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Abstract

It will not be an overstatement to say that the value of studies on tetanus passes far beyond the limits of this particular problem. Here, in this small streamlet, lies the branch of a big river of medical science. Its history was pleased to arrange the events in such a way that many discoveries marking an epoch in general and infectious pathology and laying the foundation of theoretical and practical immunology, seroprophylaxis and serotherapy were made in the course of studying tetanus.

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References

  1. V. B.Brooks, D. R. Curtis and J. C. Ecceles, The Action of Tetanus Toxin on the Inhibition of Motoneurons, J. Physiol., Lond. 135, 655–672 (1957).

    Google Scholar 

  2. D. D’antona, Le tétanos, Synthèse théorique et pratique de nos principles connaissance, Rev. Immun. 15, 93–157 (1951).

    Google Scholar 

  3. U. Friedemann, A. Hollander and J. M. Tarlov, Investigations on the Pathogenesis of the Tetanus, J. Immun. 40, 325–364 (1941).

    Google Scholar 

  4. III International Conference on Tetanus, Säo Paulo, Brazil 1970, Collection of Abstracts.

    Google Scholar 

  5. G. N. Kryzhanovsky, Tetanus (State Publish. House ‘Medicine’, Moscow 1966, in Russian).

    Google Scholar 

  6. G. N. Kryzhanovsky: Its Transport to the Central Nervous System and State of the Spinal Reflex Apparatus in Tetanus Intoxication, in: Principles on Tetanus (Ed. L. Eckmann; H. Huber, Bern-Stuttgart 1967 ), p. 155–168.

    Google Scholar 

  7. G. N. Kryzhanovsky, Some Foundamental Problems of Tetanus Pathogenesis, in: Third International Conference on Tetanus (Pan Am. Hlth Organ., Washington 1972 ), p. 72–78.

    Google Scholar 

  8. G. N. Kryzhanovsky, The Mechanism of Action of Tetanus Toxin: Effect on Synaptic Processes and Some Particular Features of Toxin Binding by the Nervous Tissue, Naunyn-Schmiedeberg’s Arch. Pharmac. 276, 247–270 (1973).

    Article  Google Scholar 

  9. G. N. Kryzhanovsky, L. A. Pevnitsky, V. N. Grafova and A. A. Polgar; Routes of Tetanus Toxin Entrance into the Central Nervous System and Some Problems of Pathogensis of Experimental Tetanus. Reports I, II, III, IV, Byull. éksp. Biol. Med. 51 (3), 42–49; 52 (8), 31–37; 52 (11), 35–43; 52 (12), 30–37 (1961).

    Google Scholar 

  10. A. Marie and V. Morax, Recherches sur l’absorption de la toxine tétanique, Ann. Inst. Pasteur 18, 818–832 (1902).

    Google Scholar 

  11. J. Mellanby and W. E. Van Heyningen, The Role of Ganglioside in the Mode of Action of Tetanus Toxin, in: Recent Advances in the Pharmacology of Toxins (Ed. H. W. Raudonat; Pergamon Press, Czechoslovakia Medical Press, Oxford-Praha 1965 ), p. 121–123.

    Google Scholar 

  12. J. Mellanby and W. E. Van Heyningen, Biochemical Research on the Mode of Action of Tetanus Toxin, in: Principles on Tetanus (Ed. L. Eckmann; H. Huber, Bern-Stuttgart 1967 ), p. 177–189.

    Google Scholar 

  13. J. Mellanby, W. E. Van Heyningen and V. P. Whittaker, Fixation of Tetanus Toxin by Subcellular Fractions of Brain, J. Neurochem. 12, 77–79 (1965).

    Article  Google Scholar 

  14. H. Meyer and F. Ransom, Untersuchungen über den Tetanus, Arch. exp. Pathol. Pharmakol. 49, 369–416 (1903).

    Article  Google Scholar 

  15. W. E. Van Heyningen, The Fixation of Tetanus Toxin by Nervous Tissue, J. gen. Microbiol. 20, 291–300 (1959).

    Google Scholar 

  16. W. E. Van Heyningen, Chemical Assay of the Tetanus Toxin Receptor in Nervous Tissue, J. gen. Microbiol. 20, 301–309 (1959).

    Google Scholar 

  17. W. E. Van Heyningen, Tentative Identification of the Tetanus Receptor in Nervous Tissue, J. gen. Microbiol. 20, 310–320 (1959).

    Google Scholar 

  18. W. E. Van Heyningen and P. M. Miller, The Fixation of Tetanus Toxin by Ganglioside, J. gen. Microbiol. 24, 107–119 (1961).

    Google Scholar 

  19. E. A. Wright, R. S. Morgan and G. P. Wright, The Site of Action of the Toxin in Local Tetanus, Lancet 2, 316–319 (1952).

    Article  Google Scholar 

  20. G. P. Wright, The Neurotoxins of Clostridium Botulinum and Clostridium Tetani, Pharmac. Rev. 7, 413–465 (1955).

    Google Scholar 

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© 1975 Birkhäuser Verlag Basel

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Kryzhanovsky, G.N. (1975). Tetanus: General and Pathophysiological Aspects; Achievements, Failures, Perspectives of Elaboration of the Problem. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 19. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7090-0_35

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  • DOI: https://doi.org/10.1007/978-3-0348-7090-0_35

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7092-4

  • Online ISBN: 978-3-0348-7090-0

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