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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques pp 107–165Cite as

The medicinal chemistry and therapeutic potentials of ligands of the histamine H3 receptor

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Abstract

The monoamine histamine is one of the several chemical messengers involved in the concerted regulation of (patho)physiological processes. In rat brain, histamine can be found in a restricted population of neurons originating from the tuberomammillary nucleus of the hypothalamus [1, 2]. These histaminergic neurons project diffusely to several brain areas and are involved in the regulation of physiological functions (e.g. sleep/wakefullness, feeding, cardiovascular control, neuroendocrine control) [1, 2]. In the periphery histamine is mainly found in mast cells, basophils and enterochrommafin cells. Mast cell degranulation after IgG-allergen interactions results in a massive release of histamine, which is responsible for many of the well-known symptoms of allergic conditions [3, 4]. In gastric mucosa histamine is especially stored in enterochromaffin cells, from which it can be release upon stimulation with gastrin or acetylcholine [5]. In turn, histamine stimulates the parietal cell, resulting in gastric acid secretion [5].

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References

  1. J.C. Schwartz, J.M. Arrang, M. Garbarg, H. Pollard, and M. Ruat: Physiol. Rev. 71, 1 (1991).

    PubMed  CAS  Google Scholar 

  2. K. Onodera, A. Yamatodani, T. Watanabe, and H. Wada: Prog Neurobiol. 42, 685 (1994).

    PubMed  CAS  Google Scholar 

  3. P.J. Barnes, in: J. C. Schwartz. and H. L. Haas (Eds.), The histamine receptors, Wiley-Liss, New York (1992), p. 253.

    Google Scholar 

  4. J. Ring, F. Sedlmeier, H. Van der Helm, T. Mayr, U. Walz, H. Ibel, H. Riepel, B. Przybilla, H.J. Reimann, and W. Dorsch, in: J. Ring (Ed.), New Trends in Allergy, Springer-Verlag: Berlin (1985), p. 44.

    Google Scholar 

  5. P.K. Rangachari: Am. J. Physiol. 262, G1 (1992).

    PubMed  CAS  Google Scholar 

  6. S.J. Hill: Pharmacol. Rev. 42, 45 (1990).

    PubMed  CAS  Google Scholar 

  7. R. Leurs, H. Van der Goot, and H. Timmerman, in: B. Testa (Ed.), Advances in Drug Research, Vol. 20. Academic Press: London (1990), p. 217.

    Google Scholar 

  8. A.S.F. Ash and H.O. Schild: Br. J. Pharmac. 27, 427 (1966).

    CAS  Google Scholar 

  9. J.W. Black, W.A.M. Duncan, G.J. Durant, C.R. Ganellin, and M.E. Parsons: Nature 236, 385 (1972).

    PubMed  CAS  Google Scholar 

  10. J.M. Arrang, M. Garbarg, and J.C. Schwartz: Nature 302, 832 (1983).

    PubMed  CAS  Google Scholar 

  11. J.M. Arrang, M. Garbarg, and J.C. Schwartz: Neurosci. 23, 149 (1987).

    CAS  Google Scholar 

  12. K.E. Barke and L.B. Hough: J. Neurochem. 63, 238 (1994).

    PubMed  CAS  Google Scholar 

  13. T. Mochizuki, A. Yamatodani, K. Okakura, M. Takemura, N. Inagaki, and H. Wada: Arch. Pharmacol. 343, 190 (1991).

    CAS  Google Scholar 

  14. Y. Itoh, R. Oishi, M. Nishibori, and K. Saeki: J. Neurochem. 56, 769 (1991).

    PubMed  CAS  Google Scholar 

  15. H. Prast, M. Prast, and A. Philippu: Agents Actions 41, C64 (1994).

    PubMed  CAS  Google Scholar 

  16. J.M. Arrang, M. Garbarg, J.C. Lancelot, J.M. Lecomte, H. Pollard, M. Robba, W. Schunack, and J.C. Schwartz: Nature 327, 117 (1987).

    PubMed  CAS  Google Scholar 

  17. M. Garbarg, J.M. Arrang, A. Rouleau, X. Ligneau, M.D.T. Tuong, J.C. Schwartz, and C.R. Ganellin: J. Pharmacol. Exp. Ther. 263, 304 (1992).

    PubMed  CAS  Google Scholar 

  18. H. Yokoyama, K. Onodera, K. Maeyama, E. Sakurai, K. Iinuma, R. Leurs, H. Tim-merman, and T. Watanabe: Eur. J. Pharmacol. 260, 23 (1994).

    PubMed  CAS  Google Scholar 

  19. N. Sakai, K. Onodera, K. Maeyama, K. Yanai, and T. Watanabe: Life Sci. 48, 2397 (1991).

    PubMed  CAS  Google Scholar 

  20. R. Oishi, Y. Itoh, M. Nishibori, and K. Saeki: J. Neurochem. 52, 1388 (1989).

    PubMed  CAS  Google Scholar 

  21. M. Garbarg, M.D. Trung Tuong, C. Gros, and J.C. Schwartz: Eur. J. Pharmacol. 164, 1 (1989).

    PubMed  CAS  Google Scholar 

  22. N. Sakai, A. Sakurai, E. Sakurai, K. Yanai, K. Maeyama, and T. Watanabe: Biochem. Biophys. Res. Commun. 185, 121 (1992).

    PubMed  CAS  Google Scholar 

  23. T. Mochizuki, K. Okakuramochizuki, A. Horii, Y. Yamamoto, and A. Yamatodani: J. Neurochem. 62, 2275 (1994).

    PubMed  CAS  Google Scholar 

  24. J. Clapham and G.J. Kilpatrick: Br. J. Pharmacol. 107, 919 (1992).

    PubMed  CAS  Google Scholar 

  25. E. Schlicker, B. Malinowska, M. Kathmann, and M. Gothert: Fundam. Clin. Pharmacol. 8, 128 (1994).

    PubMed  CAS  Google Scholar 

  26. E. Schlicker, K. Fink, M. Detzner, and M. Gothert: J. Neural. Transm. 93, 1 (1993).

    CAS  Google Scholar 

  27. E. Schlicker, K. Fink, M. Hinterthaner, and M. Göthert: Arch. Pharmacol. 340, 633 (1989).

    CAS  Google Scholar 

  28. E. Schlicker, A. Behling, G. Lümmen, and M. Göthert: Arch. Pharmacol. 345, 489 (1992).

    CAS  Google Scholar 

  29. E. Schlicker, R. Betz, and M. Göthert: Arch. Pharmacol. 337, 588 (1988).

    CAS  Google Scholar 

  30. G. Bertaccini, G. Coruzzi, and E. Poli: Aliment. Pharmacol. Therap. 5, 585 (1991).

    CAS  Google Scholar 

  31. R.C. Vollinga, O.P. Zuiderveld, H. Scheerens, A. Bast, and H. Timmerman: Meth. Find. Exp. Clin. Pharmacol. 14, 747 (1992).

    CAS  Google Scholar 

  32. M. Ichinose, C.D. Stretton, J.C Schwartz, and P.J. Barnes: Br. J. Pharmacol. 97, 13 (1989).

    PubMed  CAS  Google Scholar 

  33. G. Coruzzi, E. Poli, and G. Bertaccini: J. Pharmacol. Exp. Ther. 258, 325 (1991).

    PubMed  CAS  Google Scholar 

  34. E. Poli, G. Coruzzi, and G. Bertaccini: Life Sci. 48, PL63 (1991).

    PubMed  CAS  Google Scholar 

  35. E. Schlicker, W. Schunack, and M. Göthert: Arch. Pharmacol. 342, 497 (1990).

    CAS  Google Scholar 

  36. G.J. Molderings, G. Weissenborn, E. Schlicker, J. Likungu, and M. Gothert: Arch. Pharmacol. 346, 46 (1992).

    CAS  Google Scholar 

  37. H. Schworer, S. Katsoulis, and K. Racke: Gastroenterology 102, 1906 (1992).

    PubMed  CAS  Google Scholar 

  38. V. Dimitriadou, A. Rouleau, M.D.T. Tuong, G.J.F. Newlands, H.R.P. Miller, G. Luffau, J.C. Schwartz, and M. Garbarg: Clin. Sci. 87, 151 (1994).

