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Molecular and Cellular Mechanisms in Neurosecretion

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Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s

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Summary

Recent published evidence has increased our understanding on the cellular and molecular mechanisms involved in secretion. It has been demonstrated that the ratios among soluble components of secretory vesicles can be changed according to specific demands and that vesicle contents are released in response to an increase in [Ca2+]i, which is the result of [Ca2+]0 entry through some but not all Ca2+ channels present in neurosecretory cells. It is also clear that target cells modulate the handling of [Ca2+]i by neurosecretory cells. One site of action for Ca2+ is the cytoskeleton. This organelle controls in neurons as well as in other secretory cells, the delivery of secretory vesicles to exocytotic sites. A fine regulation of this process is provided by second messengers and actin associated proteins such as scinderin and synapsin I.

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Authors and Affiliations

  1. Department of Pharmacology, University of Ottawa, Ottawa, Canada, K1H 8M5

    Dr. J.-M. Trifaró

  2. Department of Pharmacology, Universidad Autónoma de Madrid, Madrid, 28029, Spain

    A. G. García

Authors
  1. Dr. J.-M. Trifaró
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  2. A. G. García
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Editors and Affiliations

  1. Department of Pharmacology and Therapeutics Mclntyre Medical Sciences Building, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6

    A. Claudio Cuello  & Brian Collier  & 

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© 1995 Birkhäuser Verlag Basel/Switzerland

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Trifaró, JM., García, A.G. (1995). Molecular and Cellular Mechanisms in Neurosecretion. In: Cuello, A.C., Collier, B. (eds) Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7218-8_28

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  • DOI: https://doi.org/10.1007/978-3-0348-7218-8_28

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7220-1

  • Online ISBN: 978-3-0348-7218-8

  • eBook Packages: Springer Book Archive

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