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New Perspectives on the Chemotherapy of Malaria, Filariasis, and Leprosy

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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

Abstract

The great advances made in chemotherapy during this century have enabled some measure of control of the major killing diseases of the tropics. Notwithstanding past progress, man today is confronted by a catalog of challenging problems, and the incentive to develop novel and improved antiinfective agents has not diminished. Adequate drugs are still lacking for the treatment of many chronic and debilitating diseases including leishmaniasis, Chagas’ disease, filariasis, schistosomiasis, clonorchiasis, trichuriasis, strongyloidiasis, and leprosy. Moreover, reports of drug resistance have often followed advances in chemotherapy like a ‘faithful shadow’, and this shadow will no doubt lengthen in the future. The philosophy of global eradication of communicable diseases [1] and the evolution of techniques for its achievement have added a new dimension to research in parasite chemotherapy, namely the urgent need for drugs with protracted action. While the clinician interested in treating an individual often has a variety of good drugs at his disposal and may feel little need for new agents, the public health worker, whose aim is the ultimate eradication of a disease from an entire community, faces problems of a magnitude and type not encountered by the clinician and is frequently unable to achieve his objective of total coverage with currently available drugs. Future progress in parasite chemotherapy will depend mainly on an increased awareness of such critical problems and needs and on appropriate recognition of biochemical processes within both parasite and host. Intensive efforts to develop useful agents for the treatment of parasitic diseases of livestock, poultry, and other domestic animals have also yielded a variety of promising new substances, and the benefits derived from interplay between human and veterinary research are already apparent.

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References

  1. E. H. Hinman, Am. J. trop. Med. Hyg. 15, 125 (1966).

    Google Scholar 

  2. WHO Chronicle 19, 339 (1965).

    Google Scholar 

  3. L. J. Bruce-Chwatt, Trans. R. Soc. trop. Med. Hyg. 59, 105 (1965).

    Article  Google Scholar 

  4. E. F. Elslager and P. E. Thompson, Ann. Rev. Pharmac. 2, 193 (1962).

    Article  Google Scholar 

  5. P. E. Thompson, B. J. Olszewski, E. F. Elslager and D. F. Worth, AM. J. trop. Med. Hyg. 12, 481 (1963).

    Google Scholar 

  6. Resolution, ibid. 13, 361 (1964).

    Google Scholar 

  7. Wld Hth Org. tech. Rep. Ser. 296 (1965).

    Google Scholar 

  8. P. E. Thompson and L. M. Werbel, in: Medicinal Chemistry, Vol. 12 (Ed. G. deStevens; Academic Press, New York 1972 )

    Google Scholar 

  9. W. Peters, Chemotherapy and Drug Resistance in Malaria ( Academic Press, London 1970 ).

    Google Scholar 

  10. E. A. Steck, The Chemotherapy of Protozoan Diseases, Vol. 3 ( Walter Reed Army Institute of Research, Washington, D.C., 1971 ).

    Google Scholar 

  11. Wld Hth Org. tech. Rep. Ser. 529 (1973).

    Google Scholar 

  12. E. F. Elslager, in: Progress in Drug Research, Vol. 13 (Ed. E. Jucker; Birkhäuser Verlag, Basel 1969 ), p. 171–216.

    Google Scholar 

  13. D. G. Davey, in: Experimental Chemotherapy, Vol. 1 (Ed. J. R. Schnitzer and F. Hawking; Academic Press, New York 1963 ), p. 487.

    Google Scholar 

  14. D. F. Clyde, V. C. McCarthy, H. L. DuPont and R. B. Hornick, J. trop. Med. Hyg. 76, 54 (1973).

    Google Scholar 

  15. P. E. Thompson, B. Olszewski, A. Bayles and J. A. Waitz, Am. J. trop. Med. Hyg. 16, 133 (1967).

    Google Scholar 

  16. K. H. Rieckmann, J. Am. med. Ass. 217, 573 (1971).

    Article  Google Scholar 

  17. L. H. Schmidt, presented at a meeting of the WHO Scientific Group on the Chemotherapy of Malaria and Resistance to Antimalarials, Geneva, Switzerland, 17–24 October 1972.

