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Fundamental Structures in Drug Research

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Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques

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Abstract

One of the many difficulties the pharmaceutical chemist has to contend with is to organize the multitude of drugs now in existence into some sort of personal classification system that will enable him to pursue his own research methodically and purposively.

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References

  1. Wheeler, in: Medicinal Chemistry, Vol.6 (Eds. E.E. Campaigne and W.H. Härtung; Wiley, New York 1963); M.W. Johns, Drugs 9, 448 (1975); B. Davis, Adv. Drug Res. 10, 1 (1975).

    Google Scholar 

  2. Modern Inhalation Anesthetics, Handb. exp. Pharm. 30 ( M.B. Chenoweth; Springer, Berlin 1972 ).

    Google Scholar 

  3. R.M. Featherstone and C.A. Muehlbacher, Pharm. Rev. 15, 97 (1963); K.W. Miller, W.D.M. Paton, E.B. Smith and R.A. Smith, Anesthesiology 36, 339 (1972); L. J. Mullins, Chem. Rev. 54, 289 (1954).

    Google Scholar 

  4. O. Liebreich, Berl. klin. Wschr. 1869, 325.

    Google Scholar 

  5. E. Fischer and J. Mering, Ther. Gegenw. 1903, 97.

    Google Scholar 

  6. W.J. Doran, in: Medicinal Chemistry, Vol. 4 (Eds. F.F. Blicke and R.H. Cox; Wiley, New York 1959 ), p. 1.

    Google Scholar 

  7. C. D. Richards, J. Physiol. 227, 749 (1972).

    Google Scholar 

  8. S. S. Brown and S. Goenechea, Clin. Pharmac. Ther. 14, 314 (1973).

    Google Scholar 

  9. Psychopharmacological Agents, in: Medicinal Chemistry (Ed. G. deStevens), Vols. 4–1 to 4–III (Ed. M. Gordon; Academic Press, New York 1964, 1967, 1974 ).

    Google Scholar 

  10. H. Laborit and P. Huguenard, Presse méd. 59, 1329 (1951); H. Laborit, P. Higuenard and R. Alluaume, Presse méd. 60, 206 (1952).

    Google Scholar 

  11. J. Delay and P. Deniker, Congr. des Médecins Aliénistes et Neurologistes de France et des Pays de Langue Franç., Luxembourg 1952 (Ed. P. Cossa; Masson, Paris 1952 ), p. 503.

    Google Scholar 

  12. Phenothiazines and Structurally Related Drugs, Adv. Biochem. Psychopharm. 9 (Eds. I.S. Forrest, C.J. Carr and E. Usdin; Raven Press, New York 1974); E. Schenker and H. Herbst, Prog. Drug Res. 5, 269 (1963).

    Google Scholar 

  13. M.H.J. Koch, Molec. Pharmac. 10, 425 (1974).

    Google Scholar 

  14. A. P. Feinberg and S.H. Snyder, Proc. nat. Acad. Sci. USA 72, 1899 (1975); P. Seeman, M. Chau-Wong, J. Tedesco and K. Wong, ibid. 72, 4376 (1975); A.S. Horn, M.L. Post and O. Kennard, J. Pharm. Pharmac. 27, 553 (1975); L.L. Iversen, Science 188, 1084 (1975).

    Google Scholar 

  15. B.J. Ludwig and J.R. Potterfield, Adv. Pharmac. Chemother. 9, 173 (1971).

    Article  Google Scholar 

  16. The Benzodiazepines (Eds. S. Garattini, E. Mussini and L.O. Randall; Raven Press, New York 1973 ).

    Google Scholar 

  17. L. H. Sternbach, Agents and Actions 2, 193 (1972).

    Article  Google Scholar 

  18. E. Costa, A. Guidotti, C. C. Mao and A. Suria, Life Sci. 17, 167 (1975).

    Article  Google Scholar 

  19. M.H. Bickel, Prog. Drug. Res. 11, 121 (1968).

    Google Scholar 

  20. W. Schindler and F. Haefliger, Helv. Chim. Acta 37, 472 (1954).

    Article  Google Scholar 

  21. G.L. Klerman and J.CX Cole, Pharm. Rev. 17, 101 (1965).

    Google Scholar 

  22. R. Kuhn, Schweiz, med. Wschr. 87, 1135 (1957).

    Google Scholar 

  23. W. E. Crill, Ann. int. Med. 79, 844 (1973).

    Google Scholar 

  24. K. Stach and W. Pöldinger, Prog. Drug Res. 9, 129 (1966); M. Wilhelm and R. Kuhn, Psycho-Neuropharmak. 3, 317 (1970).

