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Protective role of dietary antioxidants in oxidative stress

  • Conference paper
Oxidative Stress and Aging

Part of the book series: Molecular and Cell Biology Updates ((MCBU))

Summary

Recently, formation of lipofuscin-like substances has been observed in a reaction mixture of rabbit erythrocyte ghost membranes with t-butylhydroperoxide (t-BOOH), which were found to be derived from linoleic acid hydroperoxide and phosphatidyl ethanolamine in the presence of haem, but not from malondialdehyde (MDA) and 4-hydroxynonenal (4-HN). Dietary antioxidants, in particular water-soluble antioxidants were found to inhibit formation of lipofuscin-like substances, although lipid-soluble antioxidants had no effect. However, sesaminol, a novel lipid-soluble antioxidative lignan isolated from sesame oil, was found to prevent effectively both lipid peroxidation induced by carbon tetrachloride (CCl4) and excretion of 8-hydroxy-2’-deoxyguanosine (8-OH-dG) in urine determined by monoclonal antibody method using in vivo system. These effects were also observed in the novel lignan glucosides isolated from sesame seed. Detailed examination has been carried out to find the contribution of phenolic and β-diketone groups for the antioxidative mechanisms.

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References

  • Degan, P., Shigenaga, M., Park, E.-M., Alperrin, P.E. and Ames, B.N. (1991) Isolation of urinary 8-hydroxy-2’deoxyguanosine and 8-hydroxyguanosine and quantification of 8-hydroxy-2’-deoxyguanosine in DNA by polyclonal antibodies. Carcinogenesis 12: 865–871.

    Article  PubMed  CAS  Google Scholar 

  • Ebeler, S.E., Shibamoto, T. and Osawa, T. (1994) Gas and High-performance liquid chromatographic analysis of lipid peroxidation products. In: T. Shibamoto (ed.): Lipid Chromatographic Analysis, Marcel Dekker Inc., New York, pp 223–249.

    Google Scholar 

  • Hariharan, P.V. and Cerutti, P.A. (1974) Excision of Damaged thymine residues from gamma-irradiated poly (dAdT) by crude extracts of E.coli. Proc. Natl. Acad. Sci. USA 71: 3532–3536.

    Article  PubMed  CAS  Google Scholar 

  • Hidargo, F.J. and Zamora, R. (1993) Fluorescent pyrrole products from carbonyl-amine reactions. J. Biol. Chem. 268: 16190–16197.

    Google Scholar 

  • Kaneko, M. and Leadon, S.A. (1986) Production of thymine glycols in DNA by N-hydroxy-2-naphthylamine as detected by a monoclonal antibody. Cancer Res. 56: 71–75.

    Google Scholar 

  • Kasai, H. and Nishimura, S. (1984) Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing reagents. Nucleic Acid Res. 12: 165–173.

    Google Scholar 

  • Katsuzaki, H., Kawakishi, S. and Osawa, T. (1993) Structure of novel antioxidative lignan triglucoside isolated from sesame seed. Heterocycles 36: 933–936.

    Article  CAS  Google Scholar 

  • Katsuzaki, H., Kawakishi, S. and Osawa, T. (1994) Sesaminol glucosides in sesame Seeds. Phytochemistry 35: 773–776.

    Article  PubMed  CAS  Google Scholar 

  • Leadon, S.A. and Hanawalt, P.C. (1983) Monoclonal antibody to DNA containing thymine glycol. Mutation Res. 112: 191–200.

    PubMed  CAS  Google Scholar 

  • Mcbrien, D.C.H. and Slater, T.F. (1982) Free Radicals, Lipid Peroxidation and Cancer, Academic Press, New York.

    Google Scholar 

  • Okamoto, S. and Ochi, H. (1992) Monoclonal antibody to 8-hydroxy-2’-deoxyguanosine and hybridomas producing the monoclonal antibody. Chemical Abst. 129859a.

    Google Scholar 

  • Osawa, T. and Namiki, M. (1981) A novel antioxidants isolated from leaf wax of Eucalyptus leaves. Agric. Biol. Chem. 45: 735–939.

    Article  CAS  Google Scholar 

  • Osawa, T. and Namiki, M. (1985) Natural antioxidants isolated from Eucalyptus leaf waxes. J. Agric. Food Chem. 33: 777–780.

    Article  CAS  Google Scholar 

  • Osawa, T., Ide, A., Su, J.-D. and Namiki, M. (1987) Inhibition of lipid peroxidation by ellagic acid. J. Agric. Food Chem. 35: 808–812.

    Article  CAS  Google Scholar 

  • Osawa, T., Namiki, M. and Kawakishi, S. (1989) Role of Dietary Antioxidants in Protection against Oxidative Damage. In: Y. Kuroda, D.M. Shankel and M.D.Waters (eds): Antimutagenesis and Anticarcinogenesis Mechanisms II. Plenum Press, New York, pp 139–153.

    Google Scholar 

  • Osawa, T., Kumon, H., Fukuda, Y., Namiki, M. and Kawakishi, S. (1990) In: M.W. Pariza, H.-U. Aeschbacher, J.S. Felton and S. Sato (eds): Mutagens and Carcinogens in the Diet. Wiley-Liss Inc., New York, pp 223–238.

    Google Scholar 

  • Osawa, T., Kumazawa, S. and Kawakishi, S. (1991) Prunusols A and B, Novel Antioxidative Tocopherol Derivatives Isolated from the Leaf Wax of Prunus grayana Maxim. Agric. Biol. Chem. 55: 1727–1731.

    Article  CAS  Google Scholar 

  • Osawa, T. (1992a) Phenolic Antioxidants in Dietary Plants as Antimutagens. In: C.-T. Ho, C.Y. Lee and M.-T. Huang (eds): Phenolic Compounds in Food and Health. Washington, D.C.: ACS, pp 135–149.

    Chapter  Google Scholar 

  • Osawa, T., Katsuzaki, H., Hagiwara, Y., Hagiwara, H. and Shibamoto, T. (1992b) A Novel Antioxidant Isolated from Young Green Barley Leaves. J. Agric. Food Chem. 40: 1135–1138.

    Article  CAS  Google Scholar 

  • Osawa, T., Morioka, Y. and Kawakishi, S. (1993) High-pressure liquid chromatography determination of malondialdehide in lipid peroxidation systems via a pyrimidine derivative. Inform 4 (4): 512.

    Google Scholar 

  • Park, E.-M., Shigenaga, M.K., Degan, P., Korn, T.S., Kitzler, J.W., Wehr, C.M., Kolachana, P. and Ames, B.N. (1992) Isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column. Proc. Natl. Acad. Sci. USA 89: 3375–3379.

    Article  PubMed  CAS  Google Scholar 

  • Ramarathnam, N., Osawa, T., Namiki, M. and Kawakishi, S. (1989) Chemical studies on novel rrice hull antioxidants: 2. identification of isovetoxin, A C-glycosylflavonoid. J. Agric. Food Chem. 37: 316–319.

    Article  CAS  Google Scholar 

  • Shima, A. (1988) Effect of Food Components on Cellular Aging. In: M. Fujimaki (ed.): Food Functionalities. Tokyo, Gakkai Press Center, pp 227–231.

    Google Scholar 

  • Su, J.-D, Osawa, T, Kawakishi, S. and Namiki, M. (1988) Tannin antioxidants from Osbeckia chinensis. Phytochemistry 27: 1315–1319.

    Article  CAS  Google Scholar 

  • Tusda, T., Osawa, T., Nakayama, T., Kawakishi, S. and Oshima, K. (1993) Antioxidant activity of pea bean (Phaseolus vulgaris L.) extracts. J. Am. Oil. Chem. Soc. 70: 909–913.

    Article  Google Scholar 

  • Witz, G. (1989) Biological interaction of α,β-unsaturated aldehyde. Free Radical Biol. Med. 7: 333–349.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Applied Biological Sciences, Nagoya University, Chikusa, Nagoya, 464-01, Japan

    T. Osawa, A. Yoshida & S. Kawakishi

  2. Sugiyama Jogakuen University, Chikusa 464, Nagoya, Japan

    K. Yamashita

  3. Japan Institute for the Control of Aging, Shizuoka, 437-01, Japan

    H. Ochi

Authors
  1. T. Osawa
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  2. A. Yoshida
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  3. S. Kawakishi
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  4. K. Yamashita
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  5. H. Ochi
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Editor information

Editors and Affiliations

  1. Gerontology Research Center, National Institute on Aging, NIH, 21224, Baltimore, MD, USA

    R. G. Cutler

  2. Dept. Molecular and Cell Biology, 251 Life Science Addition, Membrane Bioenergetics Group, 94720, Berkeley, CA, USA

    L. Packer

  3. Cancer Research Center of Hawaii, Molecular Oncology, University of Hawaii at Manoa, 1236 Lauhala Street, 96813, Honolulu, HI, USA

    J. Bertram

  4. Dept. of Neuroscience, Institute of Cellular and Molecular Medicine, Okayama University, 2-5-1 Shikatacho, Okayama 700, Japan

    A. Mori

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© 1995 Birkhäuser Verlag Basel/Switzerland

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Osawa, T., Yoshida, A., Kawakishi, S., Yamashita, K., Ochi, H. (1995). Protective role of dietary antioxidants in oxidative stress. In: Cutler, R.G., Packer, L., Bertram, J., Mori, A. (eds) Oxidative Stress and Aging. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7337-6_34

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  • DOI: https://doi.org/10.1007/978-3-0348-7337-6_34

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7339-0

  • Online ISBN: 978-3-0348-7337-6

  • eBook Packages: Springer Book Archive

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