    Google Scholar 

  18. Wld Hth Org. tech. Rep. Ser. 375, 42 (1967).

    Google Scholar 

  19. The author is grateful to the World Health Organization, Geneva, Switzerland, for permission to reproduce Table 4 and Fig. 1.

    Google Scholar 

  20. R. L. DeGowin and R. D. Powell, Am. J. trop. Med. Hyg. 14, 519 (1965).

    Google Scholar 

  21. R. D. Powell, G. J. Brewer, R. L. DeGowin and A. S. Alving, Bull. Wld Hlth Org. 31, 379 (1964).

    Google Scholar 

  22. D. F. Clyde, R. M. Miller, H. L. DuPont and R. B. Hornick, J. Am. med. Ass. 213, 2041 (1970).

    Article  Google Scholar 

  23. D. Willerson, Jr., K. H. Rieckmann, L. Kass, P. E. Carson, H. Frischer, L. Richard and J. E. Bowman, Milit. Med. 139, 175 (1974).

    Google Scholar 

  24. D. F. Clyde, N. Hlaing and F. Tin, Trans. R. Soc. trop. Med. Hyg. 66, 369 (1972).

    Article  Google Scholar 

  25. D. F. Clyde, V. C. McCarthy, R. H. Gilman and R. M. Miller, J. trop. Med. Hyg. 76, 226 (1973).

    Google Scholar 

  26. R. B. Angier, J. H. Boothe, B. L. Hutchins, J. H. Mowat, J. Semb, E. R. L. Stokstad, Y. Subbarow, C. W. Waller, D. B. Cosulich, M. J. Fahrenbach, M. E. Hultquist, E. Kuh, E. H. Northey, D. R. Seeger, J. P. Sickels and J. M. Smith, Jr., Science 103, 667 (1946).

    Article  Google Scholar 

  27. D. R. Seeger, D. B. Cosulich, J. M. Smith, Jr., and M. E. Hultquist, J. Am. chem. Soc. 71, 1753 (1949).

    Article  Google Scholar 

  28. G. H. Hitchings and J. J. Burchall, in: Advances in Enzymology, Vol. 27 (Ed. F. F. Nord; Interscience Publishers, New York 1965 ), p. 417–468.

    Google Scholar 

  29. H. C. Carrington, A. F. Crowther, D. G. Davey, A. A. Levi and F. L. Rose, Nature 168, 1080 (1951).

    Google Scholar 

  30. B. R. Baker, Design of Active-Site-Directed Irreversible Enzyme Inhibitors ( John Wiley Inc., New York 1967 ), p. 192–284.

    Google Scholar 

  31. R. L. Blakley, in: Frontiers of Biology, Vol. 13 (Ed. A. Neuberger and E. L. Tatum; North- Holland Publishing Co., Amsterdam 1969 ).

    Google Scholar 

  32. J. Greenberg and E. M. Richeson, Proc. Soc. exp. Biol. Med. 77, 174 (1951).

    Google Scholar 

  33. J. Greenberg and H. W. Bond, J. Parasit. 40, 472 (1954).

    Article  Google Scholar 

  34. E. A. Falco, L. G. Goodwin, G. H. Hitchings, I. M. Rollo and P. B. Russell, Brit. J. Pharmac. Chemother. 6, 185 (1951).

    Google Scholar 

  35. J. Davoll, A. M. Johnson, H. J. Davies, O. D. Bird, J. Clarke and E. F. Elslager, J. Med. Chem. 15, 812 (1972).

    Google Scholar 

  36. P. E. Thompson, A. Bayles and B. Olszewski, Exp. Parasit. 25, 32 (1969).

    Article  Google Scholar 

  37. For a recent extensive review, see E. F. Elslager and J. Davoll: Lectures in Heterocyclic Chemistry, Vol. 2 (Ed. R. N. Castle; Journal of Heterocyclic Chemistry, Orem, Utah 1973 ).

