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Drug metabolism and signal transduction: Possible role of Ah receptor and arachidonic acid cascade in protection from ethanol toxicity

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Toward a Molecular Basis of Alcohol Use and Abuse

Part of the book series: Experientia ((EXS,volume 71))

Summary

It has become increasingly clear that the so-called ‘drug-metabolizing enzymes,’ and the receptors controlling them, play a key role in regulating the steady-state levels of ligands important in the transcription of genes involved in cell division, differentiation, apoptosis, homeostasis, and neuroendocrine functions. In this Chapter is presented an example of the possible role of the high-affinity Ah receptor in protection against ethanol-induced inflammation by way of the arachidonic acid cascade. Ethanol consumption is associated with cancer, inflammation, birth defects, and other toxic effects. Ethanol-induced toxicity appears to be mediated by many of the same oxidative stress signal transduction pathways used by other tumor promoters, teratogens, mitogens and comitogens.

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Author information

Authors and Affiliations

  1. Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio, 45267-0056, USA

    Daniel W. Nebert

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  1. Daniel W. Nebert
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, Karolinska Institutet, Huddinge University Hospital, S-141 86, Huddinge, Sweden

    B. Jansson

  2. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77, Stockholm, Sweden

    H. Jörnvall

  3. Department of Clinical Neuroscience, Karolinska Institutet, S-171 76, Stockholm, Sweden

    U. Rydberg  & L. Terenius  & 

  4. Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Seeley G. Mudd Building, 250 Longwood Avenue, 02115, Boston, MA, USA

    B. L. Vallee

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© 1994 Birkhäuser Verlag Basel/Switzerland

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Nebert, D.W. (1994). Drug metabolism and signal transduction: Possible role of Ah receptor and arachidonic acid cascade in protection from ethanol toxicity. In: Jansson, B., Jörnvall, H., Rydberg, U., Terenius, L., Vallee, B.L. (eds) Toward a Molecular Basis of Alcohol Use and Abuse. Experientia, vol 71. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7330-7_23

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  • DOI: https://doi.org/10.1007/978-3-0348-7330-7_23

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7332-1

  • Online ISBN: 978-3-0348-7330-7

  • eBook Packages: Springer Book Archive

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