    PubMed  CAS  Google Scholar 

  39. M. Ichinose and P.J. Barnes: Eur. J. Pharmacol. 174, 49 (1989).

    PubMed  CAS  Google Scholar 

  40. S.J. Taylor and G.J. Kilpatrick: Br. J. Pharmacol. 105, 667 (1992).

    PubMed  CAS  Google Scholar 

  41. R. Leurs, M.M. Brozius, M.J. Smit, A. Bast, and H. Timmerman: Br. J. Pharmacol, 102, 179 (1991).

    PubMed  CAS  Google Scholar 

  42. G.J. Menkveld and H. Timmerman: Eur. J. Pharmacol. 186, 343 (1990).

    PubMed  CAS  Google Scholar 

  43. J.G. Van der Werf, G.J. Bijloo, A. Van der Vliet, A. Bast, and H. Timmerman: Agents Actions 20, 239 (1987).

    PubMed  Google Scholar 

  44. J.C. Eriks, H. Van der Goot, G.J. Sterk, and H. Timmerman: J. Med. Chem. 35, 3239 (1992).

    PubMed  CAS  Google Scholar 

  45. R. Lipp, H. Stark, and W. Schunack, in: J.C. Schwartz and H.L. Haas (Eds.), Receptor Biochemistry and Methodology, Wiley-Liss, New York (1992), p. 57.

    Google Scholar 

  46. R. Lipp, J.M. Arrang, M. Garbarg, P. Luger, J.C. Schwartz, and W. Schunack: J. Med. Chem. 35, 4434 (1992).

    PubMed  CAS  Google Scholar 

  47. R. Lipp, J.M. Arrang, J. Buschmann, M. Garbarg, P. Luger, W. Schunack, and J.C. Schwartz, in: H. Timmerman and H. Van der Goot (Eds.), New perspectives in Histamine Research, Birkhauser Verlag: Basel (1991), p. 277.

    Google Scholar 

  48. J.M. Arrang, M. Garbarg, J.C. Schwartz, R. Lipp, H. Stark, W. Schunack, and J.M. Lecomte, in: H. Timmerman and H. Van der Goot (Eds.), New Perspectives in Histamine Research, Birkhauser Verlag: Basel (1991), p.55.

    Google Scholar 

  49. J. M. Arrang, M. Garbarg, W. Schunack, J.C. Schwartz, and R. Lipp, (1987), Eur. Patent Appl. pO214058.

    Google Scholar 

  50. N.-Y. Shih, R. Aslanian, A.T. Lupo Jr., L. Duguma, S. Orlando, J.J. Piwinski, M.J. Green, A.K. Ganguly, M. Clark, S. Tozzi, W. Kreutner, and J.A. Hey. Poster presented at New Perspectives in Histamine Research 1994. Riding Mountain National Park, Manitoba, Canada.

    Google Scholar 

  51. A. Korte, J. Myers, N.Y. Shih, R.W. Egan, and M.A. Clark: Biochem. Biophys. Res. Comm. 168, 979 (1990).

    PubMed  CAS  Google Scholar 

  52. A. Burger, M. Bernabe, and P.W. Collins: J. Med. Chem. 13, 33 (1970).

    PubMed  CAS  Google Scholar 

  53. J.C. Schwartz, J.M. Arrang, M. Garbarg, and W. Schunack, in: A.E Harms (Ed.), Innovative Approaches in Drug Research, Elsevier Science Publishers BV: Amsterdam (1986), p.73.

