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Molecular analysis of Drosophila glutamate receptors

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Comparative Molecular Neurobiology

Part of the book series: EXS ((EXS,volume 63))

Summary

Insects and other invertebrates use L-glutamate as a neurotransmitter in the central nervous system and at the neuromuscular junction. In contrast to the well-studied effects of L-glutamate on invertebrate muscle cells, relatively little is known about the physiological role of glutamate receptors (GluRs) in the invertebrate central nervous system. We have applied a molecular cloning approach to elucidate the molecular structure of neuronal and muscle-specific Drosophila glutamate receptor subunits (DGluRs). Several domains conserved between rat GluR subunits and DGluRs indicate regions of high functional significance. Drosophila genetics may now be used as a valuable experimental tool to gain further insight into the role of DGluRs in development, synaptic plasticity and control of gene expression.

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Authors and Affiliations

  1. Abteilung Neurochemie, Max-Planck-Institut für Hirnforschung, Deutschordenstraße 46, D-W6000, Frankfurt 71, Federal Republic of Germany

    Christoph M. Schuster, Andreas Ultsch, Bertram Schmitt & Heinrich Betz

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  1. Christoph M. Schuster
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  2. Andreas Ultsch
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  3. Bertram Schmitt
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  4. Heinrich Betz
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Editors and Affiliations

  1. Equipe de Neurobiologie, C.N.R.S.-Université de Rennes I, Bât. 13-Complexe Univ. de Beaulieu, F-35042, Rennes Cedex, France

    Yves Pichon

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© 1993 Birkhäuser Verlag Basel/Switzerland

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Schuster, C.M., Ultsch, A., Schmitt, B., Betz, H. (1993). Molecular analysis of Drosophila glutamate receptors. In: Pichon, Y. (eds) Comparative Molecular Neurobiology. EXS, vol 63. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7265-2_11

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  • DOI: https://doi.org/10.1007/978-3-0348-7265-2_11

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7267-6

  • Online ISBN: 978-3-0348-7265-2

  • eBook Packages: Springer Book Archive

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