    Google Scholar 

  38. J. Davoll, A. M. Johnson, J. Dickinson, O. D. Bird, J. Clarke and E. F. Elslager, manuscript in preparation (1974).

    Google Scholar 

  39. J. Davoll, A. M. Johnson, J. Dickinson, O. D. Bird, J. Clarke and E. F. Elslager, manuscript in preparation (1974).

    Google Scholar 

  40. E. F. Elslager, S. C. Perricone and D. F. worth, manuscript in preparation (1974).

    Google Scholar 

  41. E. F. Elslager, O. D. Bird, J. Clarke, S. C. Perricone, D. F. Worth and J. Davoll, J. Med. Chem. 15, 1138 (1972).

    Article  Google Scholar 

  42. For a description of the test methods see [36] and [43].

    Google Scholar 

  43. P. E. Thompson, A. Bayles and B. Olszewski, Am. J. trop. Med. Hyg. 19, 12 (1970).

    Google Scholar 

  44. For a description of the test method, see T. S. Osdene, P. B. Russell and L. Rane, J. Med. Chem. 10, 431 (1967).

    Google Scholar 

  45. J. Davoll and A. M. Johnson, J. chem. Soc. C, p. 997 (1970).

    Google Scholar 

  46. O. D. Bird, J. W. Vaitkus and J. Clarke, Molec. Pharmac. 6, 573 (1970).

    Google Scholar 

  47. D. J. Hutchison, F. M. Sirotnak and A. M. Albrecht, Proc. Am. Ass. Cancer Res. 10, 41 (1969).

    Google Scholar 

  48. D. J. Hutchison, Cancer Chemother. Rep. 52, part 1, 697 (1968).

    Google Scholar 

  49. M. Shimoyama and D. J. Hutchison, Proc. Am. Ass. Cancer Res. 10, 80 (1969).

    Google Scholar 

  50. E. F. Elslager, J. Johnson and L. M. Werbel, unpublished results (1973).

    Google Scholar 

  51. E. F. Elslager, L. Newton and L. M. Werbel, unpublished results (1973).

    Google Scholar 

  52. E. F. Elslager, J. Clarke, L. M. Werbel, D. F. Worth and J. Davoll, J. Med. Chem. 15, 827 (1972).

    Article  Google Scholar 

  53. E. F. Elslager, J. Davoll, L. M. Werbel and D. F. Worth, Abstracts of Papers, Third International Congress of Heterocyclic Chemistry, Sendai, Japan, 23–27 August 1973, p. 366–369.

    Google Scholar 

  54. E. F. Elslager, J. Johnson, L. M. Werbel and J. Davoll, Abstracts of Papers, 163rd National Meeting of the American Chemical Society, Boston, Mass., 9–14 April 1972, MEDI 36.

    Google Scholar 

  55. E. F. Elslager, J. Clarke, J. Johnson, L. M. Werbel and J. Davoll, J. Heterocyc. Chem. 9, 759 (1972).

    Article  Google Scholar 

  56. E. F. Elslager, J. Davoll, P. Jacob, A. M. Johnson, J. Johnson and L. M. Werbel, manuscript in preparation (1973).

    Google Scholar 

  57. E. F. Elslager, P. Jacob, J. Johnson, L. M. Werbel, D. F. Worth and L. Rane, manuscript in preparation (1973).

    Google Scholar 

  58. P. E. Thompson, presented at the Antifolate Conference, Walter Reed Army Institute of Research, Washington, D.C., April 1971.

    Google Scholar 

  59. L. Rane and D. S. Rane, Proc. Helminthol. Soc. Wash. 39, 283 (1972).

    Google Scholar 

  60. L. H. Schmidt, presented at the WHO Technical Meeting on the Chemotherapy of Malaria, Geneva, Switzerland, October 1972.