    Google Scholar 

  25. B.E. Leonard, Int. Rev. Neurobiol. 18, 357 (1975); A. Carlsson, Pharmakopsych. 9, 2 (1976).

    Google Scholar 

  26. A. Pletscher, K. F. Gey and P. Zeller; Prog. Drug Res. 2, 417 (1960).

    Google Scholar 

  27. Monoamine Oxidases — New Vistas, Adv. Biochem. Psychopharm. 5 (Eds. E. Costa and M. Sandler; Raven Press, New York 1972 ); N.H. Neff and H.-Y.T. Yang, Life Sci. 14, 2061 (1974).

    Google Scholar 

  28. E. Marley and B. Blackwell, Adv. Pharmac. Chemother. 8, 185 (1970).

    Article  Google Scholar 

  29. Symposium on Vivalan, J. Int. Med. Res. 3, Suppl.3, 1–125 (1975); D.T. Greenwood, K.B. Mallion, A.H. Todd and R. W. Turner, J. Med. Chem. 18, 573 (1975).

    Google Scholar 

  30. F. Hahn, Pharm. Rev. 12, 447 (1960).

    Google Scholar 

  31. Analgetics, in: Medicinal Chemistry, Vol.5 (Ed. G. deStevens; Academic Press, New York 1965); Narcotic Antagonists (Eds. M.C. Braude, L.S. Harris, E.L. May, J.P. Smith and J.E. Villareal; Raven Press, New York 1974); E.J. Fellows and G.E. Ullyot, in: Medicinal Chemistry, Vol.1 (Ed. C.M. Suter; Wiley, New York 1951), p. 390; J. Lee, ibid., p.438; N.B. Eddy and E.L. May, Science 181, 407 (1973); W.B. Loan and J.D. Morrison, Drugs 5, 108 (1973); J. W. Lewis, K. W. Bentley and A. Cowan, Ann. Rev. Pharmac. 11, 241 (1971); S. Archer and L.S. Harris, Prog. Drug Res. 8, 261 (1965).

    Google Scholar 

  32. T.P. Carney, in: Medicinal Chemistry, Vol. 3 (Eds. F. Blicke and R.H. Cox, Wiley, New York 1956 ), p. 1.

    Google Scholar 

  33. R. R. Miller, A. Feingold and J. Paxinos, J. Am. Med. Ass. 213, 996 (1970).

    Article  Google Scholar 

  34. R.N. Brogden, T.M. Speight and G.S. Avery, Drugs 5, 6 (1973).

    Article  Google Scholar 

  35. J. Hughes, T.W. Smith, H.W. Kosterlitz, L.A. Fothergill, B.A. Morgan and H. R. Morris, Nature 258, 511 (1975); A. Goldstein, Science 193, 1081 (1976).

    Google Scholar 

  36. A.F. Bradbury, D.G. Smyth and C.R. Snell, Nature 260, 165 (1976); B.P. Roques, C. Garbay-Jaureguiberry, R. Oberlin, M. Anteunis and A.K. Lala, ibid. 262, 778 (1976); C.R. Jones, W. A. Gibbons and V. Garsky, ibid. 262, 779 (1976).

    Google Scholar 

  37. C. A. Winter, Prog. Drug Res. 10, 139 (1966); M.W. Whitehouse, ibid. 8, 321 (1965); J. Parkhouse, Drugs 10, 366 (1975); C.J. Smyth and J.F. Bravo, ibid. 10, 394 (1975); E. G. McQueen, ibid. 6, 104 (1973).

    Google Scholar 

  38. H. Dreser, Pflügers Arch. ges. Physiol. 76, 306 (1899).

    Google Scholar 

  39. Voltaren (Ed. F.J. Wagenhäuser; Huber, Bern 1976 ).

    Google Scholar 

  40. R.N. Brogden, T.M. Speight and G.S. Avery, Drugs 8, 168 (1974).

    Article  Google Scholar 

  41. R.N. Brogden, R.M. Pinder, P.R. Sawyer, T.M. Speight and G.S. Avery, Drugs 9, 326 (1975).

    Article  Google Scholar 

  42. A.B. Gutman, Adv. Pharmac. 4, 91 (1966).

    Article  Google Scholar 

  43. Local Anesthetics, Vol. 1, Int. Encyclopedia of Pharmacology and Therapeutics, sect. 8, (Ed. P. Lechat; Pergamon, Oxford 1971); H. Grasshof, Prog. Drug Res. 4, 353 (1962); T.P. Carney, in: Medicinal Chemistry, Vol. 1 (Ed. C.M. Suter; Wiley, New York 1951), p. 280; J. Adriani, Clin. Pharmac. Ther. 1, 645 (1960).

    Google Scholar 

  44. T. Narahashi and D.T. Frazier, Neurosci. Res. 4, 65 (1971); J.M. Ritchie and P. Greengard, Ann. Rev. Pharmac. 6, 405 (1966).

    Google Scholar 

  45. E. Renk and W.G. Stoll, Prog. Drug Res. 11, 226 (1968); Antikoagulantien, Handb. exp. Pharm., Vol. 27 (Ed. F. Markwardt; Springer, Berlin 1971 ); A. S. Gallus and J. Hirsh, Drugs 12, 41, 132(1976).

    Google Scholar 

  46. Cardiac Stimulant Substances (R.H. Thorp and L.B. Cobbin), in: Medicinal Chemistry, Vol.6 (G. deStevens; Academic Press, New York 1967 ).

    Google Scholar 

  47. R. Thomas, J. Boutagy and A. Gelbart, J. Pharm. Sci. 63, 1649 (1974).

    Article  Google Scholar 

  48. G. Kroneberg, Actual, pharmac. 25, 157 (1972).

    Google Scholar 

  49. A. Schwartz, G.E. Lindenmayer and J.C. Allen, Pharmac. Rev. 27, 3 (1975); K.S. Lee and W. Klaus, Pharmac. Rev. 23, 193 (1971); Symposium, Ann. N.Y. Acad. Sci. 242, 1–741 (1974); J.L. Dahl and L.E. Hokin, Ann. Rev. Biochem. 43, 327 (1974).

    Google Scholar 

  50. L. Szekeres and J.G. Papp, Prog. Drug Res. 12, 292 (1968); A.L. Bassett and A. L. Wit: ibid. 17, 33 (1973); D.T. Mason, A.N. Demaria, E.A. Amsterdam, R. Zelis and R. A. Massumi, Drugs 5, 261, 292 (1973); B.N. Singh and O. Hauswirth, Am. Heart J. 87,367 (1974); E. M. Vaughan Williams, Adv. Drug Res. 9,69 (1974); P. H. MORGAN and I. W. Mathison, J. Pharm. Sci. 65, 467, 635 (1976).

    Google Scholar 

  51. Organic Nitrates, Handb. exp. Pharm., Vol.40 (Ed. P. Needleman; Springer, Berlin 1975 ).

    Google Scholar 

  52. R. Charlier, Antianginal Drugs, Handb. exp. Pharm., Vol.31 (Springer, Berlin 1971); J. R. Parratt, Adv. Drug Res. 9, 103 (1974).

    Google Scholar 

  53. Antihypertensive Agents (Ed. E. Schüttler), in: Medicinal Chemistry, Vol.7 (Ed. G. deStevens; Academic Press, New York4967); A. Marxer and O. Schier, Prog. Drug Res. 13, 101 (1969); Symposium on Hypertension, Drugs 11, Suppl. 1, 1–204 (1976).

    Google Scholar 

  54. G. Sen and K.C. Bose, Indian med. Wld 2, 194 (1931).

    Google Scholar 

  55. R. J. Vakil, Br. Heart J. 11, 350 (1949).

    Article  Google Scholar 

  56. J. M. Müller, E. Schlittler and H. J. Bein, Experientia 8, 338 (1952).

    Article  Google Scholar 

  57. F. Gross, J. Druey and R. Meier, Experientia 6, 19 (1950).

    Article  Google Scholar 

  58. J.H. Burn and H.H. Dale, J. Pharmac. exp. Ther. 6, 417 (1914/15).

    Google Scholar 

  59. K. Nädor, Prog. Drug Res. 2, 297 (1960).

    Google Scholar 

  60. P.N. Patil, D.D. Miller and U. Trendelenburg, Pharmac. Rev. 26, 323 (1974).

    Google Scholar 

  61. R.P. Ahlquist, A.M. Karow, Jr., and M.W. Riley, Prog. Drug Res. 15, 103 (1971); J.H. Biel and B.K.B. Lum, ibid. 10, 46 (1966).

    Google Scholar 

  62. R.N. Brogden, T.M. Speight and G.S. Avery, Drugs 9, 165 (1975).

    Google Scholar 

  63. T.L. Sourkes, Arch. Biochem. Biophys. 51, 444 (1954); J. A. Oates, L. Gillespie, S. Udenfriend and A. Sjoerdsma, Science 131, 1890 (1960).

