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5-Hydroxytryptamine and the Human Heart

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Serotonin: Molecular Biology, Receptors and Functional Effects

Summary

5-Hydroxytryptamine (5-Ht) causes a variety of effects on human heart through several 5-HT receptor subtypes. Both 5-HT1 -like receptors and 5-HT2 receptors in large coronary arteries mediate spasm. It is likely that vagal 5-HT3 receptors mediate reflex bradycardia while sinoatrial 5-HT4-like receptors mediate tachycardia. Right atrial 5-HT4-like receptors mediate increases in contractile force and relaxation through a cyclic AMP-dependent pathway.

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Authors and Affiliations

  1. SmithKline Beecham Pharmaceutical, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK

    A. J. Kaumann

  2. Clinical Pharmacology Unit, Department of Medicine, Addenbrooke’s Hospital, University of Cambridge, Cambridge, CXB2 2QQ, UK

    A. J. Kaumann

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  1. A. J. Kaumann
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Editors and Affiliations

  1. Preclinical Research, Sandoz Pharma Ltd., P.O. Box 6, CH-4002, Basel, Switzerland

    John R. Fozard

  2. Institute of Pharmacology, Erasmus University Rotterdam, P.O. Box 1738, NL-3000 DR, Rotterdam, The Netherlands

    Pramod R. Saxena

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© 1991 Birkhäuser Verlag Basel/Switzerland

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Kaumann, A.J. (1991). 5-Hydroxytryptamine and the Human Heart. In: Fozard, J.R., Saxena, P.R. (eds) Serotonin: Molecular Biology, Receptors and Functional Effects. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7259-1_35

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  • DOI: https://doi.org/10.1007/978-3-0348-7259-1_35

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7261-4

  • Online ISBN: 978-3-0348-7259-1

  • eBook Packages: Springer Book Archive

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