    Google Scholar 

  54. J.M. Arrang, J.C. Schwartz, and W. Schunack: Eur. J. Pharmacol. 117, 109 (1985).

    PubMed  CAS  Google Scholar 

  55. J.F. Van der Werf, A. Bast, G.J. Bijloo, A. Van der Vliet, and H. Timmerman: Eur. J. Pharmacol. 138, 199 (1987).

    PubMed  Google Scholar 

  56. N.Y. Shih, Int. Patent Appl. (PCT) (1993) p. WO 93.

    Google Scholar 

  57. H. Van der Goot, M.J.P. Schepers, G.J. Sterk, and H. Timmerman: Eur. J. Med. Chem. 27,511(1992).

    Google Scholar 

  58. W. Howson, M.E. Parsons, P. Raval, and G.T.G. Swayne: Bioorg. Med. Chem. Lett. 2, 77 (1992).

    CAS  Google Scholar 

  59. C.R. Ganellin, B. Bangandersen, Y.S. Khalaf, W. Tertiuk, J.M. Arrang, M. Garbarg, X. Ligneau, A. Rouleau, and J.C. Schwartz: Bioorg. Med. Chem. Lett. 2, 1231 (1992).

    CAS  Google Scholar 

  60. R. Leurs and H. Timmerman: Prog. Drug Res. 39, 127 (1992).

    PubMed  CAS  Google Scholar 

  61. R.C. Vollinga, J.P. De Koning, F.P Jansen, R. Leurs, W.M.P.B. Menge, and H. Timmerman: J. Med. Chem. 37, 332 (1994).

    PubMed  CAS  Google Scholar 

  62. N.Y Shih, Int. Patent Appl. (PCT) (1993), p. WO 93.

    Google Scholar 

  63. N.Y Shih, Int. Patent Appl. (PCT) (1993). p. WO 93.

    Google Scholar 

  64. R. Lipp, W. Schunack, and J.M. Arrang: Poster presented at Xth Int. Symp. Med. Chem. Budapest, 239 (1988).

    Google Scholar 

  65. R.C. Vollinga, W.M.P.B. Menge, R. Leurs, and H. Timmerman: J. Med. Chem. 38, 266 (1995).

    PubMed  CAS  Google Scholar 

  66. R.C. Vollinga: (unpublished results).

    Google Scholar 

  67. J.M. Arrang, M. Garbarg, J.C.M. Lancelot, J.M. Lecomte, M.E Robba, and J.C. Schwartz, Eur. Pat. Appl. (1986) p. EP 0.

    Google Scholar 

  68. W.M.P.B. Menge, H. Van der Goot, H. Timmerman, J.L.H. Eersels, and J.D.M. Herscheid: J. Lab. Comp. Radiopharm. 31, 781 (1992).

    CAS  Google Scholar 

  69. F.P. Jansen, B. Rademaker, A. Bast, and H. Timmerman: Eur. J. Pharmacol. 217, 203 (1992).

    PubMed  CAS  Google Scholar 

  70. F.P. Jansen, W. T. S., H. P. Voss, H. W.M. Steinbusch, R. C. Vollinga, B. Rademaker, A. Bast, and H. Timmerman: Br. J. Pharmacol. 113, 355 (1994).

    PubMed  CAS  Google Scholar 

  71. J. C. Schwartz, J. M. Arrang, M. Garbarg, J.M. Lecomte, C.R. Ganellin, A. Fkyerat, W. Tertiuk, W. Schunack, R. Lipp, H. Stark, and K. Puran, Int. Patent Appl. (PCT) (1993) p. WO 93.

    Google Scholar 

  72. E. Schlicker, M. Kathmann, S. Reidemeister, H. Stark, and W. Schunack: Br. J. Pharmacol. 112, 1043 (1994).

    PubMed  CAS  Google Scholar 

  73. J.C. Schwartz, J.M. Arrang, M. Garbarg, and H. Pollard: Agents Actions 30, 13 (1990).

    PubMed  CAS  Google Scholar 

  74. R.C. Vollinga, W.M.P.B. Menge, R. Leurs, and H. Timmerman: J. Med. Chem. 38, 2244 (1995).

    PubMed  CAS  Google Scholar 

  75. E. Barocelli, V. Ballabeni, A. Caretta, F. Bordi, C. Silva, G. Morini, and M. Impicciatore: Agents Actions 38, 158 (1993).

