Skip to main content
SpringerLink
Log in

Adverse reactions of sugar polymers in animals and man

  • Chapter
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

  • 121 Accesses

Abstract

The most commonly-used fluids as vehicles for intravenous injections into man are 5% (w/v) dextran and normal saline, fluids used to increase the volume of circulating blood in shock and haemorrhagic states as well as to counteract dehydration. Yet reports appear each year in the literature to show that adverse reactions occur either through contamination or as a result of the presence of impurities. For example, an equimolecular mixture of glucose and fructose, derived from sucrose and called invert sugar, has recently been found [35] to produce adverse reactions on intravenous injection into some patients and these reactions have resulted from the presence of minute quantities of impurities and not from microbial contamination. Hydrolyzed sucrose (that is, invert sugar) is sterilized by autoclaving or by filtration and such solutions are used in the treatment of varicose veins and other vascular disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. V. W. Adamkiewicz and I. M. Adamkiewicz: Am, J. Physiol. 198, 51 (1960).

    Google Scholar 

  2. V. W. Adamkiewicz and Y. Langlois: Can. J. Biochem. 35, 251 (1957).

    Google Scholar 

  3. R.E. Anderson, T.H.P. Hanahoe and G.B. West: Int. Arch. Allergy appl. Immun. 50, 301 (1978).

    Article  Google Scholar 

  4. R.E. Anderson, P.J. Warne and G.B. West: Int. Arch. Allergy appl. Immun. 52, 425 (1976).

    Article  Google Scholar 

  5. S.I. Ankier, M.S. Starr and G.B. West: Int. Arch. Allergy appl. Immun. 32, 329(1967).

    Article  Google Scholar 

  6. S. I. Ankier and G. B. West: Br. J. Pharmac. 33, 304 (1968).

    Google Scholar 

  7. J. Badcock, T.H.P. Hanahoe and G.B. West: Agents and Actions 4, 199 (1974).

    Article  Google Scholar 

  8. I. Cottney and A. J. Lewis: Br. J. Pharmac. 53, 445P (1975).

    Google Scholar 

  9. A.K. Delitheos, T.H.P. Hanahoe and G.B. West: Int. Arch. Allergy appl. Immun. 50, 436(1976).

    Article  Google Scholar 

  10. H. L. Dhar, T. H. P. Hanahoe and G. B. West: Int. Arch. Allergy appl. Immun. 57, 637 (1976).

    Article  Google Scholar 

  11. M. Di Rosa and D. A. Willoughby: J. Pharm. Pharmac. 23, 297 (1971).

    Article  Google Scholar 

  12. V. Eisen, P. C. Freeman, C. Loveday and G. B. West: Br. J. Pharmac. 49, 688 (1973).

    Google Scholar 

  13. J.C. Foreman, L.G. Garland and J. L. Mongar: 30th Symp. Soc. for Experimental Biology, p. 193. Cambridge University Press, Cambridge 1976.

