Molecular biology of excitatory amino acid receptors: Subtypes and subunits
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Glutamate receptors coupled to ion channels have been named according to their selective agonist: N-methyl-D-Aspartate (NMDA), kainate, quisqualate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA). The pharmacology of the NMDA receptor is clearly different from that of the kainate, quisqualate and AMPA receptors, thus differentiating two types: NMDA and non-NMDA receptors. Molecular cloning and expression of non-NMDA receptor subunits have now established that the different neuronal responses to kainate, quisqualate and AMPA are mediated by at least two subtypes of ligand-gated channels: one responding to the three ligands, the other responding to kainate and quisqualate but not to AMPA.
KeywordsGlutamate Receptor Transmembrane Domain AMPA Receptor Receptor Subunit Kainate Receptor
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