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Adaptation of signal transduction in brain

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Toward a Molecular Basis of Alcohol Use and Abuse

Part of the book series: Experientia ((EXS,volume 71))

Summary

Cell culture models were used to study the effects of long-term ethanol exposure on neuronal cells. Effects on phopholipase C and phospholipase D mediated signal transduction were investigated by assaying receptor-binding, G protein function, activities of lipases, formation of second messengers and c-fos mRNA. The signal transduction cascades displayed abnormal activities from 2 to 7 days of exposure which differed from the acute effects. Phosphatidylethanol formed by phospholipase D is an abnormal lipid that may harmfully affect nerve cell function.

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Author information

Authors and Affiliations

  1. Dept. of Psychiatry and Neurochemistry, Lund University, POB 638, S-220 09, Lund, Sweden

    C. Alling, L. Gustavsson, C. Larsson, C. Lundqvist, D. Rodriguez & P. Simonsson

  2. Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Salamanca, E-37007, Salamanca, Spain

    D. Rodriguez

Authors
  1. C. Alling
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  2. L. Gustavsson
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  3. C. Larsson
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  4. C. Lundqvist
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  5. D. Rodriguez
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  6. P. Simonsson
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, Karolinska Institutet, Huddinge University Hospital, S-141 86, Huddinge, Sweden

    B. Jansson

  2. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77, Stockholm, Sweden

    H. Jörnvall

  3. Department of Clinical Neuroscience, Karolinska Institutet, S-171 76, Stockholm, Sweden

    U. Rydberg  & L. Terenius  & 

  4. Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Seeley G. Mudd Building, 250 Longwood Avenue, 02115, Boston, MA, USA

    B. L. Vallee

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© 1994 Birkhäuser Verlag Basel/Switzerland

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Alling, C., Gustavsson, L., Larsson, C., Lundqvist, C., Rodriguez, D., Simonsson, P. (1994). Adaptation of signal transduction in brain. In: Jansson, B., Jörnvall, H., Rydberg, U., Terenius, L., Vallee, B.L. (eds) Toward a Molecular Basis of Alcohol Use and Abuse. Experientia, vol 71. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7330-7_3

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  • DOI: https://doi.org/10.1007/978-3-0348-7330-7_3

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7332-1

  • Online ISBN: 978-3-0348-7330-7

  • eBook Packages: Springer Book Archive

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