Summary
In beagle coronary arteries, serotonin-induced contractions are related directly to advancing age from 30 days to 12 years. This change is not associated with age-dependent endothelial disfunction. Contractile responses to serotonin of dog and monkey coronary arteries are evidently greater in the proximal portion than in the distal. Serotonin-induced contractions are in the order of human > monkey > dog arteries. On the other hand, 5-carboxamidotryptamine (5-CT), a 5-HT1 -like receptor agonist, relaxes dog coronary arteries, but contracts the human and monkey arteries. Relaxations of the dog arteries are dependent on endothelium, and are suppressed by methysergide but not altered by ketanserin. Human and monkey artery contractions by 5-CT and serotonin are not potentiated by endothelium denudation, and are attenuated by methysergide and ketanserin. It appears that endothelial serotonergic receptors do not contribute to relaxations in primate coronary arteries, whereas endothelial 5-HT1 -like receptor activation participates in the release of EDRF in dog coronary arteries. Contractions caused by 5-CT in human and monkey coronary arteries may be associated with predominant activation of 5-HT1-like receptor subtypes over 5-HT2 receptors, whereas those by serotonin are due mainly to 5-HT2 receptor activation.
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References
Brazenor, R. M., and Angus, J. A. (1981). Ergometrine contracts isolated canine coronary arteries by a serotonergic mechanism: no role for alpha adrenoceptors. J. Pharmacol. Exp. Ther. 218: 530–536.
Cocks, T. M., and Angus, J. A. (1983). Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin. Nature 305: 627–630.
De Caterina, R., Carpeggiani, C., and L’Abbate, A. (1984). A double-blind, placebo-controlled study of ketanserin in patients with Prinzmetal’s angina. Evidence against role for serotonin in the genesis of coronary vasospasm. Circulation 69: 889–894.
Engel, G., Göthert, M., Müller-Schweinitzer, E., Schliker, E., Sistonen, L., and Stadler, P. A. (1983). Evidence for common pharmacological properties of [3H] 5-hydroxytryptamine binding sites. Presynaptic 5-hydroxytryptamine autoreceptors in CNS and inhibitory presynaptic 5-hydroxytryptamine receptors on sympathetic nerves. Naunyn-Schmiedeberg’s Arch. Pharmacol. 324: 116–124.
Feniuk, W., Humphrey, P. P. A., and Watts, A. D. (1981). Further characterization of pre-and post-junctional receptors for 5-hydroxytryptamine in isolated vasculature. Br. J. Pharmacol. 73: 191.
Ginsburg, R., Bristow, M. R., Davis, K., Dibiase, A., and Billingham, M. E. (1984). Quantitative pharmacologic responses of normal and atherosclerotic isolated human epicardial coronary arteries. Circulation 69: 430–440.
Griffith, T. M., Henderson, A. H., Edwards, D. H., and Lewis, M. J. (1984). Isolated perfused rabbit coronary artery and aortic strip preparations: the role of endothelium-derived relaxant factor. J. Physiol. 351: 13–24.
Heupler, F. A., Proudfit, W. L., Pazavi, M., Shirkey, E. K., Greenstreet, R., and Sheldon, W. C. (1978). Ergonovine maleate provocative test for coronary arterial spasm. Am. J. Cardiol. 41: 631–640.
Houston, D. S., and Vanhoutte, P. M. (1988). Comparison of serotonergic receptor subtypes on the smooth muscle and endothelium of the canine coronary artery. J. Pharmacol. Exp. Ther. 244: 1–10.
Kalsner, S., and Richards, R. (1984). Coronary arteries of cardiac patients are hyperreactive and contain stores of amines: a mechanism for coronary spasm. Science 223: 1435–1437.
Miwa, K., and Toda, N. (1984). Regional differences in the response to vasoconstrictor agents of dog and monkey isolated coronary arteries. Br. J. Pharmacol. 82: 295–301.
Noble, M. I. M., and Drake-Holland, A. J. (1988). Serotonin antagonism prevents myocardial infarction and death from coronary artery disease. Br. Heart J. 59: 100–101.
Shimokawa, H., Aarhus, L. L., and Vanhoutte, P. M. (1987). Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin. Circ. Res. 61: 256–270.
Toda, N., Bian, K., and Inoue, S. (1987). Age-related changes in the response to vasoconstrictor and dilator agents in isolated beagle coronary arteries. Naunyn-Schmiedeberg’s Arch. Pharmacol. 336: 359–364.
Toda, N., and Okamura, T. (1989). Endothelium-dependent and -independent responses to vasoactive substances of isolated human coronary arteries. Am. J. Physiol. 257: H988 — H995.
Toda, N., and Okamura, T. (1990). Comparison of the response to 5-carboxamidotryptamine and serotonin in isolated human, monkey and dog coronary arteries. J. Pharmacol. Exp. Ther. 253: 676–682.
Toda, N., Okamura, T., Shimizu, I., and Tatsuno, Y. (1985). Postmortem functional changes in coronary and cerebral arteries from humans and monkeys. Cardiovasc. Res. 19: 707–713.
Van Nueten, J. M., Janssen, P. A. J., Van Beek, J., Xhonneux, R., Verbeuren, T. J., and Vanhoutte, P. M. (1981). Vascular effects of ketanserin (R41468), a novel antagonist of 5-HT2 serotonergic receptors. J. Pharmacol. Exp. Ther. 218: 217–230.
Van Nueten, J. M., Janssens, W. J., and Vanhoutte, P. M. (1985). Serotonin and vascular smooth muscle. In Vanhoutte, P. M. (ed.), Serotonin and Vascular Smooth Muscle. New York: Raven Press, pp. 95–103.
Van Zwieten, P. A., Blauw, G. J., and Van Brummelen, P. (1990). Pathophysiological relevance of serotonin in cardiovascular diseases. Prog. Pharmacol. Clin. Pharmacol. 7: 63–75.
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© 1991 Birkhäuser Verlag Basel/Switzerland
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Toda, N. (1991). Human, Monkey and Dog Coronary Artery Responses to Serotonin and 5-Carboxamidotryptamine. In: Fozard, J.R., Saxena, P.R. (eds) Serotonin: Molecular Biology, Receptors and Functional Effects. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7259-1_25
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DOI: https://doi.org/10.1007/978-3-0348-7259-1_25
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