Summary
Forensic serology deals with cases of disputed paternity and criminal stains. The spectacular improvement using DNA-profiling is best demonstrated with cases of criminal stains where with the same ease as a suspect can be identified, an innocent person can be excluded. In cases with band-shifting, a statistical definition of a match applying Bayes theorem as a decision making tool seems mandatory since matching or non-matching cannot be treated as a binary event. Good postmortem DNA stability is found in brain cortex, lymph nodes and psoas muscle. DNA fingerprinting is also a perfect tool to investigate disputed identity of blood alcohol samples. In paternity cases, we recommend both multi locus and single locus probes in kinship cases, e.g. in mother-child-putative father cases as well as father-daughter and brother-sister incest cases, grandparent cases and two-men cases. For the biostatistical evaluation of SLP patterns the formal genetics for a system of multiple allelism is used and for multi locus probes the model of multiple diallelism is applicable.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bär, W., Kratzer, A., Mächler, M., and Schmid, W. (1988) Postmortem Stability of DNA. Forensic. Sci. Intern. 39: 59–70.
Bär, W., and Kratzer, A. (1989) Abklärung strittiger Identität von Blutalkoholproben mit DNA-Fingerprinting. Z. Rechtsmed. 102: 263 –270.
Bradley, H. C. (1938) Autolysis and atrophy. Physiol. Rev. 18: 173.
Burke, T., and Bruford, M. W. (1987) DNA fingerprinting in birds. Nature 327: 149–152.
Essen-Willer, E. (1938) Die Beweiskraft der Aehnlichkeit im Vaterschaftsnachweis; theoretische Grundlagen. Mitt. Anthrop. Ges. ( Wien ) 68: 9–53.
Gill, P. (1987) A new method for sex determination of the donor of forensic samples using a recombinant DNA probe. Electrophoresis 8: 35–38.
Gill, P., Jeffreys, A. J., and Werret, D. J. (1985) Forensic application of DNA “fingerprints”. Nature 318: 577–579.
Gill, P., Werrett, D. J., and Evett, I. W. (1990) Problems associated with the determination of band match probabilities. Advances Forens Haemogenetics, vol. 3., Polesky, H. F. and Mayr, W. R. ( eds. ), Springer Verlag Berlin Heidelberg, p. 63–67.
Goelz, S. E., Hamilton, S. R., and Vogelstein, B. (1985) Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. . 130: 118–126.
Gössner, W. (1955) Untersuchungen über das Verhalten der Phosphatasen und Esterasen während der Autolyse. Virchows Arch. 327: 304.
Hughes, Margaret A., and Jones, D. S. (1986) Body in the bog but no DNA. Nature 323: 208.
Hummel, K., Fukshansky, N., Bär, W., and Zang, K. (1990) Biostatistical approaches using minisatellite DNA patterns in paternity cases (mother-child-putative father trios). Advances Forensic Haemogenetics, vol. 3., Polesky, H. F., and Mayr, W. R. ( eds. ), Springer Verlag Berlin Heidelberg, p. 17–22.
Ihm, P., and Hummel, K. (1975) Ein Verfahren zur Ermittlung der Vaterschafstwahrscheinlichkeit aus Blutgruppenbefunden unter beliebiger Einbeziehung von Verwandten. Z. Immun. Forsch. 149: 405–416.
Jeffreys, A. J. (1984) Raising the dead and buried. Nature 312: 198.
Jeffreys, A. J., Wilson, V., and Thein, S. L. (1985) Hypervariable “minisatellite” regions in human DNA. Nature 314: 67–73.
Jeffreys, A. J., Wilson, V., Thein, S. L., Weatherall, D. J., and Ponder, B. A. J. (1986) DNA “Fingerprints” and segregation analysis of multiple markers in human pedigrees. Am. J. Hum. Genet. 39: 11–24.
Lander, E. S., (1989) DNA Fingerprinting on trial. Nature 339: 501–505.
Lansman, R. A., Shade, R. O., Shapira, J. F., and Avise, J. C. (1981) The use of restriction endonucleases to measure mitochondrial DNA sequence relatedness in natural populations. J. Mol. Evol. 17: 214–226.
Mackie, F. P. (1929) The microscopical changes occuring in organs after death. Ind. J. Med. Res. 16: 827.
Madisen, L., Hoar, D. I., Holroyd, C. D., Crisp, M., and Hodes, M. E. (1987) DNA banking: The effects of storage of blood and isolated DNA on the integrity of DNA. Am. J. Med. Genet. 27: 379–390.
Pääbo, S. (1985) Molecular cloning of ancient Egyptian mummy DNA. Nature 314: 644–645.
Wood, T. L., Frantz, G. D., Menkes, J. H., and Tobin, A. J. (1986) Regional distribution of messenger RNAs in postmortem human brain. J. Neurosci. Res. 16: 311–324.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Birkhäuser Verlag Basel/Switzerland
About this chapter
Cite this chapter
Bär, W., Hummel, K. (1991). DNA Fingerprinting: Its Application in Forensic Case Work. In: Burke, T., Dolf, G., Jeffreys, A.J., Wolff, R. (eds) DNA Fingerprinting: Approaches and Applications. Experientia Supplementum, vol 58. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7312-3_25
Download citation
DOI: https://doi.org/10.1007/978-3-0348-7312-3_25
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-0348-7314-7
Online ISBN: 978-3-0348-7312-3
eBook Packages: Springer Book Archive