Abstract
One of the major efforts in cholera research in the United States has been the development of a cholera toxoid sufficiently free of somatic antigen that it would be suitable for the detection of any effectiveness that antitoxic immunity may have in preventing or ameliorating clinical cholera. In consideration of the degree of effectiveness of cholera vaccines [8-10] and the case rates of cholera that might be anticipated in various endemic areas [7], the Cholera Advisory Committee of the National Institutes of Health recognized that field trial populations would have to be very large if one wished to detect the effects of antitoxic immunity superimposed upon antibacterial immunity and therefore, from its earliest considerations, the committee established as one of the requirements for a toxoid that it be very low in somatic antigen content. It should be emphasized that the objective of the work to be reported here was the development of a toxoid that would be an experimental tool for the study of antitoxic immunity rather than at this time to develop an immunizing agent of optimal effectiveness.
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© 1975 Birkhäuser Verlag Basel
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Verwey, W.F., Guckian, J.C., Craig, J., Pierce, N., Peterson, J., Williams, H. (1975). The Current Status of Cholera Toxoid Research in the United States. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 19. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7090-0_69
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DOI: https://doi.org/10.1007/978-3-0348-7090-0_69
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