In 1974, I published [1] an analysis of the structure-activity relationships of convulsant drugs in terms of their relationships to model receptors for GABA and glycine. However, this early model did not distinguish between drugs acting at the amino acid receptors and those acting at the ionophores these receptors control. This present analysis therefore seeks to add this extra dimension. My method is to examine a wide range of compounds acting at a particular site in terms of their molecular structure as revealed by CPK models, and then to attempt to deduce the simplest protein structure that is complementary to all these drugs, agonists as well as antagonists. The problem is akin to designing one common lock that may be turned by a variety of keys (see e.g. [2]).


Gaba Receptor Lower Tier Gaba Antagonist Nipecotic Acid Hydrogen Bonding Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Birkhäuser Verlag Basel 1980

Authors and Affiliations

  1. 1.Neurosciences Program and Department of PsychiatryThe University of Alabama in BirminghamBirminghamUSA

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