    Google Scholar 

  61. L. H. Schmidt, Trans. R. Soc. trop. Med. Hyg. 67, 446 (1973).

    Article  Google Scholar 

  62. F. H. S. Curd and F. L. Rose, J. chem. Soc. p. 729 (1946).

    Google Scholar 

  63. F. H. S. Curd and F. L. Rose, J. chem. Soc. p. 362 (1946).

    Google Scholar 

  64. F. H. S. Curd, D. G. Davey and F. L. Rose, Ann. trop. Med. Parasit. 39, 157 (1945).

    Google Scholar 

  65. F. H. S. Curd, D. G. Davey and F. L. Rose, Ann. trop. Med. Parasit. 39, 139 (1945).

    Google Scholar 

  66. F. H. S. Curd, D. G. Davey and F. L. Rose, Ann. trop. Med. Parasit. 39, 208 (1945).

    Google Scholar 

  67. J. Williamson, D. S. Bertram and E. M. Lourie, Nature, Lond. 159, 885 (1947).

    Article  Google Scholar 

  68. J. Williamson and E. M. Lourie, Ann. trop. Med. Parasit. 41, 278 (1947).

    Google Scholar 

  69. J. P. Thurston, Parasitology 43, 246 (1953).

    Article  Google Scholar 

  70. J. Singh, A. P. Ray, P. C. Basu and C. P. Nair, Trans. R. Soc. trop. Med. Hyg. 46, 639 (1952).

    Article  Google Scholar 

  71. J. Singh, C. P. Nair and A. P. Ray, Indian J. Malariol. 8, 187 (1954).

    Google Scholar 

  72. E. F. Elslager, L. M. Werbel, A. Curry, N. Headen and J. Johnson, Abstracts of Papers, 165th National Meeting of the American Chemical Society, Dallas, Tex., 9–12 April 1973, MEDI 46.

    Google Scholar 

  73. E. F. Elslager, L. M. Werbel, A. Curry, N. Headen and J. Johnson, J. Med. Chem. 77, 75 (1974).

    Article  Google Scholar 

  74. T. R. Sweeney and D. P. Jacobus, Abstracts of Papers, 12th National Medicinal Chemistry Symposium of the American Chemical Society, Seattle, Wash., 22–25 June 1970, p. 7d, 7z.

    Google Scholar 

  75. F. Hawking, in: Experimental Chemotherapy, Vol. 1 (Ed. R. J. Schnitzer and F. Hawking; Academic Press, New York1963), p. 893 seqq

    Google Scholar 

  76. K. M. Cahill, N.Y. State J. med. 63, 1379, 1551 (1953).

    Google Scholar 

  77. R. N. Stoll, J. Parasit. 33, 1 (1947).

    Article  Google Scholar 

  78. Wld Hlth Org. tech. Rep. Ser. 359 (1967).

    Google Scholar 

  79. R. I. Hewitt, S. Kushner, H. W. Stewart, E. White, W. S. Wallace and Y. Subbarow, J. Lab. clin. Med. 32, 1314 (1947).

    Google Scholar 

  80. P. E. Thompson, L. Boche and L. S. Blair, J. Parasit. 54, 834 (1968).

    Article  Google Scholar 

  81. J. H. Burckhalter, F. H. Tendick, E. M. Jones, P. S. Jones, W. F. Holcomb and A. L. Rawlings, J. Am. chem. Soc. 70, 1363 (1948).

    Article  Google Scholar 

  82. N. N. Singh and P. C. Basu, personal communication (1967).

    Google Scholar 

  83. E. F. Elslager, S. C. Perricone and F. H. Tendick, J. Med. Chem. 12, 965 (1969).

    Article  Google Scholar 

  84. E. F. Elslager, Abstracts of Papers, Conference on the Chemotherapy of Filariasis, Johns Hopkins School of Hygiene and Public Health, Baltimore, Md., 1 - 2 June 1970.

