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Control of alcohol metabolism

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Toward a Molecular Basis of Alcohol Use and Abuse

Part of the book series: Experientia ((EXS,volume 71))

Summary

The rate of alcohol metabolism is determined by the kinetic characteristics and concentrations of the alcohol and aldehyde dehydrogenases and by the rate of restoration of the redox state of the cell. Several potent competitive and uncompetitive inhibitors of the alcohol dehydrogenases can decrease the rate of alcohol metabolism; they may be useful for preventing the potentially deleterious effects of ethanol metabolism. Alcohol dehydrogenases have very broad specificity and can readily reduce a variety of carbonyl compounds by exchange reactions while ethanol is metabolized. Agents that increase the rate of metabolism need to be developed.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, The University of Iowa, Iowa City, Iowa, 52242, USA

    Bryce V. Plapp

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  1. Bryce V. Plapp
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, Karolinska Institutet, Huddinge University Hospital, S-141 86, Huddinge, Sweden

    B. Jansson

  2. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77, Stockholm, Sweden

    H. Jörnvall

  3. Department of Clinical Neuroscience, Karolinska Institutet, S-171 76, Stockholm, Sweden

    U. Rydberg  & L. Terenius  & 

  4. Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Seeley G. Mudd Building, 250 Longwood Avenue, 02115, Boston, MA, USA

    B. L. Vallee

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© 1994 Birkhäuser Verlag Basel/Switzerland

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Plapp, B.V. (1994). Control of alcohol metabolism. In: Jansson, B., Jörnvall, H., Rydberg, U., Terenius, L., Vallee, B.L. (eds) Toward a Molecular Basis of Alcohol Use and Abuse. Experientia, vol 71. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7330-7_31

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  • DOI: https://doi.org/10.1007/978-3-0348-7330-7_31

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7332-1

  • Online ISBN: 978-3-0348-7330-7

  • eBook Packages: Springer Book Archive

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