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Characteristics of catechol O-methyltransferase (COMT) and properties of selective COMT inhibitors

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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

Abstract

The enzyme-catalyzed O-methylation of catecholamines was first described by Axelrod and coworkers in the late 1950’s [1–3]. They called the responsible enzyme catechol O-methyltransferase (COMT). During the subsequent 15 years the enzyme was partially purified, its distribution was established, several reaction mechanisms were proposed, and a number of inhibitors were described. The results of this study period were extensively reviewed by Guldberg and Marsden in 1975 [4].

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Helsinki, Siltavuorenpenger 10 A, SF-00170, Helsinki 17, Finland

    P. T. Männistö

  2. Orion Pharmaceutica, Research Center, Orionintie 1, SF-02101, Espoo, Finland

    I. Ulmanen, K. Lundström, J. Taskinen, J. Tenhunen & C. Tilgmann

  3. Department of Neurology, University of Helsinki, Haartmaninkatu 4, SF-00290, Helsinki, Finland

    S. Kaakkola

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Männistö, P.T. et al. (1992). Characteristics of catechol O-methyltransferase (COMT) and properties of selective COMT inhibitors. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 39. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7144-0_9

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