Skip to main content

Structure and Dynamics of a ~19kD Phosphoprotein, Amelogenin, from Bovine Tooth Enamel

  • Chapter
Water and Ions in Biomolecular Systems

Summary

Structure and dynamics of a hydrophobic protein from bovine tooth enamel with a Mr ~19-20kD is derived from 2D NMR, Molecular mechanics-dynamics, and time-resolved picosecond fluorescence studies. Amelogenin is postulated to contain a hydrophobia core, β-spiral, encapsulated by a hydrophilic coat and seems to act as a Ca++ pump in the early stages of enamel mineralization.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allison, L.A., Moyle, M., Shales, M., and Ingles, C.J. (1985) Cell 42, 599–610.

    Article  Google Scholar 

  • Corden, J.L., Cadena, D.L., Ahearn, J.M., and Dahums, M.E. (1985) Proc. Natl. Acad. Sci. USA 82, 7934–7938.

    Article  Google Scholar 

  • Creutz, C.E., Snyder, S.L., Husted, L.D., Beggerly, L.K., and Fox, J.W. (1988) Biochem. Biphys. Res. Commun. 152, 1298–1303.

    Article  Google Scholar 

  • Deutsch, D. (1989) The Anatomical Record 224, 189–210.

    Article  Google Scholar 

  • Fincham, A.G. and Belcourt, A.B. (1985) In: The Chemistry and Biology of Mineralized Tissues (Butler, W. T., Ed.), Ebsco Media Services, Inc., Birmingham, AL., USA, pp. 240–247.

    Google Scholar 

  • Forde, B.G., Kreis, M., Williamson, M.S., Fry, R.P., Pywell, J., Shewry, P.R., Bunce, M., and Miflin, B. (1985) EMBO J. 4, 9–15.

    Google Scholar 

  • Hutnik, C.M., and Zabo, A.G. (1989) Biochemistry 28, 3923–3934.

    Article  Google Scholar 

  • Ovchinnikov, Yu.A., Abdulaev, N.G., Zolotarev, A.S., Artamonov, I.D., Bespalov, I.A., Dergachev, A.E., and Tsuda, M. (1988) FEBS Lett. 232, 69–72.

    Article  Google Scholar 

  • Rafalski, J.A., Scheets, K., Metzler, M., Peterson, D.M., Hedgcoth, C., and Soll, D.G. (1984) EMBO J. 3, 1409–1415.

    Google Scholar 

  • Renugopalakrishnan, V., Strawích, E.S., Horowitz, P.M., and Glimcher, M.J. (1986) Biochemistry 25, 4879–4887.

    Article  Google Scholar 

  • Renugopalakrishnan, V., Pattabíraman, N., Langridge, R., Strawich, E., Glimcher, M.J., Horowitz, P.M., Zheng, S., Tu, A.T., Huang, S. -G., Prabhakaran, M., Duzgunes, N., and Rapaka, R.s. (1988) In: Recent Progress in Chemistry and Biology of Centrally Acting Peptides (B.N. Dhawan and R.S. Rapaka, Eds.), Central Drug Research Institute, Lucknow, India, pp. 87–107.

    Google Scholar 

  • Renugopalakrishnan, V., Pattabíraman, N., Prabhakaran, M., Strawich, E., and Glimcher, M.J. (1989) Biopolymers 26, 297–303.

    Article  Google Scholar 

  • Singh, U.C. and Kollman, P.A. (1984) J. Computational Chem. 5, 129–149.

    Article  Google Scholar 

  • Shimokawa, H., Ogata, Y., Sasaki, S., Sobel, M.E., MacQuillan, C.I., Termine, J.D., and Young, M.F. (1987) Adv. Dental Res. 20, 2–14.

    Google Scholar 

  • Strawich, E., Poon, P.H., Renugopalakrishnan, V., and Glimcher, M.J. (1985) FEBS Lett. 184, 188–192.

    Article  Google Scholar 

  • Sugeta, H., and Miyazawa, T. (1967) Biopolymers 5, 673–679.

    Article  Google Scholar 

  • Takagi, T., Suzuki, M., Baba, T., Minegishi, K., and Sasaki, S. (1984) Biochem. Biophys. Res. Commun. 121, 592–597.

    Article  Google Scholar 

  • Urry, D.W. (1971) Proc. Natl. Acad. Sci. USA 68, 810–814.

    Article  Google Scholar 

  • Urry, D.W. (1978) Ann. NY Acad. Sci. 307, 3–27.

    Article  Google Scholar 

  • Urry, D.W. (1983) Ultrastructural Pathology 4, 227–251.

    Article  Google Scholar 

  • van Gunsteren, W.F., Berendsen, H.J.C., Hermans, J., Hol, W.G., and Posta, J.P.M., (1983) Proc. Natl. Acad. Sci. USA 80, 4315–4319.

    Article  Google Scholar 

  • Weiner, P.K., Singh, U.C., Kollman, P.A., Caldwell, J., and Cass, D.A. (1984) AMBER (Assisted Model Building with Energy Refinement), University of California San Francisco, Molecular Mechanics and Dynamics Program, University of California, San Francisco, CA, USA.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Birkhäuser Verlag Basel

About this chapter

Cite this chapter

Renugopalakrishnan, V., Prabhakaran, M., Huang, SG., Cheung, H.C., Strawich, E., Glimcher, M.J. (1990). Structure and Dynamics of a ~19kD Phosphoprotein, Amelogenin, from Bovine Tooth Enamel. In: Vasilescu, D., Jaz, J., Packer, L., Pullman, B. (eds) Water and Ions in Biomolecular Systems. Advances in Life Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7253-9_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-7253-9_12

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7255-3

  • Online ISBN: 978-3-0348-7253-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics