Summary
In this chapter, we discuss the interactions of food and drugs. The effects of food on the absorption of drugs and the molecular basis by which dietary chemicals affect drug metabolism are discussed. The possible complication of applying information from laboratory studies to humans is discussed together with a recent study on the effect of fasting on chlorzoxazone metabolism. The significant effect of grapefruit juice ingestion on the disposition of dihydropyridine drugs illustrates the possible impact of dietary factors in clinical pharmacology. The important interactions among alcohol, drugs, and nutrients in human health are also discussed.
From the Symposium Dietary Effects on Drug Metabolism at the Xllth International Congress of Pharmacology, Montreal, Canada, July 28, 1994.
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© 1995 Birkhäuser Verlag Basel/Switzerland
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Yang, C.S., Welling, P.G., Wilkinson, G.R., Bailey, D.G., Lieber, C.S. (1995). Dietary Effects on Drug Metabolism. In: Cuello, A.C., Collier, B. (eds) Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7218-8_18
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DOI: https://doi.org/10.1007/978-3-0348-7218-8_18
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