Skip to main content
SpringerLink
Log in

Parkinson’s disease, dopamine and free radicals

  • Conference paper
Oxidative Stress and Aging

Part of the book series: Molecular and Cell Biology Updates ((MCBU))

Abstract

Free radicals have been shown to play an important role in neuronal damage due to trauma, illness or neurotoxins (Demopoulos et al., 1982; Halliwell and Gutteridge, 1985; Traysteman et al., 1991). Parkinson’s disease (PD) is a slowly progressive neurodegenerative disease that can be caused by several factors (Langston et al., 1983; Naoi et al., 1993; Mizuno et al., 1989) and recent studies suggest that free radicals may play a key role in the progression of PD (Adams and Odunze, 1991; Chacon et al., 1987; Cohen, 1986; Sinha et al., 1986).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams, J.D., Jr. and Odunze, I.N. (1991) Oxygen free radicals and Parkinson’s disease. Free Radical Biol. Med. 10: 161–169.

    Article  CAS  Google Scholar 

  • Ambani, L.M., Van Woert, M.H. and Murphy, S. (1975) Brain peroxidase and catalase in Parkinson’s disease. Arch. Neural. 32: 114–118.

    Article  CAS  Google Scholar 

  • Cedarbaum, J.M., Gandy, S.E. and McDowell, F.H. (1991) “Early” initiation of levodopa treatment does not promote the development of motor fluctuations, dyskinesias, or dementia in Parkinson’s disease. Neurology 41: 622–629.

    PubMed  CAS  Google Scholar 

  • Chacon, J.N., Chedekel, M.R., Land, E.J. and Truscott, T.G. (1987) Chemically induced Parkinson’s disease: intermediates in the oxidation of 1-methyl-4-phenylpyridinium ion. Biochem. Biophys. Res. Commun. 144: 957–964.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, G. (1985) Oxidative stress in the nervous system. In: H. Sies (ed.): Oxidative Stress, Academic Press, New York, pp 383–402.

    Google Scholar 

  • Cohen, G. (1986) Monoamine oxidase, hydrogen peroxide, and Parkinson’s disease. Adv. Neurol. 45: 119–125.

    Google Scholar 

  • Demopoulos, H.B., Flamm, E., Seligman, M. and Pietronigro, D.D. (1982) Oxygen free radicals in central nervous system: ischemia and trauma. In: A.P. Autor (ed.): Pathology of Oxygen, Academic Press, New York, pp 127–155.

    Google Scholar 

  • Feltem, D.L., Felten, S.Y., Fuller, R.W., Romano, T.D., Smalstig, E.B., Wong, D.T. and Clemens, J.A. (1992) Chronic dietary pergolide preserves nigrostriatal neuronal integrity in aged-Fischer-344 rats. Neurobiol. Aging 13: 339–351.

    Article  Google Scholar 

  • Friedman, A. and Sienkiewicz, F. (1991) Psychotic complications of long-term levodopa treatment of Parkinson’s disease. Acta Neuropathol. Scand. 84: 111–113.

    Article  CAS  Google Scholar 

  • Halliwell, B. (1992) Reactive oxygen species and the central nervous system. J. Neurochem. 59: 1609–1623.

    Article  PubMed  CAS  Google Scholar 

  • Halliwell, B. and Gutteridge, J.M.C. (1985) Oxygen radicals and the nervous system. Trends Neurosci. 8: 22–26.

    Article  Google Scholar 

  • Hoehn, M.M.M. (1986) Parkinson’s disease: progression and mortality. Adv. Neurol. 45: 457–461.

    Google Scholar 

  • Kish, S.J., Morito, C. and Hornykiewicz, O. (1985) Glutathione peroxidase activity in Parkinson’s disease. Neurosci. Lett. 58: 343–346.

    Article  PubMed  CAS  Google Scholar 

  • Langston, J.W., Ballard, P. and Tetrud, J.W. (1983) Chronic parkinsonism in humans due to meperidine synthesis. Science 219: 979–980.

    Article  PubMed  CAS  Google Scholar 

  • Marttila, R.J., Lorentz, H. and Rinne, U.K. (1988) Oxygen toxicity protecting enzymes in Parkinson’s disease. J. Neurol. Sci. 86: 321–331.

    Article  PubMed  CAS  Google Scholar 

  • Mizuno, Y., Ohta, S., Tanaka, M., Takayama, S., Suzuki, K., Sato, T., Oya, H., Ozawa, T. and Kagawa, Y. (1989) Deficiencies in complex I subunits of the respiratory chain in Parkinson’s disease. Biochem. Biophys. Res. Commun. 163: 1450–1455.

    Article  PubMed  CAS  Google Scholar 

  • Nakanishi, T., Iwata, M., Goto, I., Kanazawa, I., Kowa, H., Mannen, T., Mizuno, Y., Nishitani, H., Ogawa, N., Takahashi, A., Tashiro, K., Tohogi, H. and Yanagisawa, N. (1992) Nation-wide collaborative study on the longterm effects of bromocriptine in the treatment of parkinsonian patients. Eur. Neurol. 32 (suppl. 1): 9–22.