    PubMed  CAS  Google Scholar 

  76. Y.S. Khalaf, C.R. Ganellin, S.K. Hosseini, W. Tertiuk, J.M. Arrang, and N. Defontaine. Presented at European Histamine Research Society XIXth Annual Meeting. 1990, Kuopio, Finland.

    Google Scholar 

  77. F. Bordi, M. Mor, P.V. Plazzi, C. Silva, G. Morini, A. Caretta, E. Barocelli, and M. Impicciatore: Farmaco 47, 1343 (1992).

    PubMed  CAS  Google Scholar 

  78. M. Amin Khan, G.J. Durant, S. Ghodsi-Hovseplan, A.A. El-Assadi, W. Hoss, W.S. Messer jr., and R. C. A. Frederickson: Med. Chem. Res. 3, 428 (1993).

    CAS  Google Scholar 

  79. H. Stark, R. Lipp, W. Schunack, J.M. Arrang, N. Defontaine, and J.C Schwartz: Poster presented at New Perspectives in Histamine Research 1990. Noordwijkerhout, The Netherlands.

    Google Scholar 

  80. R. Mierzwa, A. King, M.A. Conover, S. Tozzi, M.S. Puar, M. Patel, S.J. Coval, and S.A. Pomponi: J. Nat. Prod-Lloydia 57, 175 (1994).

    CAS  Google Scholar 

  81. M. Kathmann, E. Schlicker, M. Detzner, and H. Timmerman: Arch. Pharmacol. 348, 498 (1993).

    CAS  Google Scholar 

  82. S. A. Pomponi, V.P. Gullo, A.C. Horan, M.G. Patel, and S. Coval, US Patent (1993), Fla. p.5.

    Google Scholar 

  83. K. Purand, H. Stark, X. Ligneau, M. Garbarg, J.C Schwartz, and W. Schunack: Poster presented at European Histamine Research Society XXIIIrd Annual Meeting 1994. Budapest, Hungary.

    Google Scholar 

  84. X. Ligneau, M. Garbarg, M.L. Vizuette, J. Diaz, K. Purand, H. Stark, W. Schunack, and J.C Schwartz: J. Pharmacol. Exp. Ther. 271, 452 (1994).

    PubMed  CAS  Google Scholar 

  85. A. Hüls, K. Purand, H. Stark, X. Ligneau, M. Garbarg, J.C. Schwartz, and W. Schunack: Poster presented at European Histamine Research Society XXIIIrd Annual Meeting 1994. Budapest, Hungary.

    Google Scholar 

  86. W. Schunack, K. Purand, A. Hüls, H. Stark, X. Ligneau, M. Garbarg, and J.C. Schwartz: Poster presented at XIIth Int. Congress of Pharmacology (IUPHAR) 1994. Montreal, Quebec, Canada.

    Google Scholar 

  87. M. Kathmann, E. Schlicker, and M. Gothert: Psychopharmacology 116, 464 (1994).

    PubMed  CAS  Google Scholar 

  88. A. Alves Rodrigues, F.P. Jansen, R. Leurs, H. Timmerman, and G.D. Prell: Br. J. Pharmacol. 114, 1523 (1995).

    PubMed  CAS  Google Scholar 

  89. J.M. Arrang, M. Garbarg, T.T. Quach, M. Dam Trung Tuong, E. Yeramian, and J.C. Schwartz: Eur. J. Pharmacol. 111, 73 (1985).

    PubMed  CAS  Google Scholar 

  90. J.M. Arrang, J. Roy, J.L. Morgat, W. Schunack, and J.C. Schwartz: Eur. J. Pharmacol. 188, 219 (1990).

    PubMed  CAS  Google Scholar 

  91. G.J. Kilpatrick and A.D. Michel, in: H. Timmerman and H. van der Goot (Eds.), New Perspectives in Histamine Research, Birkhäuser Verlag, Basel (1991), p. 69.

