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Design and discovery of new drugs by stepping-up and stepping-down approaches

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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

Abstract

Numerous alkaloids are known to have significant pharmacological effects, perhaps due to the fact that many neurotransmitters and some hormones (e.g. acetylcholine, epinephrine, serotonin, dopamine, histamine, γ-aminobutyric acid, etc.) [1] have a positively charged nitrogen atom under physiological conditions. Many alkaloids have not only served as therapeutical agents but also as lead compounds to other synthetic medicinal agents. In general, the synthetic compounds are of less structural complexity. For examples, many local anesthetics are derived from cocaine, anticholinergics are from atropine and narcotic analgesics are from morphine (see Figure 1).

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90033, USA

    Eric J. Lien

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  1. Eric J. Lien
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  1. Basel, Switzerland

    Ernst Jucker

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© 1993 Birkhäuser Verlag Basel

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Lien, E.J. (1993). Design and discovery of new drugs by stepping-up and stepping-down approaches. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 40. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7147-1_6

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  • DOI: https://doi.org/10.1007/978-3-0348-7147-1_6

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7149-5

  • Online ISBN: 978-3-0348-7147-1

  • eBook Packages: Springer Book Archive

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