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G-Protein-Linked Receptors and Tyrosine Kinase-Mediated Signal Transduction Pathways: A Mid-1990s Perspective, with Working Hypotheses

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Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s

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Summary

G-protein signalling paradigms are reviewed, and data coming from four laboratories are summarized, indicating that G-protein-coupled agonists may act via tyrosine kinase pathways. Approaches to the analysis of these putative G-protein-regulated tyrosine kinase pathways are outlined and working hypotheses are put forward to explain the link between serpentine receptors such as the ones for angiotensin-II, vasopressin and bombesin and the activation of tyrosine kinases such as P125FAK.

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Authors and Affiliations

  1. Endocrine Research Group, Departments of Pharmacology & Therapeutics and Medicine, The University of Calgary, Calgary, AB, Canada, T2N 4N1

    Morley D. Hollenberg (Faculty of Medicine)

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  1. Morley D. Hollenberg
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Editors and Affiliations

  1. Department of Pharmacology and Therapeutics Mclntyre Medical Sciences Building, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6

    A. Claudio Cuello  & Brian Collier  & 

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© 1995 Birkhäuser Verlag Basel/Switzerland

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Hollenberg, M.D. (1995). G-Protein-Linked Receptors and Tyrosine Kinase-Mediated Signal Transduction Pathways: A Mid-1990s Perspective, with Working Hypotheses. In: Cuello, A.C., Collier, B. (eds) Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7218-8_9

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  • DOI: https://doi.org/10.1007/978-3-0348-7218-8_9

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7220-1

  • Online ISBN: 978-3-0348-7218-8

  • eBook Packages: Springer Book Archive

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