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Free radicals in the pathogenesis of diabetes and its complications

  • Conference paper
Oxidative Stress and Aging

Part of the book series: Molecular and Cell Biology Updates ((MCBU))

Summary

The successful defense against hostile and irritating influences is a remarkable ability of living structures. If they fail, they are condemned to death; if they are only partially successful, the result will be disease or aging. Free radicals seem to be the common effectors at the end of many chains of reaction triggered by exogenous and endogenous noxae. Thus coping with the production and defense of free radicals will be a major determinant of integrity or destruction of living structures. Diabetes mellitus is an apparent example of a disorder which is caused by free radicals and which itself results in their generation, thus producing secondary diseases. It is the aim of this review to describe our present knowledge of the role of free radicals in the pathogenesis of type 1 diabetes and to present some views of their role in the development of diabetic complications.

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Author information

Authors and Affiliations

  1. Diabetes-Forschungsinstitut, Heinrich-Heine-Universität Düsseldorf, Auf’m Hennekamp 65, D-40225, Düsseldorf, Germany

    F. A. Gries, H. Kolb & T. Koschinsky

Authors
  1. F. A. Gries
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  2. H. Kolb
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  3. T. Koschinsky
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Editor information

Editors and Affiliations

  1. Gerontology Research Center, National Institute on Aging, NIH, 21224, Baltimore, MD, USA

    R. G. Cutler

  2. Dept. Molecular and Cell Biology, 251 Life Science Addition, Membrane Bioenergetics Group, 94720, Berkeley, CA, USA

    L. Packer

  3. Cancer Research Center of Hawaii, Molecular Oncology, University of Hawaii at Manoa, 1236 Lauhala Street, 96813, Honolulu, HI, USA

    J. Bertram

  4. Dept. of Neuroscience, Institute of Cellular and Molecular Medicine, Okayama University, 2-5-1 Shikatacho, Okayama 700, Japan

    A. Mori

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© 1995 Birkhäuser Verlag Basel/Switzerland

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Gries, F.A., Kolb, H., Koschinsky, T. (1995). Free radicals in the pathogenesis of diabetes and its complications. In: Cutler, R.G., Packer, L., Bertram, J., Mori, A. (eds) Oxidative Stress and Aging. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7337-6_20

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  • DOI: https://doi.org/10.1007/978-3-0348-7337-6_20

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7339-0

  • Online ISBN: 978-3-0348-7337-6

  • eBook Packages: Springer Book Archive

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