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Mechanisms for the Regulation of Inositol Lipid Signaling and Calcium Homeostasis

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Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s

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Summary

Receptor activation of phosphoinositide-specific phospholipase C (PLC) represents a major mechanism for signal transduction in eukaryotic cells. In recent years, considerable progress has been made in the identification and characterization of the individual components of this pathway. Much less information, however, is available regarding mechanisms that may underlie the regulation of this pathway. In this review, some potential mechanisms for the regulation of receptor-stimulated phosphoinositide hydrolysis are discussed. Evidence is presented that regulation of this pathway can occur at the level of either receptor, Gq or PLC.

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Author information

Authors and Affiliations

  1. Neuroscience Laboratory, Mental Health Research Institute and Department of Pharmacology, University of Michigan, Ann Arbor, MI, 48104-1687, USA

    Stephen K. Fisher

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  1. Stephen K. Fisher
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics Mclntyre Medical Sciences Building, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6

    A. Claudio Cuello  & Brian Collier  & 

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© 1995 Birkhäuser Verlag Basel/Switzerland

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Fisher, S.K. (1995). Mechanisms for the Regulation of Inositol Lipid Signaling and Calcium Homeostasis. In: Cuello, A.C., Collier, B. (eds) Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7218-8_8

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  • DOI: https://doi.org/10.1007/978-3-0348-7218-8_8

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7220-1

  • Online ISBN: 978-3-0348-7218-8

  • eBook Packages: Springer Book Archive

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