Summary
A wide variety of normal and malignant mammalian cells release extracellular active oxygen species such as superoxide and hydrogen peroxide. These appear to function as life-signals in the balance between proliferation and possible programmed cell death (apoptosis). However, a hazard of such a signalling system is the problem of oxidative damage where such species may be generated in excess and/or in cells that may be deficient in antioxidant protection such as when deprived of serum.
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© 1995 Birkhäuser Verlag Basel/Switzerland
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Burdon, R.H. (1995). Superoxide and hydrogen peroxide as cellularly generated life-signals in the balance between proliferation and cell death. In: Cutler, R.G., Packer, L., Bertram, J., Mori, A. (eds) Oxidative Stress and Aging. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7337-6_4
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DOI: https://doi.org/10.1007/978-3-0348-7337-6_4
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