    Google Scholar 

  92. R.E. West, A. Zweig, R.T. Granzow, M.I. Siegel, and R.W. Egan: J. Neurochem. 55, 1612 (1990).

    PubMed  CAS  Google Scholar 

  93. R.E. West, A. Zweig, N.-Y. Shih, M.I. Siegel, R.W. Egan, and M. A. Clark: Mol. Pharmacol. 38, 610 (1990).

    PubMed  CAS  Google Scholar 

  94. A. Zweig, M.I. Siegel, R.W. Egan, M.A. Clark, R.G.L. Shorr, and R.E. West: J. Neu-roehem. 59, 1661 (1992).

    CAS  Google Scholar 

  95. P. Cumming, C. Shaw, and S.R. Vincent: Synapse 8, 144 (1991).

    PubMed  CAS  Google Scholar 

  96. G. Barbin, J.M. Palacois, E. Rodergas, J.C. Schwartz, and M. Garbarg: Mol. Pharmacol. 18, 1 (1980).

    PubMed  CAS  Google Scholar 

  97. W.G. Sinkins, M. Kandel, S.I. Kandel, W. Schunack, and J.W. Wells: Mol. Pharmacol. 43, 569 (1993).

    PubMed  CAS  Google Scholar 

  98. M.I. Martinez-Mir, H. Pollard, J. Moreau, J.M. Arrang, M. Ruat, E. Traiffort, J. C. Schwartz, and J. M. Palacois: Brain Res. 526, 322 (1990).

    PubMed  CAS  Google Scholar 

  99. H. Pollard, J. Moreau, J.M. Arrang, and J.C. Schwartz: Neuroscience 52, 169 (1993).

    PubMed  CAS  Google Scholar 

  100. Y. Nakagawa, K. Yanai, J.H. Ryu, M. Kiyosawa, M. Tamai, and T. Watanabe: Brain Res. 643, 74 (1994).

    PubMed  CAS  Google Scholar 

  101. P. Cumming and S.R. Vincent: Brain Res. 602, 53 (1993).

    PubMed  CAS  Google Scholar 

  102. K. Yanai, J.H. Ryu, N. Sakai, T. Takahashi, R. Iwata, T. Ido, K. Murakami, and T. Watanabe: Jpn. J. Pharmacol. 65, 107 (1994).

    PubMed  CAS  Google Scholar 

  103. J.C Barnes, J.D. Brown, N.P. Clarke, J. Clapham, D.J. Evans, and C.T. Oshaughnessy: Eur. J. Pharmacol. 250, 147 (1993).

    PubMed  CAS  Google Scholar 

  104. M. Ruat, M. Korner, M. Garbarg, C. Gros, J.C. Schwartz, W. Tertiuk, and C.R. Ganellin: Proc. Natl. Acad. Sci. 85, 2743 (1988).

    PubMed  CAS  Google Scholar 

  105. M. Ruat, E. Traiffort, M.L. Bouthenet, J.C. Schwartz, J. Hirschfeld, A. Buschauer, and W. Schunack: Proc. Natl. Acad. Sci. 87, 1658 (1990).

    PubMed  CAS  Google Scholar 

  106. Y. Cherifi, C. Pigeon, M. Leromancer, A. Bado, F. Reyldesmars, and M.J.M. Lewin: J. Biol. Chem. 267, 25315 (1992).

    PubMed  CAS  Google Scholar 

  107. M. Yamashita, H. Fukui, K. Sugama, Y. Horio, S. Ito, H. Mizuguchi, and H. Wada: Proc. Natl. Acad. Sci. USA 88, 11515 (1991).

    PubMed  CAS  Google Scholar 

  108. M. Ruat, E. Traiffort, J.M. Arrang, R. Leurs, and J.C. Schwartz: Biochem. Biophys. Res. Commun. 179, 1470 (1991).

    PubMed  CAS  Google Scholar 

  109. I. Gantz, M. Schaffer, J. DelValle, G. Logdson, V. Campbell, M. Uhler, and T. Yamada: Proc. Natl. Acad. Sci. USA 88, 429 (1991).

    PubMed  CAS  Google Scholar 

  110. I. Gantz, G. Munzert, T. Tashiro, M. Schaffer, L. Wang, J. DelValle, and T. Yamada: Biochem. Biophys. Res. Commun. 178, 1386 (1991).

    PubMed  CAS  Google Scholar 

  111. H. Fukui, K. Fujimoto, H. Mizuguchi, K. Sakamoto, Y. Horio, S. Takai, K. Yamada, and S. Ito: Biochem. Biophys. Res. Commun. 201, 894 (1994).

    PubMed  CAS  Google Scholar 

  112. K. Fujimoto, Y. Horio, K. Sugama, S. Ito, Y.Q. Liu, and H. Fukui: Biochem. Biophy.s Re.s Commun. 190, 294 (1993).

    CAS  Google Scholar 

  113. M.D. Debacker, W. Gommeren, H. Moereels, G. Nobels, P. Vangompel, J.E. Leysen, and W.H.M.L. Luyten: Biochem. Biophys. Res. Commun. 197, 1601 (1993).

    CAS  Google Scholar 

  114. H. Schworer, A. Reimann, G. Ramadori, and K. Racke: Arch. Pharmacol. 350, 375 (1994).

    CAS  Google Scholar 

  115. H.H. Dale and P.P. Laidlaw: J. Physiol. 41, 318 (1910).

    PubMed  CAS  Google Scholar 

  116. D. Bovet and A.M. Staub: C.R. Soc. Biol. 124, 547 (1937).

    CAS  Google Scholar 

  117. S.B. Felix, A. Buschauer, and G. Baumann, in: H. Timmerman. and H. Van der Goot (Eds.), New perspectives in histamine research, Birkhäuser Verlag: Basel (1991), p. 257.

    Google Scholar 

  118. H. Timmerman: J. Med. Chem. 33, 4 (1990).

    PubMed  CAS  Google Scholar 

  119. J.L. Burgaud and N. Oudart: Brit. J. Pharmacol. 109, 960 (1993).

    CAS  Google Scholar 

  120. M. Ichinose and P.J. Barnes: J. Allerg. Clin. Immunol. 86, 491 (1990).

    CAS  Google Scholar 

  121. J.A. Hey, M. Del Prado, R.W. Egan, W. Kreutner, and R.W. Chapman: Eur. J. Pharmacol. 211, 421 (1992).

    PubMed  CAS  Google Scholar 

  122. J.P Trzeciakowski: J. Pharm. Exp. Therap. 243, 874 (1987).

    CAS  Google Scholar 

  123. M.J.M. Lewin, A. Bado, Y. Cherifi, and F. Reyldesmars: J. Biol. Med. 65, 607 (1992).

    CAS  Google Scholar 

  124. A. Bado, F. Hervatin, and M.J.M. Lewin: Am. J. Physiol. 260, G631 (1991).

    PubMed  CAS  Google Scholar 

  125. G. Soldani, G. Mengozzi, L. Intorre, G. De Giorgi, G. Coruzzi, and G. Bertaccini: Arch. Pharmacol. 347, 61 (1993).

    CAS  Google Scholar 

  126. G. Soldani, L. Intorre, S. Bertini, E. Luchetti, G. Coruzzi, and G. Bertaccini: Arch. Pharmacol. 350, 218 (1994).

    CAS  Google Scholar 

  127. F. Hollande, J.P. Ball, and R. Magous: Am. J. Physiol. 265, G1039 (1993).

    PubMed  CAS  Google Scholar 

  128. G. Coruzzi, M. Adami, and G. Bertaccini: Pharmacol. 44, 190 (1992).

    CAS  Google Scholar 

  129. T. Mochizuki, A. Yamatodani, K. Okakura, A. Horii, N. Inagaki, and H. Wada: Physiol. Behav. 51, 391 (1992).

    PubMed  CAS  Google Scholar 

  130. A.N. Nicholson, P.A. Pascoe, C. Turner, C.R. Ganellin, P.M. Greengrass, A.F. Casy, and A.D. Mercer: Br. J. Pharmacol. 104, 270 (1991).

    PubMed  CAS  Google Scholar 

  131. J.S. Lin, K. Sakai, G. Vannimercier, J.M. Arrang, M. Garbarg, J.C. Schwartz, and M. Jouvet: Brain Res. 523, 325 (1990).

