Summary
Glutamate receptors coupled to ion channels have been named according to their selective agonist: N-methyl-D-Aspartate (NMDA), kainate, quisqualate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA). The pharmacology of the NMDA receptor is clearly different from that of the kainate, quisqualate and AMPA receptors, thus differentiating two types: NMDA and non-NMDA receptors. Molecular cloning and expression of non-NMDA receptor subunits have now established that the different neuronal responses to kainate, quisqualate and AMPA are mediated by at least two subtypes of ligand-gated channels: one responding to the three ligands, the other responding to kainate and quisqualate but not to AMPA.
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Abbreviations
- AMPA:
-
α amino-3-hydroxy-5-methyl-4-isoxazolepropionate
- CNQX:
-
6-cyano-7-nitro-quinoxaline-2,3-dione
- DNQX:
-
6,7-dinitro-quinoxaline-2,3-dione
- NMDA:
-
N-methyl-D-aspartate.
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© 1993 Birkhäuser Verlag Basel/Switzerland
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Bochet, P., Rossier, J. (1993). Molecular biology of excitatory amino acid receptors: Subtypes and subunits. In: Pichon, Y. (eds) Comparative Molecular Neurobiology. EXS, vol 63. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7265-2_10
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DOI: https://doi.org/10.1007/978-3-0348-7265-2_10
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