    Google Scholar 

  14. J. C. Foreman and J. L. Mongar: Br. J. Pharmac. 46, 767 (1972).

    Google Scholar 

  15. P. C. Freeman and G. B. West: Br. J. Pharmac. 44, 327 P (1972).

    Google Scholar 

  16. A. Goth: Fed. Proc. Fed. Am. Soc. exp. Biol. 20, 257 (1961).

    Google Scholar 

  17. A. Goth: Mechanism of release of biogenic amines, p. 371. Pergamon Press, Oxford 1966.

    Google Scholar 

  18. A. Goth, H. R. Adams and M. Knoohuizen: Science, N.Y. 173, 1034 (1971).

    Article  Google Scholar 

  19. A. Goth, W.L. Nash, M. Nagler and J. Holman: Am. J. Physiol. 191, 25 (1957).

    Google Scholar 

  20. T. H. P. Hanahoe, W. Paska and G. B. West: Monographs in Allergy, in press (1979).

    Google Scholar 

  21. T.H.P. Hanahoe, T. Tanner and G.B. West: J. Pharm. Pharmac. 25, 429 (1973).

    Article  Google Scholar 

  22. D. Harper and G. B. West: Int. Arch. Allergy appl. Immun. 52, 407 (1976).

    Article  Google Scholar 

  23. J. M. Harris, H. Kalmus and G. B. West: Genet. Res. Camb. 4, 346 (1963).

    Article  Google Scholar 

  24. J. M. Harris, D. K. Luscombe and R. H. Poyser: Br. J. Pharmac. 29, 16 (1967).

    Google Scholar 

  25. J. M. Harris and G. B. West: Br. J. Pharmac. 20, 550 (1963).

    Google Scholar 

  26. E.A. Rabat, G.M. Turino, A.B. Tarrow and P.H. Maurer: J. clin. Invest. 36, 1160(1957).

    Article  Google Scholar 

  27. M. Koltai, G. Blazso, E. Minker, I. Lonovics and A. Ottlecz: Int. Arch. Allergy appl. Immun. 49, 358 (1975).

    Article  Google Scholar 

  28. M. Koltai, A. Ottlecz, E. Minker and G. Blazso: Int. Arch. Allergy appl. Immun. 46, 261 (1974).

    Article  Google Scholar 

  29. J. Leger and G. M. C. Masson: Ann. Allergy 6, 131 (1948).

    Google Scholar 

  30. A. Ottlecz, M. Koltai and E. Dekov: Int. Arch. Allergy appl. Immun. 50, 548 (1976).

    Article  Google Scholar 

  31. J. R. Parratt and G. B. West: J. Physiol., Lond. 139, 27 (1957).

    Google Scholar 

  32. J. R. Parratt and G. B. West: Int. Arch. Allergy appl. Immun. 16, 288 (1960).

    Article  Google Scholar 

  33. R. H. Poyser and G. B. West: Br. J. Pharmac. 25, 602 (1965).

    Google Scholar 

  34. R.H. Poyser and G.B. West: Br. J. Pharmac. 32, 219 (1968).

    Google Scholar 

  35. A.W. Richter, K. Granath and G. Ostling: Int. Arch. Allergy appl. Immun. 50, 606 (1976).

    Article  Google Scholar 

  36. R. K. Sanyal, P. S. J. Spencer and G. B. West: Nature, Lond. 184, 2020 (1959).

    Article  Google Scholar 

  37. H. Selye: Endocrinology 21, 169 (1937).

    Article  Google Scholar 

  38. P.S.J. Spencer and G.B. West: Int. Arch. Allergy appl. Immun. 20, 321 (1962).

    Article  Google Scholar 

  39. M. S. Starr and G. B. West: Prog. Drug Res. 14, 196 (1970).

    Google Scholar 

  40. G. Thomas and G. B. West: Br. J. Pharmac. 47, 662 P (1973).

    Google Scholar 

  41. G. Thomas and G. B. West: J. Pharm. Pharmac. 25, 753 (1973).

    Article  Google Scholar 

  42. T. Uryu and C. Schuerch: Macromolecules 4, 342 (1971).

    Article  Google Scholar 

  43. B. Uvnas and I.L. Thon: Mechanism of release of biogenic amines, p. 361. Pergamon Press, Oxford 1966.

    Google Scholar 

  44. A.B. Voorhees, H.J. Baker and E.J. Pulaski: Proc. Soc. exp. Biol. Med. 76, 254 (1951).

    Google Scholar 

  45. G. B. West: Int. Arch. Allergy appl. Immun. 47, 296 (1974).

    Article  Google Scholar 

  46. G. B. West: Int. Arch. Allergy appl. Immun. 49, 217 (1975).

    Article  Google Scholar 

  47. G. B. West: Int. Arch. Allergy appl. Immun. 55, 542 (1977).

    Article  Google Scholar 

  48. G. B. West: Int. Arch. Allergy appl. Immun. 56, 155 (1978).

    Article  Google Scholar 

  49. G. B. West: Int. Arch. Allergy appl. Immun. 56, 380 (1978).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Paramedical Sciences, North-East London Polytechnic, London, UK

    G. B. West

Authors
  1. G. B. West
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Basel, Switzerland

    Ernst Jucker

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Birkhäuser Verlag Basel

About this chapter

Cite this chapter

West, G.B. (1979). Adverse reactions of sugar polymers in animals and man. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 23. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7105-1_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-7105-1_2

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7107-5

  • Online ISBN: 978-3-0348-7105-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation