Abstract
The word drug in this review has been used in line with the classical concept, i. e., a substance possessing a pharmacological effect particularly on the mammalian organism. It is only through a planned and careful evaluation of this effect during years of preclinical and successful clinical studies that the effective substance finally becomes a therapeutically useful drug.
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References
B. W. Halstead: Poisonous and Venomous Marine Animals of the World, vol. 1. US GPO, Washington, DC 1965. pp. 1–29.
G.A. Emerson and C. H. Taft: Toxicol. Rep. Biol. Med. 3, 302 (1945).
R. F. Nigrelli: Biochemistry and Pharmacology of Compounds Derived from Marine Organisms, Ann. NY Acad. Sci., New York 1960.
H.C. Freudentahl: Drugs From the Sea, Marine Technol. Soc., Washington, DC 1968.
A. Der Marderosian: J. Pharm. Sci. 58, 1 (1969).
M.H. Baslow: Marine pharmaceuticals, Williams & Wilkins, Baltimore 1969.
H. W. Youngken: Food Drugs from the Sea Proceedings, Marine Technol. Soc., Washington, DC 1969.
F. E. Russel: International Encyclopedia of Pharmacology and Therapeutics 2, 3 (1971).
L. R. Worthen: Food Drugs from the Sea Proceedings, Marine Technol. Soc., Washington, DC 1972.
D. Martin and G. Padilla: Marine Pharmacognosy, Academic, New York 1973.
H. H. Webber and G. D. Ruggieri: Food Drugs from the Sea Proceedings, Marine Technol. Soc., Washington, DC 1976.
G. D. Ruggieri: Science 194, 491 (1976).
Y. Hashimoto: Marine Toxins and Other Bioactive Marine Metabolites, Japan Sci., Tokyo 1979.
P. N. Kaul and C.J. Sindermann: Drugs and Food from the Sea — Myth or Realitiy? Oklahoma Univ. Printing, Norman 1978.
P. N. Kaul: Impact Sci. on Soc. 29, 123 (1979).
P. N. Kaul: Fed. Proc. 40,10 (1981).
P. N. Kaul: Pure Appl. Chem. 54, 1963 (1982).
M. Chr. Krebs: Fortschr. Chem. Organ. Naturstoffe 48, 151 (1986).
D.J. Faulkner: Nat. Prod. Rep. 1, 251 and 551 (1984); 3, 1 (1986); 4, 539 (1986); 5, 613 (1988).
P. N. Kaul and P. Daftari: Ann. Rev. Pharmacol. Toxicol. 26, 117 (1986).
Y. Ogura: Eur. J. Pharmacol. 3, 58 (1968).
A. J. Weinheimer, J. A. Matson, T. K. B. Karns, M. B. Hossain and D. van der Helm: pp. 117–21 in Ref. 14.
Y. Kashman, A. Groweiss, S. Carmely, Z. Kinamoni and D. Czarkie: Pure Appl. Chem. 54, 1995 (1982).
B. Tursch, J.C. Braekman, D. Caloze and M. Kaisin: Marine Natural Products, vol 2. Academic, New York/London 1978. pp. 247–96.
M. G. Hadfield and L. S. Ciereszko: pp. 145–50 in Ref. 14.
P. N. Kaul: pp. 209–307 in Ref. 9.
D. L. Perkins and L. S. Ciereszko: Hydrobiologia 42, 77 (1973).
Y. Kobayashi and K. Osabe: Chem. Pharm. Bull. 37, 631 (1989).
G. R. Pettit, C.L. Herald, D. L. Doubej and D. L. Herald: J. Am. Chem. Soc. 104, 6846 (1982).
I. L. Dale, T. D. Bradshaw, A. Gescher and G. R. Pettit: Cancer Res. 49, 3242 (1989).
H.G. Drexler, S.M. Gignac, R. A. Jones, C.S. Scott, G.R. Pettit and V. Hoffbrand: Blood 74, 1747 (1989).
W. S. May, S. T. Sharkis, E. H. Ahmed, V. Gebbia, A. S. Kraft and G. R. Pettit: Proc. Natl. Acad. Sci. (USA) 84, 8483 (1987).
K. L. Rinehart, J.B. Gloer, G. R. Wilson, R.G. Hughes and H. L. Li: Fed Proc. 42, 87 (1983).
H.G. Chun. B. Davies, D. Hoth, M. Suffness, J. Plowman, K. Flora, C. Grieshaber and L. Jones: Invest. New Drugs, 4, 279 (1986).
K. L. Rinehart, V. Kishore, K. C. Bible, R. Saki, D. W. Sullivan and K. M. Li: J. Nat. Prod. 51, 1 (1988).
W. Lichter, L. L. Wellham, B. A. van der Werf, R. E. Middlebrook and M. M. Sigel: pp. 117–27 in Ref. 9.
W. Lichter. A. Ghaffar, L. L. Wellham and M. M. Sigel: pp. 137–44 in Ref. 14.
M. M. Sigel, W. Lichter, A. Ghaffar, L. L. Wellham and A.J. Weinheimer: Adv. Exp. Med, Biol. a. 121, 577 (1979).
W. C. Dunn, W. L. Carrier and J. D. Regan: Toxicon 20, 703 (1982).
K. L. Rinehart: Pure Appl. Chem. 61, 525 (1989).
B.M. Degnan, C.J. Hawkins, M.F. Layon, E.J. McCaffrey, D. L. Parr and D.J. Walters: J. Med. Chem. 32, 1354 (1989).
B.M. Degnan, C.J. Hawkins, M.F. Lavin, E.J. McCaffrey, D. L. Parry, A. L. van der Brenk and D.J. Walters: J. Med. Chem. 32, 1349 (1989).
R. E. Moore, S. Banerjee, V. Bornemann, F. R. Caplan, J. L. Chen. D.C. Corley, L. K. Larsen, B.S. Moore, G. M. L. Patterson, V.J. Paul, J.B. Stewart and D. E. Williams: Pure App. Chem. 61, 521 (1989).
G. R. Pettit, Y. Kamano, C. L. Herald, C. Dufresne, R. L. Cerny, D. L. Herald, J. M. Schmidt and H. Kizu: J. Amer. Chem. Soc. 111, 5015 (1989).
N. S. Burres and J.J. Clement: Cancer Res. 49, 2935 (1989).
G. Cimino, S. DeRosa and S. De Stefano: Experientia 40,339 (1984).
E. T. O’Brien, R. S. Jacobs and L. Wilson: Mol. Pharmacol. 24, 26 (1983).
E.T. O’Brien, D.J. Asai, R.S. Jacobs and L. Wilson: Mol. Pharmacol. 35, 635 (1989).
K. Iguchi, S. Saitoh and Y. Yameda: Chem. Pharm. Bull. 37, 2553 (1989).
I. Kitagawa, M. Kobayashi, N. K. Lee, Y. Oyama and Y. Kyogoku: Chem. Pharm. Bull. 37, 2078 (1989).
Y. Hirata: Pure Appl. Chem. 61, 293 (1989).
P. S. Sarin, D. Sun, A. Thornton and W. E.G. Miller: J. Natl. Cancer Inst., 78,663 (1987).
T. R. Norton, S. Shibata, M. Kashigawa and J. Bentley: J. Pharm. Sci. 65, 1368 (1976).
S. Shibata, T. I. Zumi, T. Matsuo and S. Katsuki: J. Pharmacol. Exp. Ther. 199, 298 (1976).
S. Shibata, T. I. Zumi, D.G. Seriguchi and T. R. Norton: J. Pharmacol. Exp. Ther. 205, 683 (1978).
A. Scriabine, C. G. van Arman, G. Morgan, A. A. Morris, C. D. Bennett and N. R. Bohidar: J. Cardiovasc. Pharmacol. 1, 571 (1979).
I. Kodama, J. Toyama, S. Shibata and T. R. Norton: J. Cardiovasc. Pharmacol. 3, 75 (1981).
G.J. Gross, D.C. Warltier, M. F. Hardman and S. Shibata: Eur. J. Pharma-col. 110, 271 (1985).
L. Beress: pp. 59–72 in Ref. 14.
R. Alsen, T. Peters and E. Scheufler: J. Cardiovasc. Pharmacol. 4, 63 (1982).
J. Barhanin, M. Hughes, H. Scheweitz, J. P. Vincent and M. Lazdunski: Toxicon 20, 59 (1982).
A. A. Nabiullin, S. E. Odinikov, E. P. Kozlovskaya and G.B. Elyakov: FEBS Lett. 141, 124 (1982).
T. R. Norton: Fed. Proc. 40, 21 (1981).
B. A. Gorshkov, V. A. Stonik and G. B. Elyakov: Toxicon 20, 655 (1982).
D. Graff and C.J. P. Grimmelikhuijzen: Brain Research 4442, 354 (1988).
R. S. Norotn, G. Bobek, J. O. Ivanov, M. Thompson, E. Fiala-Beer, R. L. Moritz and R. J. Simpson: Toxicon 28, 29 (1990).
S.S. Cohen: Cancer 40, 509 (1977).
F. A. Fuhrman, G. J. Fuhrman, Y. H. Kim, L. A. Pavelka and H. S. Mosher: Science 207, 193 (1980).
L. P. Davis, D. D. Jamieson, J.A. Baird-Lambert and R. Kazlauskas: Biochem. Pharmacol. 33, 347 (1984).
K. Laderis and K. L. MacCannell: pp. 51–59 in Ref. 14.
K. Laderis, A. Letter, D. McMaster, G. Moore and D. Schlesinger: Science 218, 162 (1982).
D. McMaster and K. Laderis: Peptides 4, 367 (1983).
K. Owada, M. Kawata, L. Akagi, A. Takagi, M. Moriga and H. Kobyashi: Cell Tissue Res. 239, 349 (1985).
W. M. Lafranconi, I. Ferlan, F. E. Russell and R.J. Huxtable: Toxicon 22, 347 (1984).
J. P. Girard, C. Marion, M. Liutkus, M. Boucard, E. Recheneq, J. P. Vidal and J. C. Rossi: Planta Medica 54, 193 (1988).
H. A. Hoppe and T. Levring: Marine Algae in Pharmaceutical Sciences. vol. 2. de Gruyter, Berlin 1982.
J. Kobayashi, Y. Ohizumi, H. Nakamura, Y. Hirata, W. Wakamatsu and T. Miyazawa: Experientia 42, 1064 (1986).
K.H. Hollenbeak, F.J. Schmitz, P. N. Kaul and S. K. Kulkarni: pp. 81–87 in Ref. 14.
R. J. P. Cannell, S.J. Kellam, A.M. Owsianka and J.M. Walker: J. Gen. Microbiol. 133, 1701 (1987).
H. Nakashima, Y. Kido, N. Kobayashi, Y. Motoki, M. Neeshul and N. Yamamoto: J. Cancer Res. Clin. Oncol. 113, 413 (1987).
N. Fusetani, M. Sugano, S. Matsunaga, K. Hashimoto, H. Shikama, A. Ohta and N Nagano: Experientia 43, 1233 (1987).
N. Fusetani, M. Sugano, S. Matsunaga and K. Hashimoto: Experientia 43, 1234 (1987).
E. D. De Siva and P. J. Scheuer: Tetrahedron Lett. 21, 1611 (1980).
K.B. Glaser and R. S. Jacobs: Biochem. Pharmacol. 35, 449 (1986); 36, 2079 (1987).
L. A. Wheeler, G. Sachs, G. DeVries, D. Goodrum, E. Woldemussie and S. Muallem: J. Biol. Chem. 262, 6531 (1989).
P.J. Scheuer: Chemistry of Marine Natural Products. Academic, New York 1973.
J. Baker and V. Murphy: Handbook of Marine Sciences. CRC, Cleveland 1976.
F.J. Schmitz, Y. Gopichand, D. Michaud, R. S. Prasad and S. Ramaley: Pure Appl. Chem. 103, 2469 (1981).
K. Tachibana, P.J. Scheuer, Y. Tsukitani, H. Kiruchi and D. van Engen: J. Am. Chem. Soc. 103, 2469 (1981).
S. Shibata, Y. Ishida, H. Kitano, Y. Ohizumi and J. Habon: J. Pharmacol. Exp. Ther. 223, 135 (1982).
M. Isobe, Y. Ichikawa and T. Goto: Tetrahedron Lett. 27, 963 (1986).
D. Uemura, K. Takahashi, T. Yamamoto, C. Katayama, J. Tanaka, Y. Okumura and Y. Hirata: J. Am. Chem. Soc. 107, 4796 (1985).
Y. Hirata and D. Uemura: Pure Appl. Chem. 58, 201 (1986).
D. W. Cameron, G. I. Fentrill, C. L. Gibson and R. W. Reed: Tetrahedron Lett. 26, 3887 (1985).
Y. Okami: Microb. Ecol. 12, 65 (1986).
Y. Kashman, A. Groweiss and U. Shmueli: Tetrahedron Lett. 21, 3629 (1980).
A. Groweiss, U. Shmueli and Y. Kashman: J. Org. Chem. 48, 3512 (1983).
Y. Kashman, A. Groweiss, R. Lidor, D. Blasberger and S. Carmely: Tetrahedron 41, 1905 (1985).
I. Spector, R. R. Schochet, Y. Kashman and A. Groweiss: Science 219, 493 (1983).
N. B. Perry, J. W. Blunt, J.D. McCombsand, M.H.G. Munro: J. Org. Chem. 51, 5476 (1986).
J. Kobayashi, J. F. Cheng, M. Ishibashi, H. Nakamura, Y. Ohizumi. Y. Hi- rata, T. Sasaki, H. Lu and J. Clardy: Tetrahedron Lett. 28, 4939 (1987).
E. Fattorusso, V. Lanzotti, S. Magno and E. Novellino: J. Nat. Prod. 48, 924 (1985).
G. Lindgren, L. Bohlin and J. Bergman: Tetrahedron Lett. 27, 3283 (1986).
T.M. Zabriskie, J. A. Klocke, C. M. Ireland, A. H. Marcus, T. F. Molinski, D. J. Faulkner, C. F. Xu and J. Clardy: J. Am. Chem. Soc. 108, 3123 (1986).
R. Piccoli, D. Melek, A. Spagnuolo, S. Vescia and L. Zanetti: Comp. Biochem. Physiol. 80C, 237 (1983).
D. V. Rao, V. S. N. Raju, B. W. Sullivan and D. J. Faulkner: Heterocycles 28, 103 (1989).
D. H. Attaway and L.S. Ciereszko: Proc. Soc. Int. Coral Reef Sym. 7, 497 (1974).
R. E. Moore and P. J. Scheuer: Science 172, 495 (1971).
P. N. Kaul: Proc. West. Pharmacol. Soc. 17, 294 (1974).
P. N. Kaul: p. 311 in Ref. 11.
R. E. Moore and G. Bartolini: J. Am. Chem. Soc. 103, 2491 (1981).
J. K. Cha, W.J. Christ, J. M. Finin, M. Fujioka, Y. Kishi, L. L. Klein, S.S. Ko, J. Leder, W. W. McWhorter, K. P. Pfaff, M. Yonaga, D. Uemura and Y. Hirata: J. Am. Chem. Soc. 104, 7369 (1982).
R. W. Armstrong, J. M. Beau, S. M. Cheon, W.J. Christ, M. Fujioka, W. M. Ham, L. D. Hawkins, H. Jin, S. H. Kang, Y. Kishi, M.J. Martinelli, W.C. McWhorther, M. Mizuno, M. Nakato, A. E. Stutz, F. X. Talamas, M. Taniguchi, J.A. Tino, K. Ueda, J. I. Uenishi, J. B. White and M. Yonaga: J. Am. Chem. Soc. 111, 7525 (1989); 111, 7530 (1989).
Y. Kishi: Pure Appt Chem. 61, 313(1989).
S. K. Kulkarni, W. G. Kirlin and P. N. Kaul: pp. 73–80 in Ref. 14.
E. Habermann: Toxicon 27, 1171 (1989).
A. M. Kodama, Y. Hokama, T. Yashimota, M. Fukni, S.J. Manea and N., Sutherland: Toxicon 27, 1051 (1989).
M. D. Rayner, B. J. Sanders, S. M. Harris, Y. C. Lin and B. E. Morton: Res. Commun. Chem. Path. Pharmacol. 11, 55 (1975).
K. Ito, H. Karaki and N. Urakawa: Eur. J. Pharmacol. 46, 9 (1979).
M. Tatsumi, M. Takahashi and Y. Ohizumi: Molec. Pharmacol. 25, 379 (1984).
Y. Ishida, N. Satake, J. Habon, H. Kitano and S. Shibata: J. Pharmacol. Exp. Ther. 232, 551 (1985).
H. Ozaki, H. Nagase, H. Karaki and N. Urakawa: Comp. Biochem. Physiol. 86C, 387 (1987).
E. Habermann and M. Lanx: Naunyn-Schmiedeberg’s Arch. Pharmacol. 334, 1 (1986).
L. Levine and H. Frijika: Carcinogenesis 6, 1631 (1985).
H. Nagasi and H. Karaki: J. Pharamcol. Exp. Ther. 242, 1120 (1987).
Y. Ishida, A. Kajiwara, K. Takagi, Y. Ohizumi, and S. Shibata: J. Pharma-col. Exp. Ther. 232, 551 (1985).
G.S. Chhatwaal, G. Ahnert-Hilger, L. Beress and E. Habermann: Intro. Arch. Allergy Appt Immun. 68, 97 (1982).
E. Habermann, G. Ahnert-Hilger, G. S. Chhatwaal and L. Beress: Biochem. Biophys. Acta. 649, 481 (1981).
T.J. Starr: Texas Rep. Biol. Med. 16, 813 (1958).
K. Hashimoto and K. Noguchi: Pure Appl. Chem. 61, 7 (1989).
T. Narahashi: Physiol. Rev. 54, 813 (1974).
C.Y. Kao: Red. Proc. 40, 30 (1981).
Y. Schmizu: Pure Appl. Chem. 54, 1973 (1982).
M.A. Poli, Ti. Mende and G. Baden: Mol. Pharmacol. 30, 129 (1986).
K. Nakanishi: Toxicon 23, 473 (1985).
R. L. Rodgers, H.N. Chou, K. Temma, T. Akera and Y. Shimizu: Toxicol. Appl. Pharmacol. 76, 296 (1984).
J. M. C. Huang, C. H. Wu and D.G. Baden: J. Pharmacol. Exp. Ther. 229, 615 (1984).
D.G. Baden, G. Bikenazi, S. Decker, F. F. Foldes and I. Leung: Toxicon 22, 75 (1984).
D.G. Baden, T.J. Mende, J. Walling and R. Schultz: Toxicon 22, 783 (1984).
D.G. Baden: FASEB J. 3, 1807 (1989).
P.J. Scheuer, W. Takanashi, J. Tsutsumi and T. Yoshida: Science 155, 1267 (1967).
R. Adachi and T. Fukuyo: Bull. Jpn. Soc. Sci. Fish. 45, 67 (1979).
R. W. Dickey, D.M. Miller and D.R. Tindell: ACS Symposium Series 262, 257 (1984).
M. Takahashi, M. Tatsumi and Y. Ohizumi: J. Biol. Chem. 258, 10944 (1983).
T. Miyamoto, Y. Ohizumi, H. Washio and Y. Yasumoto: Pfluegers Arch. 400, 439 (1984).
S. B. Freedman, R.J. Miller, D. M. Miller and D. R. Tindal: Proc. Natl. Acad. Sci. USA 81, 4582 (1984).
M. Kobayashi, G. Miyakado, T. Nakamura and Y. Ohizumi: Eur. J. Pharmacol. 111, 121 (1985).
I. A. Shalaby, S. Kongsamut and R.J. Miller: J. Neurochem. 46, 1161 (1986).
J. D. Veldhuis, K. Yoshida, W. DuBois and M.J. Fields: Amer. J. Physiol. 252E, 8 (1987).
M. Kobayashi, R. Ochi and Y. Ohizumi: Br. J. Pharmacol. 92, 665 (1987).
G. Santostasi, R. Kutty, A. L. Bartorelli, T. Yasumota and G. Krishna: Toxicol. Appl. Pharmacol. 102, 164 (1990).
A. Yokoyama, M. Mureta, Y. Oshima, T. Iwashita and T. Yasumoto: J. Biochem. 104, 184 (1988).
M. Nukina, L. M. Koyanagi and P.J. Scheuer: Toxicon 22, 169 (1984).
A. M. Legrand, M. Galonnier and R. Bagnis: Toxicon 20, 311 (1982).
A. M. Legrand and R. Bagnis: Toxicon 22, 471 (1984).
J. N. Bidard, H.P. M. Vijverberg, C. Frelin, E. Chungue, A. M. Legrand, R. Bagnis and M. Lazdunski: J. Biol. Chem. 259, 8353 (1984).
A. Seino, M. Kobayashi, K. Momose, T. Yasumoto and Y. Ohizumi: Br. J. Pharmacol. 95, 876 (1988).
L.J. Cruz, W.R. Gray, B.M. Olivera, R.D. Zeikus, L. Kerr, D. Yoshikami and F. Moczyllowski: J. Biol. Chem. 260, 9280 (1985).
M. Kobayashi, C. H. W, M. Yoshii, T. Narahashi, H. Nakamura, J. Kobayashi and Y. Ohizumi: Pflugers Arch. 407, 241 (1986).
S. Sato, H. Nakamura, Y. Ohizumi, J. Kobayashi and Y. Hirata: FEBS Lett. 155, 277 (1983).
Y. Yanagawa, T. Abe and M. Satake: J. Neurosci. 7, 1498 (1987).
B. M. Olivera, J. M. McIntosh, R. Zeikus, W. R. Gray, J. Verga, J. Rivier, V. de Santos and L. J. Cruz: Science 230, 1338 (1985).
L. M. Kerr and D. Yoshikami: Nature 308, 282 (1984).
D.H. Feldman, B. M. Olivera and D. Yoshikami: FEBS Lett. 214, 295 (1987).
R. E. Yeager, D. Yoshikami, J. Rivier, L.J. Cruz and G. P. Miljanich: J. Neurosci. 7, 2390 (1987).
L. J. Cruz and B. M. Olivera: J. Biol. Chem. 261, 6230 (1986).
T. Gonoi, Y. Ohizumi, J. Kobayashi, H. Nakamura and W.A. Catterall: Mol. Pharmacol. 32, 691 (1987).
J. Kobayashi, H. Nakamura, Y. Hirata and Y. Ohizumi: Toxicon 20, 823 (1982).
Y. Ohizumi, M. Kobayashi, A. Muroyama, H. Nakamura and J. Kobayashi: Br. J. Pharmacol. 95, 876 (1988).
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Kaul, P.N. (1990). Drug molecules of marine origin. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research, vol 35. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7133-4_10
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