    Google Scholar 

  85. E. F. Elslager, S. C. Perricone and D. F. Worth, J. Heterocyc. Chem. 7, 543 (1970).

    Article  Google Scholar 

  86. J. H. Burckhalter, J. Am. pharm. Ass. Sci. Ed. 38, 658 (1949).

    Article  Google Scholar 

  87. W. L. Nobles, R. F. Tietz, Y. S. Koh and J. H. Burckhalter, J. pharm. Sci. 52, 600 (1963).

    Article  Google Scholar 

  88. E. F. Elslager, E. H. Gold, F. H. Tendick, L. M. Werbel and D. F. Worth, J. Heterocyc. Chem. 1, 6 (1964).

    Article  Google Scholar 

  89. E. F. Elslager, F. H. Tendick and L. M. Werbel, J. Med. Chem. 12, 600 (1969).

    Article  Google Scholar 

  90. F. Y. Wiselogle, A Survey of Antimalarial Drugs, 1941–1945, 2 vol. (J. W. Edwards, Ann Arbor, Mich., 1946 ).

    Google Scholar 

  91. J. Schneider, M. Bouvry and J. LeQuellec, Ann. Soc. Beige Med. trop. 45, 435 (1965).

    Google Scholar 

  92. F. Benazet, Ann. Soc. Beige Med. trop. 45, 459 (1965).

    Google Scholar 

  93. E. F. Elslager, F. H. Tendick, L. M. Werbel and D. F. Worth, J. Med. Chem. 12, 970 (1969).

    Google Scholar 

  94. H. Medenwald, Med. Chem. 5, 206 (1956).

    Google Scholar 

  95. N. B. Ackerman, D. K. Haldorsen, F. H. Tendick and E. F. Elslager, J. Med. Chem. 11, 315 (1968).

    Article  Google Scholar 

  96. E. F. Elslager, R. E. Bowman, F. H. Tendick, D. J. Tivey and D. F. Worth, J. Med. Chem. 5, 1159 (1962).

    Google Scholar 

  97. E. F. Elslager, F. H. Tendick, L. M. Werbel and D. F. Worth, J. Med. Chem. 12, 970 (1969).

    Article  Google Scholar 

  98. E. F. Elslager and D. F. Worth, J. Med. Chem. 12, 955 (1969).

    Article  Google Scholar 

  99. D. M. Besly and A. A. Goldberg, J. chem. Soc. p. 2448 (1954).

    Google Scholar 

  100. E. F. Elslager, A. Curry, N. Headen and L. M. Werbel, manuscript in preparation (1973).

    Google Scholar 

  101. P. E. Thompson and L. Boche, unpublished results (1967).

    Google Scholar 

  102. E. F. Elslager, P. E. Thompson and L. Boche, unpublished results (1973).

    Google Scholar 

  103. L. M. Bechelli and V. M. Dominguez, Bull. Wld Hlth Org. 34, 811 (1966).

    Google Scholar 

  104. Wld Hlth Org. techn. Rep. Ser. 319 (1966).

    Google Scholar 

  105. Y. T. Chang, Antimicrob. Agents Chemother. 1965, 465 (1966).

    Google Scholar 

  106. For a recent review, see L. Doub, in: Medicinal Chemistry, Vol. 5 (Ed. W. H. Hartung; John Wiley, New York 1961 ), p. 350–425.

    Google Scholar 

  107. L. T. Coggeshall, J. Maier and C. A. Best, J. Am. med. Ass. 117, 1077 (1941).

    Article  Google Scholar 

  108. H. M. Archibald and C. M. Ross, J. trop. Med. Hyg. 63, 25 (1960).

    Google Scholar 

  109. E. F. Elslager and P. E. Thompson, Abstracts, 9th National Medicinal Chemistry Symposium of the American Chemical Society, Minneapolis, Minn., June 1964, p. 6A.

    Google Scholar 

  110. E. F. Elslager and D. F. Worth, abstracts of papers, 149th Meeting of the American Chemical Society, Detroit, Mich., 4–9 april 1965, p. 28n.

