Abstract
In 1974, I published [1] an analysis of the structure-activity relationships of convulsant drugs in terms of their relationships to model receptors for GABA and glycine. However, this early model did not distinguish between drugs acting at the amino acid receptors and those acting at the ionophores these receptors control. This present analysis therefore seeks to add this extra dimension. My method is to examine a wide range of compounds acting at a particular site in terms of their molecular structure as revealed by CPK models, and then to attempt to deduce the simplest protein structure that is complementary to all these drugs, agonists as well as antagonists. The problem is akin to designing one common lock that may be turned by a variety of keys (see e.g. [2]).
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Smythies, J.R. (1980). Relationships between structure and function of convulsant drugs. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 24. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7108-2_2
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DOI: https://doi.org/10.1007/978-3-0348-7108-2_2
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