    Google Scholar 

  64. G.E. Ullyot and J.F. Kerwin, in: Medicinal Chemistry, Vol.2 (Eds. F.F. Blicke and C. M. Suter; Wiley, New York 1956), p. 234; J.D.P. Graham, Prog. med. Chem. 2, 132 (1962).

    Google Scholar 

  65. S.M. Kupchan and A.W. By, in: The Alkaloids, Vol.10 (Ed. R.H.F. Manske; Academic Press, New York 1967), p. 193; J. Tomko and Z. VofiCKi, ibid., Vol. 14, p. 1.

    Google Scholar 

  66. Diuretics, in: Medicinal Chemistry, Vol. 1 (Ed. G. deStevens; Academic Press, New York 1963); Diuretica, Handb. exp. Pharm., Vol.24 (Ed. H. Herken; Springer, Berlin 1969); D. L. Davees and G.M. Wilson, Drugs 9, 178 (1975); J.E. Baer and K.H. Beyer, Prog. Biochem. Pharmac. 7, 59 (1972).

    Google Scholar 

  67. T. H. Maren, Physiol. Rev. 47, 595 (1967).

    Google Scholar 

  68. R.N. Brogden, T.M. Speight and G.S. Avery, Drugs 9, 4 (1975); Symposium on Bumetanide, Postgrad, med. J. 51, Suppl. 6, 1–98 (1975).

    Google Scholar 

  69. G. Thuillier, J. Laforest, B. Cariou, P. Bessin, J. Bonnet and J. Thuillier, Eur. J. Med. Chem.-Chim. ther. 9, 625 (1974).

    Google Scholar 

  70. G. Destevens, W.L. Bencze and R. Hess, Prog. Drug Res. 13, 217 (1969); Lipid Pharmacology (Ed. R. Paoletti) in: Medicinal Chemistry, Vol.2 (Ed. G. deStevens; Academic Press, New York 1964); E.-C. Witte, Prog. Med. Chem. 11, 119 (1975); R. Howe, Adv. Drug Res. 9, 1 (1974); Hypolipidemic Agents, Handb. exp. Pharm., Vol.41, (Ed. D. Kritchevsky; Springer, Berlin 1975); Pharmacological Control of Lipid Metabolism, Adv. exp. Med. Biol. 26 (Eds. W. L. Holmes, R. Paoletti and D. Kritchevsky; Plenum, New York 1972); R.I. Levy and B.M. Rifkind, Drugs 6, 12 (1973).

    Google Scholar 

  71. Catecholamines, Handb. exp. Pharm., Vol.33 (Eds. H. Blaschko and E. Muscholl; Springer, Berlin 1972 ); G. Burnstock and M. Costa, Adrenergic Neurones ( Chapman and Hall, London 1975 ).

    Google Scholar 

  72. R.M. Pinder, R.N. Brogden, P.R. Sawyer, T.M. Speight and G.S. Avery, Drugs 10, 241 (1975).

    Article  Google Scholar 

  73. A. S. Rebuck, Drugs 7, 344, 370 (1974).

    Article  Google Scholar 

  74. Symposium on Salbutamol, Postgrad, med. J. 47, March Suppl., 1–133 (1971).

    Google Scholar 

  75. P. Aeberli, P. Eden, J.H. Gogerty, W.J. Houlihan and C. Penberthy, J. Med. Chem. 18, 177, 182 (1975).

    Google Scholar 

  76. R.B. Burtner, in: Medicinal Chemistry, Voll (Ed. C.M. Suter; Wiley, New York 1951), p. 151; T.D. Inch and R.W. Brimblecombe, Int. Rev. Neurobiol. 16, 67 (1974); A.F. Casy, Prog. Med. Chem. 11, 1 (1975); A. Karlin, Life Sci. 14, 1385 (1974).

    Google Scholar 

  77. K. Miescher and K. Hoffmann, Helv. Chim. Acta 24, 458 (1941).

    Article  Google Scholar 

  78. Neuromuscular Blocking and Stimulating Agents, Vol. 1 Int. Encyclopedia of Pharmacology and Therapeutics, sect. 14 (Ed. J. Cheymol; Pergamon, Oxford 1972); A. Weber and J. M. Murray, Physiol. Rev. 53,612 (1973); Neuromuscular Junction, Handb. exp. Pharm., Vol. 42 (Ed. E. Zaimis; Springer, Berlin 1976 ).

    Google Scholar 

  79. M.R. Bennett, Autonomic Neuromuscular Transmission (Cambridge University Press, London 1972); C.J. Cavallito and A.P. Gray, Prog. Drug Res. 2, 135 (1960); W.R. Buckett, Adv. Drug Res. 10, 53 (1975).

    Google Scholar 

  80. C.M. Smith, Relaxants of Skeletal Muscle, in: Physiol. Pharmac. 2, part B ( Academic Press, New York 1965 ), p. 2.

    Google Scholar 

  81. R. N. Brogden, T. M. Speight and G. S. Avery, Drugs 8, 1 (1974).

    Article  Google Scholar 

  82. K. Obata, Int. Rev. Neurobiol. 15, \61 (1972); B.S. Meldrum, ibid. 17, 1 (1975); E. Roberts, Biochem. Pharmac. 23, 2637 (1974).

    Google Scholar 

  83. O. Hornykiewicz, Adv. Neurol. 9, 155 (1975); L.J. Poirier, ibid. 9, 327 (1975); A. Barbeau, Ann. Rev. Pharmac. 14, 91 (1974); R.M. Pinder, Prog. Med. Chem. 9, 191 (1973).

    Google Scholar 

  84. H. Ehringer and O. Hornykiewicz, Klin. Wschr. 38, 1236 (1960).

    Article  Google Scholar 

  85. W. Birkmayer and O. Hornykiewicz, Wien. klin. Wschr. 73, 787 (1961).

    Google Scholar 

  86. L-Dopa and Parkinsonism (Eds. A. Barbeau and F.H. McDowell; Davis, Philadelphia 1970); O. Hornykiewicz, Life Sci. 15, 1249 (1974); J.R. Bianchine and L. Sunyapri- Dakul, Drugs 6, 364 (1973); R.N. Brogden, T.M. Speight and G.S. Avery, ibid. 2, 262 (1971); Symposium, Clin. Pharmac. Ther. 12, 317–416 (1971).

    Google Scholar 

  87. E.V. Bailey and T.W. Stone, Arch. int. Pharmacodyn. 216, 246 (1975); D. Parkes, Adv. Drug Res. 8, 11 (1974).

    Google Scholar 

  88. W.J. Close and M.A. Spielman, in: Medicinal Chemistry, Vol.5 (Ed. W.H. Härtung; Wiley, New York 1961), p. 1; Anticonvulsant Drugs, Vols. 1 and 2, Int. Encyclopedia of Pharmacology and Therapeutics, sect. 19 (Ed. J. Mercier; Pergamon, Oxford 1973 ).

    Google Scholar 

  89. T. R. Browne and J. K. Penry, Epilepsia 14, 277 (1973).

    Article  Google Scholar 

  90. D. Simon and J. K. Penry, Epilepsia 16, 549 (1975).

    Article  Google Scholar 

  91. G. Meunier, G. Carraz, Y. Meunier, P. Eymard and M. Aimard, Therapie 18, 435 (1963).

    Google Scholar 

  92. G. Taillandier, J. L. Benoit-Guyod, A. Boucherle, M. Broll and P. Eymard, Eur. J. Med. Chem.-Chim. ther. 10, 453 (1975).

    Google Scholar 

  93. Histamine and Antihistamines, Vol. 1, Int. Encyclopedia of Pharmacology and Therapeutics, sect. 74 (Ed. M. Schacter; Pergamon, Oxford 1973); Histamine, Handb. exp. Pharm., Vol. 18, part I (Ed. M. Rocha e Silva; Springer, Berlin 1966 ).

    Google Scholar 

  94. H.H. Dale and P.P. Laidlaw, J. Physiol. 41, 318 (1910).

    Google Scholar 

  95. D. Bovet and A. Staub, C. r. Soc. Biol. 124, 547 (1937).

    Google Scholar 

  96. J.W. Black, W.A.M. Duncan, C.J. Durant, C.R. Ganellin and E.M. Parsons, Nature 236, 385 (1972); N. Chand and P. Eyre, Agents and Actions 5, 277 (1975).

    Google Scholar 

  97. J.S.C. Cox, J.E. Beach, A.M. Blair, A.J. Clarke, J. King, T.B. Lee, D.E.E. Loveday, G.F. Moss, T.S.C. Orr, J.R. Ritchie and P. Sheard, Adv. Drug Res. 5, 115 (1970); R.N. Brogden, T.M. Speight and G.S. Avery, Drugs 7, 164, 283 (1974).

    Google Scholar 

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  1. Chemical Research Department, Pharmaceutical Division, Ciba-Geigy Ltd, Basle, Switzerland

    A. Marxer & O. Schier

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    Ernst Jucker

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Marxer, A., Schier, O. (1976). Fundamental Structures in Drug Research. In: Jucker, E. (eds) Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques, vol 20. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7094-8_12

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