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Oxidative stress and brain damage as the pathogenesis of epilepsy

  • Conference paper
Oxidative Stress and Aging

Part of the book series: Molecular and Cell Biology Updates ((MCBU))

Abstract

The brain and nervous system are especially prone to free radical damage since the membrane lipids are very rich in polyunsaturated fatty acid side chains, and areas of the human brain are rich in iron which plays an essential role in generating reactive oxygen species (Halliwell, 1989). In addition, the brain reportedly utilizes about one-fifth of the oxygen taken in each day (Ames et al., 1981). Therefore, neurons are especially vulnerable to free radical attack.

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Author information

Authors and Affiliations

  1. Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700, Japan

    A. Mori, I. Yokoi, J. Liu & K. Mizukawa

Authors
  1. A. Mori
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  2. I. Yokoi
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  3. J. Liu
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  4. K. Mizukawa
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Editor information

Editors and Affiliations

  1. Gerontology Research Center, National Institute on Aging, NIH, 21224, Baltimore, MD, USA

    R. G. Cutler

  2. Dept. Molecular and Cell Biology, 251 Life Science Addition, Membrane Bioenergetics Group, 94720, Berkeley, CA, USA

    L. Packer

  3. Cancer Research Center of Hawaii, Molecular Oncology, University of Hawaii at Manoa, 1236 Lauhala Street, 96813, Honolulu, HI, USA

    J. Bertram

  4. Dept. of Neuroscience, Institute of Cellular and Molecular Medicine, Okayama University, 2-5-1 Shikatacho, Okayama 700, Japan

    A. Mori

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© 1995 Birkhäuser Verlag Basel/Switzerland

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Mori, A., Yokoi, I., Liu, J., Mizukawa, K. (1995). Oxidative stress and brain damage as the pathogenesis of epilepsy. In: Cutler, R.G., Packer, L., Bertram, J., Mori, A. (eds) Oxidative Stress and Aging. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7337-6_29

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  • DOI: https://doi.org/10.1007/978-3-0348-7337-6_29

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7339-0

  • Online ISBN: 978-3-0348-7337-6

  • eBook Packages: Springer Book Archive

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