Skip to main content
SpringerLink
Log in

The effects of NSAIDs and E-prostaglandins on bone: A two signal hypothesis for the maintenance of skeletal bone

  • Chapter
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

Abstract

Since the formulation of the Raisz hypothesis asserting that prostaglandin-E (PGE) was responsible for bone resorption [1], arachidonic acid metabolites, particularly PGE2 have been the focus of a great number of experimental bone studies. Primarily carried out in vitro, these studies showed that particular cyclooxygenase products are the mediators of osteoclast activity and consequently bone resorption. Considerable data, especially whole animal studies, dispute this widely held hypothesis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. D. C. Klein and C. G. Raisz: Endocrinology, 86, 1436 (1970).

    Article  Google Scholar 

  2. W. S. S. Jee, K. Ueno, Y. P. Deng, and D. M. Woodbury: Calcif. Tiss. Int., 37, 148–157 (1985).

    Google Scholar 

  3. W. S. S. Jee, K. Ueno, D. B. Kimmel, D. M. Woodbury, P. Price, and L. A. Woodbury: Bone, 8, 171–178 (1987).

    Article  Google Scholar 

  4. W. S. S. Jee, X. J. Li, and L. I. Li: Bone, 9, 381 (1988).

    Article  Google Scholar 

  5. W. S. S. Jee, S. Mori, X. J. Li, and S. Chan: Bone, 11, 253–266 (1990).

    Google Scholar 

  6. X. J. Li, W. S. S. Jee, and Y. L. Li: Bone, 10, 35 (1989).

    Article  Google Scholar 

  7. R. W. Norrdin, W. S.S. Jee, and W. B. High: Prostaglandins, Leukotrienes and Essential Fatty Acids, 41, 139–149 (1990).

    Article  Google Scholar 

  8. K. Klaushofer, O. Hoffman, E. Czerwenka, H. J. Leis, H. Gleispach, K. Koller, and M. Peterlik: J. Rheum., 5, 486 (1988).

    Google Scholar 

  9. T. M. El Attar, H. S. Liu, and D. E. Tira: J. Periodont. 55, 536 (1984).

    Google Scholar 

  10. J. H. Herman, A. M. Appel, R. C. Khosla, and E. V. Hess: J. Rheum., 16, 75 (1989).

    Google Scholar 

  11. R. J. Smith, D. G. Kaiser, P. L. Lomen, and K. D. Rainsford in: Anti-inflammatory and Antirheumatic Drugs, Vol. II, Boca Raton, Fl, CRC Press, p. 187(1985).

    Google Scholar 

  12. D. Crook, A. J. Collins, P. A. Brown, and R. Chan: Ann. Rheum. Dis., 35, 327 (1976).

    Google Scholar 

  13. R. C. Williams, M. K. Jeffcoat, M. L. Kaplan, A. Robert, P. Goldhaber, H. G. Johnson, and W. J. Wechter: Science, 227, 640 (1985).

    Article  Google Scholar 

  14. R. C. Williams, M. K. Jeffcoat, T. H. Howell, C. M. Hall, H. G. Johnson, W. J. Wechter, and P. Goldhaber: J. Periodont. Res., 22, 403 (1987).

    Article  Google Scholar 

  15. R. L. Smith and D. J. Shurman: The effect of NSAID therapy on the development of osteoporosis, an animal study. Personal communication, 1988.

    Google Scholar 

  16. R. C. Williams, M. K. Jeffcoat, and T. H. Howell: J. Periodont. Res., 23, 225 (1988).

    Google Scholar 

  17. a) M. K. Jeffcoat: J. Dent. Res., 68,999 [ABS 1055] (1989). (b) R. C. Williams, M. K. Jeffcoat, and T. H. Howell: J. Dent. Res., 68, 243 (1989).