    Article  PubMed  Google Scholar 

  • Naoi, M., Dostert, P., Yoshida, M. and Nagatu, T. (1993) N-Methylated tetrahydroisoquinolines as dopaminergic neurotoxins. Adv. Neurol. 60: 212–217.

    PubMed  CAS  Google Scholar 

  • Ogawa, N. (1994) Levodopa and dopamine agonists in the treatment of Parkinson’s disease: advantages and disadvantages. Eur. Neurol. 34 (suppl. 3): 20–28.

    Article  PubMed  Google Scholar 

  • Ogawa, N., Edamatsu, R., Mizukawa, K., Asanuma, M., Kohno, M. and Mori, A. (1993) Degeneration of dopaminergic neurons and free radicals: possible participation of levodopa. Adv. Neurol. 60: 242–250.

    PubMed  CAS  Google Scholar 

  • Parkinson’s Study Group (1989) Effects of deprenyl on progression of disability in early Parkinson’s disease. New Engl. J. Med. 321: 1364–1371.

    Google Scholar 

  • Rinne, U.K. (1981) Treatment of Parkinson’s disease: problems with a progressing disease. J. Neural. Transm. 51: 161–174.

    Article  PubMed  CAS  Google Scholar 

  • Rinne, U.K. (1987) Early combination of bromocriptine and levodopa in the treatment of Parkinson’s disease: a 5-year follow-up. Neurology 37: 826–828.

    PubMed  CAS  Google Scholar 

  • Rinne, U.K., Sonninen, V. and Siirtola, T. (1976) Long-term treatment of parkinsonism with L-DOPA and decarboxylase inhibitor: A clinical and biochemical approach. In: W. Birkmayer and O. Hornykiewicz (eds): Advances in Parkinsonism, Editiones Roche, Basle, pp 555–565.

    Google Scholar 

  • Robertson, G.S. and Robertson, H.A. (1986) Synergic effects of D-1 and D-2 dopamine agonists on turning behaviour in rats. Brain Res. 284: 387–390.

    Article  Google Scholar 

  • Scigliano, G., Musicco, M., Soliveri, P., Piccolo, I., Girotti, F., Giovannini, P. and Caraceni, T. (1990) Mortality associated with early and late levodopa therapy initiation in Parkinson’s disease. Neurology 40: 265–269.

    PubMed  CAS  Google Scholar 

  • Sinha, B.K., Singh, Y. and Krishna, G. (1986) Formation of superoxide and hydroxyl radicals from 1-methyl-4phenylpyridinium ion (MPP+): reductive activation by NADPH cytochrome P450 reductase. Biochem. Biophys. Res. Commun. 135: 583–588.

    Article  PubMed  CAS  Google Scholar 

  • Starr, B.S. and Starr, M.S. (1987) Behavioural interactions involving D1 and D2 dopamine receptors in on-habituated mice. Neuropharmacology 26: 613–619.

    Article  PubMed  CAS  Google Scholar 

  • Tanaka, M., Sotomatsu, A., Kanai, H. and Hirai, S. (1991) Dopa and dopamine cause cultured neuronal death in the presence of iron. J. Neurol. Sci. 101: 198–203.

    Article  PubMed  CAS  Google Scholar 

  • Traysteman, R.J., Kirsch, J.R., Koehler, R.C. (1991) Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J. Appl. Physiol. 71: 1185–1195.

    Google Scholar 

  • Yurek, D.M., Steece-Collier, K., Collier, T.J. and Sladek, J.R., Jr. (1991) Chronic levodopa impairs the recovery of dopamine agonist-induced rotational behavior following neural grafting. Exp. Brain Res. 86: 97–107.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700, Japan

    N. Ogawa & A. Mori

Authors
  1. N. Ogawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Mori
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Gerontology Research Center, National Institute on Aging, NIH, 21224, Baltimore, MD, USA

    R. G. Cutler

  2. Dept. Molecular and Cell Biology, 251 Life Science Addition, Membrane Bioenergetics Group, 94720, Berkeley, CA, USA

    L. Packer

  3. Cancer Research Center of Hawaii, Molecular Oncology, University of Hawaii at Manoa, 1236 Lauhala Street, 96813, Honolulu, HI, USA

    J. Bertram

  4. Dept. of Neuroscience, Institute of Cellular and Molecular Medicine, Okayama University, 2-5-1 Shikatacho, Okayama 700, Japan

    A. Mori

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Birkhäuser Verlag Basel/Switzerland

About this paper

Cite this paper

Ogawa, N., Mori, A. (1995). Parkinson’s disease, dopamine and free radicals. In: Cutler, R.G., Packer, L., Bertram, J., Mori, A. (eds) Oxidative Stress and Aging. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7337-6_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-7337-6_28

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7339-0

  • Online ISBN: 978-3-0348-7337-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation