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Carcinogenicity, mutagenicity and cancer preventing activities of flavonoids: A structure-system-activity relationship (SSAR) analysis

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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

Abstract

Flavonoids and related phenolic compounds are widely distributed among vascular plants and are found in numerous fruits, grains vegetables and other parts of higher plants [1–3]. Isolation and structural determination of flavonoids have been employed in plant taxonomy [1, 2]. Because of the wide range of chemical structures of flavonoids, coupled with a variety of test systems and different dose levels used, sometimes conflicting reports have been published in the literature regarding their numerous pharmacological and toxicological activities. This prompted us to conduct a literature survey and a structure-system-activity-relationship (SSAR) analysis of existing data, with particular emphasis on the carcinogenicity/mutagenicity and cancer preventive aspects of the flavonoids.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA, 90033, USA

    A. Das & E. J. Lien

  2. Visiting Research Scholar from School of Pharmacy, Beijing Medical University, China

    J. H. Wang

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  1. A. Das
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  2. J. H. Wang
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  3. E. J. Lien
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  1. Basel, Switzerland

    Ernst Jucker

  2. Steinweg 28, CH-4107, Ettingen, Switzerland

    Ernst Jucker

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© 1994 Birkhäuser Verlag Basel (Switzerland)

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Das, A., Wang, J.H., Lien, E.J. (1994). Carcinogenicity, mutagenicity and cancer preventing activities of flavonoids: A structure-system-activity relationship (SSAR) analysis. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 42. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7153-2_5

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  • DOI: https://doi.org/10.1007/978-3-0348-7153-2_5

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7155-6

  • Online ISBN: 978-3-0348-7153-2

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