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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques pp 197–217Cite as

Mechanisms of fibrinolysis and clinical use of thrombolytic agents

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Abstract

Myocardial infarction, stroke, and pulmonary embolism are among the leading causes of mortality and morbidity in western countries [1–4]. These disorders have, as their underlying etiology, the occlusion of blood vessels by a clot (thrombosis). One approach to the treatment of thrombosis is the pharmacological dissolution of the clot (thrombolysis), by substances that activate the fibrinolytic system. This system leads to the conversion of the inactive proenzyme plasminogen, to plasmin. Plasmin degrades fibrin into soluble degradation products. To clarify the steps of this complex lytic mechanism, an introduction to the biochemistry and physiology of fibrinolysis and of its components will be provided. This is important to a better understanding of the mechanisms of the effect of currently available thrombolytic agents as well as to newer achievements in the area of thrombolysis.

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Authors and Affiliations

  1. Clinica Medica, Istituto di Medicina Interna e Malattie Dismetaboliche, Napoli, Italy

    Maurizio Margaglione, Elvira Grandone & Giovanni Di Minno

  2. I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

    Maurizio Margaglione, Elvira Grandone & Giovanni Di Minno

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  1. Maurizio Margaglione
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  2. Elvira Grandone
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  3. Giovanni Di Minno
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  1. Basel, Switzerland

    Ernst Jucker

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Margaglione, M., Grandone, E., Di Minno, G. (1992). Mechanisms of fibrinolysis and clinical use of thrombolytic agents. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 39. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7144-0_6

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  • DOI: https://doi.org/10.1007/978-3-0348-7144-0_6

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