 99mTc-labelled monoclonal antibody fragments. The European Multicentre Study Group. Eur J Nucl Med 1990; 16: 317–323.
Omlor G, Berberich R, Gross G, Alexander C, Feifel G. Erste Erfahrungen mit einem neuen monoklonalen Antikörper in der Diagnostik maligner Melanome. Langenbecks Arch Chir 1991; 376: 359–62.
Halpern SE, Dillman RO, Witztum KF, Shega JF, Hagan PL, Burrows WM, Dillman JB, Clutter ML, Sobol RE, Frincke JM et al. Radioimmunodetection of melanoma utilizing In-111 96.5 monoclonal antibody: a preliminary report. Radiology 1985; 155: 493–499.
Scheidhauer K, Markl A, Leinsinger G, Moser E, Scheiffarth OF, Riedel KG, Schaal TS, Stefani FH, Schumacher U. Immunoscintigraphy in intraocular malignant melanoma. Nucl Med Commun 1988; 9: 669–678.
Lotze MT, Carrasquillo JA, Weinstein JN, Bryant GJ, Perentesis P, Reynolds JC, Matis LA, Eger RR, Keenan AM, Hellstrom I et al. Monoclonal antibody imaging of human melanoma. Radioimmunodetection by subcutaneous or systemic injection. Ann Surg 1986; 204: 223–235.
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© 1995 Birkhäuser Verlag Basel
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Alexander, C. et al. (1995). Radioimmunoscintigraphy of Malignant Melanoma with 99mTc-Labelled Monoclonal Antibody BW 575. In: Bergmann, H., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research. Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7340-6_28
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DOI: https://doi.org/10.1007/978-3-0348-7340-6_28
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