    Google Scholar 

  18. R. C. Williams, M. K. Jeffcoat, and T. H. Howell: J. Periodont., 60, 485 (1989).

    Article  Google Scholar 

  19. N. Lane, D. B. Kimmel, and T. Cobie: Am Coll Rheum, Western Regional Meeting, Portland, March 22, 1990.

    Google Scholar 

  20. T. H. Howell, M. K. Jeffcoat, P. Goldhaber, M. S. Reddy, M. L. Kaplan, H. G. Johnson, C. M. Hall and R. C. Williams: J. Periodont. Res., 26, 498–501 (1991).

    Article  Google Scholar 

  21. M. K. Jeffcoat, R. C. Williams, W.J. Wechter, H. G. Johnson, and P. Goldhaber: J. Periodont. Res., 20, 532 (1985).

    Article  Google Scholar 

  22. a) T. Y. Shen: Angew. Chem. Int. Ed. Eng., 11, 460–472 (1972). (b) R. V. Thomlinson, H. J. Rinbold, M. C. Qurski, and E. Forchielli: Biochem. Biophys. Res. Comm., 46, 552–559 (1972).

    Google Scholar 

  23. a) W. J. Wechter, D. G. Loughhead, R. J. Reischer, D. G. Van Giessen, and D. G. Kaiser: Biochem. Biophys. Res. Comm., 61, 833 (1974). (b) W. J. Wechter, D. G. Loughhead, R. J. Reischer, D. G. Van Giessen, and D. G. Kaiser: Natl. Med. Chem. Symposium, 14, 19 (1974).

    Google Scholar 

  24. G. A. Higgs, K. E. Eakins, K. G. Mugridge, S. Moncada, and J. Vane: J. Europ. Pharm., 66, 81 (1980).

    Article  Google Scholar 

  25. G. Vaes: Clin. Orth, and Rel. Res., 231, 239–271 (1988).

    Google Scholar 

  26. T. J. Chambers in: Ciba Foundation Symposium No. 136, Cell and Molec-ular Biology of Vertebrate Hard Tissue, New York, John Wiley & Sons, pp. 92–107(1988).

    Google Scholar 

  27. B. E. Barton and R. Mayer: J. Immunol., 143, 3211–3216 (1989).

    Google Scholar 

  28. Y. Ishimi, C. Majawa, C. D. Jim, A. Tisuhiko, E. Abe, Y. Nakamura, A. Yamaguchi, S. Yoshiki, T. Matsuda, T. Hirano, T. Kishimoto, and T. Suda: J. Immunol., 145, 3297–3303 (1990).

    Google Scholar 

  29. S. Doppelt, A. Augustine, and H. J. Mankin: Orthopedic Res. Soc. Annual Meeting Abstract (1987).

    Google Scholar 

  30. R. C. Williams, S. Offenbacher, M. K. Jeffcoat, T. H. Howell, C. M. Hall, H. G. Johnson, W. J. Wechter, and P. Goldhaber: J. Periodont. Res., 23, 134 (1988).

    Google Scholar 

  31. R. Hirschelmann, S. Zarnock, T. Funke, K. Schmidt, H. Bekemeier, S. Geissler, and H. Ulbright: Biomed. Biochem., 47, S-318 (1988).

    Google Scholar 

  32. Y. Ishihara, E. Mari. T. Wishihara, T. Noguchi, and T. Koga: J. Periodont. Res., 26, 155–160 (1991).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Chemical Endocrinology, Department of Medicine, Loma Linda University Medical Center, Loma Linda, California, 92350, USA

    William J. Wechter

Authors
  1. William J. Wechter
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Basel, Switzerland

    Ernst Jucker

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Birkhäuser Verlag Basel

About this chapter

Cite this chapter

Wechter, W.J. (1992). The effects of NSAIDs and E-prostaglandins on bone: A two signal hypothesis for the maintenance of skeletal bone. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 39. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7144-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-7144-0_10

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7146-4

  • Online ISBN: 978-3-0348-7144-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation