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Drugs affecting serotonin neurons

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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

Part of the book series: Progress in Drug Research ((PDR,volume 35))

Abstract

Most of the currently identified neurons that make and release serotonin as their neurotransmitter are in the central nervous system (CNS), and those will be the focus in this chapter. Serotonin in the gastrointestinal tract is mainly in enterochromaffin cells of the mucosal epithelium, but there are serotonin neurons in the enteric nervous system [1]. Serotonin neurons in the CNS have their cell bodies mainly clustered along the midline (raphe areas) of the midbrain and brain stem, and they send widespread projections to many regions of the forebrain as well as downward to the spinal cord. Their projection to many parts of the CNS involved in many different physiologic functions [2, 3] allows serotonin neurons to influence many brain functions, and they may play some part in the pathologic state in diverse diseases. Also, drugs that modify the function of serotonin neurons have various therapeutic uses or potential therapeutic uses as well as being valuable pharmacologic tools in helping to understand physiologic roles of serotonin neurons.

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    Ray W. Fuller

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Fuller, R.W. (1990). Drugs affecting serotonin neurons. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research, vol 35. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7133-4_3

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