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Calcium Channels, Calcium Channel Antagonists and the Functioning of the Gastrointestinal Tract

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Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s

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Summary

Calcium ions play an essential role in the generation of motor activity of the gastrointestinal tract. Calcium ions enter gastrointestinal smooth muscle cells to activate contractile proteins through voltage-activated ion channels, through ion channels opened by activation of plasma membrane receptors and through release from internal stores. The pharmacology of these pathways is under intense investigation. However, at the moment only drugs that affect voltage dependent calcium channels have reached clinical significance.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada

    Casey Van Breemen

  2. University of Nevada School of Medicine, Reno, Nevada, 89557, USA

    Kenton M. Sanders

  3. Department of Pharmacology, Kyushu University, Fukuoka 812, Japan

    Ryuji Inoue

  4. South Tees Health, Middlesbrough Hospital, Middlesbrough, Cleveland, TS5 5AZ, UK

    Paul A. Cann

  5. Laboratoire de Pharmacologie, Université Catholique de Louvain, B-1200, Brussels, Belgium

    Theophile Godfraind

  6. Laboratoires de thérapeutique moderne L.T.M., Solvay Pharma, 92151, Suresnes Cedex, France

    Marie Odile Christen

Authors
  1. Dr. Jan D. Huizinga
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  2. Casey Van Breemen
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  3. Kenton M. Sanders
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  4. Ryuji Inoue
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  5. Paul A. Cann
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  6. Theophile Godfraind
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  7. Marie Odile Christen
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics Mclntyre Medical Sciences Building, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6

    A. Claudio Cuello  & Brian Collier  & 

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© 1995 Birkhäuser Verlag Basel/Switzerland

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Huizinga, J.D. et al. (1995). Calcium Channels, Calcium Channel Antagonists and the Functioning of the Gastrointestinal Tract. In: Cuello, A.C., Collier, B. (eds) Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7218-8_12

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  • DOI: https://doi.org/10.1007/978-3-0348-7218-8_12

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7220-1

  • Online ISBN: 978-3-0348-7218-8

  • eBook Packages: Springer Book Archive

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