Summary
Serotonin (5-HT) stimulated the uptake of 3H-thymidine into cultured vascular smooth cells from the rat aorta. Thrombin also stimulated mitogenesis, and potentiated the effect of 5-HT. However, the percent increase in 5-HT-induced mitogenesis was unchanged after the addition of thrombin. The mitogenic effect of 5-HT was not inhibited by the dihydropyridine calcium channel blocker, nifedipine (1 μM), but the action of thrombin was. These results suggest that 5-HT and thrombin act through different, but interacting, signal transduction mechanisms to produce mitogenesis.
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© 1991 Birkhäuser Verlag Basel/Switzerland
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Kent, T.A., Jazayeri, A., Simard, J.M. (1991). Serotonin as a Vascular Smooth Muscle Cell Mitogen. In: Fozard, J.R., Saxena, P.R. (eds) Serotonin: Molecular Biology, Receptors and Functional Effects. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7259-1_39
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DOI: https://doi.org/10.1007/978-3-0348-7259-1_39
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