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The Electrophysiology of 5-HT

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Book cover Serotonin: Molecular Biology, Receptors and Functional Effects

Summary

A number of 5-HT actions where the mechanism is one of opening an ion channel, resulting in a fast depolarization, a slow depolarization or a hyperpolarization are compared with actions where the mechanism is a closure of ion channels, resulting in a slow depolarization, altered transmitter release or altered membrane accommodation. The relationship of these mechanisms to a particular receptor subtype and to a particular second messenger system is likely to become apparent in the near future. At present, the extent to which differentiation of an electrophysiological action of 5-HT in terms of mechanism is predictive of involvement of a particular 5-HT receptor is unclear. Evidence from the nervous system suggests that a particular mechanism is usually associated with a certain sub-type of 5-HT receptor and, thus, classification by function provides a useful initial framework provided it does not become a dogma.

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Authors and Affiliations

  1. Department of Physiology, University of Wales College of Cardiff, PO Box 902, Cardiff, CF1 1SS, UK

    D. I. Wallis & P. Elliott

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  1. D. I. Wallis
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  2. P. Elliott
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Editors and Affiliations

  1. Preclinical Research, Sandoz Pharma Ltd., P.O. Box 6, CH-4002, Basel, Switzerland

    John R. Fozard

  2. Institute of Pharmacology, Erasmus University Rotterdam, P.O. Box 1738, NL-3000 DR, Rotterdam, The Netherlands

    Pramod R. Saxena

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© 1991 Birkhäuser Verlag Basel/Switzerland

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Wallis, D.I., Elliott, P. (1991). The Electrophysiology of 5-HT. In: Fozard, J.R., Saxena, P.R. (eds) Serotonin: Molecular Biology, Receptors and Functional Effects. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7259-1_19

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  • DOI: https://doi.org/10.1007/978-3-0348-7259-1_19

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7261-4

  • Online ISBN: 978-3-0348-7259-1

  • eBook Packages: Springer Book Archive

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