Summary
The effects of serotonin (5-HT) and the 5-HT3 receptor antagonist, BRL 24924, on gastric acid and pepsin secretion were evaluated in conscious dogs with a gastric fistula. In accordance with previous studies serotonin inhibited gastric secretion. BRL 24924 possessed both inhibitory and stimulatory effects depending on the background stimulation. The inhibitory effects of serotonin on gastric secretion were counteracted by BRL 24924 only during infusion of pentagastrin, which by itself releases serotonin. 5-HT3 receptors are of minor importance in the control of gastric secretion.
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References
Andrews, P. L. R., and Hawthorn, J. (1987) Evidence for an extra-abdominal site of action for the 5-HT3-receptor antagonist BRL 24924 in the inhibition of radiation evoked emesis in the ferret. Neuropharmacology 26 (9): 1367–1370.
Bech, K., and Andersen, D. (1985) Effect of serotonin on pentagastrin stimulated gastric acid secretion and gastric antral motility in dogs with gastric fistula. Scand. J. Gastroenterol. 20: 1115–1123.
Bech, K. (1986a) Exogenous serotonin and histamine-stimulated gastric acid and pepsin secretion in dogs. Scand. J. Gastroenterol. 21: 1205–1210.
Bech, K. (1986b) Effect of serotonin on bethanechol stimulated gastric acid secretion and gastric antral motility in dogs. Scand. J. Gastroenterol. 21: 655–661.
Bech, K. (1988) The role of somatostatin and serotonin in the ß-adrenoceptor regulation of gastric function. Dan. Med. Bull. 35 (2): 122–140.
Bech, K., and Johansen, B. (1989) Effects of serotonin on gastric secretion in vivo. In: Vanhoutte, P. M., Paoletti R. (ed.), Serotonin: from cell biology to pharmacology and therapeutics. Amsterdam, Kluwer, pp. 229–233.
Clarke, D. E., Craig, D. A., and Fozard, J. R. (1989) The 5-HT4 receptor: naughty, but nice. Trends Pharmacol. Sci. 10: 385–386.
Dumuis, A., Sebben, M., and Bockaert, J. (1989) The gastrointestinal prokinetic derivatives are agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons. Naunyn-Schmiedeberg’s Arch. Pharmacol. 340: 403–410.
Hawthorn, J., Ostler, K. J., and Andrews, P. L. R. (1988) The role of abdominal visceral innervation and 5-hydroxy-tryptamine M-receptors in vomiting induced by the cytotoxic drugs cyclophosphamide and cis-platin in the ferret. Quart. J. Exp. Physiol. 73: 7–21.
Izzat, A., and Waton, N. G. (1987) Release of 5-hydroxy-tryptamine by pentagastrin and its role in the “fade” of stimulated gastric secretion in cats. J. Physiol. 383: 499–507.
Sanger, G. J. (1987) Increased gut cholinergic activity and antagonism of 5-hydroxytryptamine M-receptors by BRL 24924: potential clinical impotance of BRL 24924. Br. J. Pharmac. 91: 77–87.
Staniforth, D. H., and Corbett, R. (1987) The effect of BRL 24924 on upper gastrointestinal tract activity. Br. J. Clin. Pharmac. 24: 263–264.
Thompson, J. M. (1971) Serotonin and the alimentary tract. Res. Commun. Chem. Pathol. Pharmacol. 2: 687–781.
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© 1991 Birkhäuser Verlag Basel/Switzerland
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Johansen, B., Lyngsø, J.M., Bech, K. (1991). The Effects of BRL 24924 (Renzapride) on Secretion of Gastric Acid and Pepsin in Dogs. In: Fozard, J.R., Saxena, P.R. (eds) Serotonin: Molecular Biology, Receptors and Functional Effects. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7259-1_36
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DOI: https://doi.org/10.1007/978-3-0348-7259-1_36
Publisher Name: Birkhäuser Basel
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Online ISBN: 978-3-0348-7259-1
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