    PubMed  CAS  Google Scholar 

  132. J.C. Lin, K. Sakai, and M. Louvet: C. R. Acad. Sci. 303, 469 (1986).

    CAS  Google Scholar 

  133. H. Yokoyama, K. Onodera, K. Iinuma, and T. Watanabe: Pharmacol. Biochem. Behav. 47, 503 (1994).

    PubMed  CAS  Google Scholar 

  134. K. Iinuma, H. Yokoyama, T. Otsuki, K. Yanai, T. Watanabe, T. Ido, and M. Itoh: Lancet 341, 238 (1993).

    PubMed  CAS  Google Scholar 

  135. H. Yokoyama, K. Onodera, K. Iinuma, and T. Watanabe: Eur. J. Pharmacol. 234, 129 (1993).

    PubMed  CAS  Google Scholar 

  136. T. Sakata, K. Ookuma, K. Fujimoto, K. Fukagawa, and H. Yoshimatsu: Brain Res. Bull. 27, 371 (1991).

    PubMed  CAS  Google Scholar 

  137. T. Doi, T. Sakata, H. Yoshimatsu, H. Machidori, M. Kurokawa, L.A.L.W. Jayasekara, and N. Niki: Brain Res. 641, 311 (1994).

    PubMed  CAS  Google Scholar 

  138. A. Oohara, H. Yoshimatsu, M. Kurokawa, R. Oishi, K. Saeki, and T. Sakata: J. Neurochem. 63, 677 (1994).

    PubMed  CAS  Google Scholar 

  139. T. Yabe, C. De Waele, M. Serafin, N. Vibert, J.M. Arrang, M. Muhlethaler, and P.P. Vidal: Exp. Brain. Res. 93, 249 (1993).

    PubMed  CAS  Google Scholar 

  140. A.J.E.M. Fischer: Acta Otolaryngol. 479, 24 (1991).

    CAS  Google Scholar 

  141. M.A.M.R. De Almeida and I. Izquierdo: Arch. Int. Pharmacodyn. 283, 193 (1986).

    PubMed  Google Scholar 

  142. M.A.M.R. De Almeida and I. Izquierdo: Arch. Int. Pharmacodyb. 291, 202 (1988).

    Google Scholar 

  143. J.M. Bekkers: Science 261, 104 (1993).

    PubMed  CAS  Google Scholar 

  144. V.S. Vorobjev, I.N. Sharonova, I.B. Walsh, and H.L. Haas: Neuron 11, 837 (1993).

    PubMed  CAS  Google Scholar 

  145. R.E. Brown, H.L. Haas, and K.G. Reymann: Soc. Neurosci. Abstr. 20, 1515 (1994).

    Google Scholar 

  146. I.M. Mazurkiewicz-Kwilecki and S. Nsonwah: Can. J. Physiol. Pharmacol. 67, 75 (1989).

    PubMed  CAS  Google Scholar 

  147. L.M. Bierer, V. Haroutunian, S. Gabriel, P.J. Knott, L.S. Carlin, D.P. Purohit, D.P. Perl, J. Schmeidler, P. Kanof, and K.L. Davis: J. Neurochem. 64, 749 (1995).

    PubMed  CAS  Google Scholar 

  148. J.C. Barnes, J. Clapham, R.P. Dennes, G.L. Kilpatrick, F.H. Marshall, C.T. O’Shaughnessy, and E. Cavicchini: Soc. Neurosci. Abstr. 19, P1813 (1993).

    Google Scholar 

  149. C.P.S. Smith, A.J. Hunter, and G.W Bennett: Psychopharmacology 114, 651 (1994).

    PubMed  CAS  Google Scholar 

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  1. Leiden/Amsterdam Center for Drug Research, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands

    R. Leurs, R. C. Vollinga & H. Timmerman

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    E. Jucker

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Leurs, R., Vollinga, R.C., Timmerman, H. (1995). The medicinal chemistry and therapeutic potentials of ligands of the histamine H3 receptor. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 45. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7164-8_4

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  • DOI: https://doi.org/10.1007/978-3-0348-7164-8_4

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