    Google Scholar 

  111. E. F. Elslager and D. F. Worth, Nature 206, 630 (1964).

    Article  Google Scholar 

  112. P. E. Thompson, B. Olszewski and J. A. Waitz, Am. J. trop. Med. Hyg. 14, 343 (1965).

    Google Scholar 

  113. P. E. Thompson, Int. J. Lepr. 35, 605 (1967).

    Google Scholar 

  114. P. E. Thompson, J. A. Waitz and B. Olszewski, J. Parasit. 51, 345 (1965).

    Article  Google Scholar 

  115. E. F. Elslager, Z. B. Gavrilis, A. A. Phillips and D. F. Worth, J. Med. Chem. 12, 357 (1969).

    Article  Google Scholar 

  116. E. F. Elslager, A. A. Phillips and D. F. Worth, J. Med. Chem. 12, 363 (1969).

    Article  Google Scholar 

  117. D. F. Worth, E. F. Elslager and A. A. Phillips, J. Med. Chem. 12, 591 (1969).

    Article  Google Scholar 

  118. E. F. Elslager, D. B. Capps and D. F. Worth, J. Med. Chem. 12, 597 (1969).

    Article  Google Scholar 

  119. P. E. Thompson, A. Bayles, B. Olszewski and J. A. Waitz, Am. J. trop. Med. Hyg. 14, 198 (1965).

    Google Scholar 

  120. S. P. Ramakrishnan, P. C. Basu, H. Singh and N. Singh, Bull. Wld Hlth Org. 27, 213 (1962).

    Google Scholar 

  121. A. Bishop, Parasitology 53, 10 (1963).

    Google Scholar 

  122. W. Chin, P. G. Contacos, G. R. Coatney, M. H. Jeter and E. Alpert, Am. J. trop. Med. Hyg. 16, 580 (1967).

    Google Scholar 

  123. A. B. G. Laing, G. Pringle and F. C. T. Lane, Am. J. trop. Med. Hyg. 15, 838 (1966).

    Google Scholar 

  124. K. H. Rieckmann, Trans. R. Soc. trop. Med. Hyg. 61, 189 (1967).

    Article  Google Scholar 

  125. D. F. Clyde, Abstracts, Eighth International Congresses on Tropical Medicine and Malaria, Teheran, Iran, 1380, 7–15 September 1968.

    Google Scholar 

  126. R. H. Black, W. B. Hennessy, B. McMillan, B. B. Dew and J. C. Biggs, Med. J. Aust. 2, 808 (1966).

    Google Scholar 

  127. W. Chin, G. R. Coatney and H. K. King, Am. J. trop. Med. Hyg. 16, 13 (1967).

    Google Scholar 

  128. A. J. Glazko, W. A. Dill, R. G. Montalbo and E. L. Holmes, Am. J. trop. Med. Hyg. 77, 465 (1968).

    Google Scholar 

  129. H. H. Gusmao and E. Juarez, Am. J. trop. Med. Hyg. 19, 394 (1970).

    Google Scholar 

  130. C. C. Shepard, Proc. Soc. exp. Biol. Med. 124, 430 (1967).

    Google Scholar 

  131. C. C. Shepard, D. H. McRae and J. A. Habas, Proc. Soc. exp. Biol. Med. 122, 893 (1966).

    Google Scholar 

  132. C. C. Shepard, Int. J. Lepr. 35, 616 (1967).

    Google Scholar 

  133. C. C. Shepard, J. G. Tolentino and D. H. McRae, Am. J. trop. Med. Hyg. 17, 192 (1968).

    Google Scholar 

  134. C. R. Boughton, G. C. Scott, D. A. Russell and D. R. Vincin, Med. J. Aust. 1, 1258 (1971).

    Google Scholar 

  135. D. A. Russell, C. C. Shepard, D. H. Mcrae, G. C. Scott and D. R. Vincin, Am. J. trop. Med. Hyg. 20, 495 (1971).

    Google Scholar 

  136. C. R. Boughton, Lancet 1, 1187 (1972).

    Google Scholar 

  137. C. R. Boughton, Med. J. Aust. 2, 837 (1972).

    Google Scholar 

  138. D. A. Russell, J. H. Peters, D. R. Vincin, G. C. Scott and C. C. Shepard, Abstracts of Papers, Tenth International Leprosy Congress, Bergen, Norway, 13–18 August 1973, p. 4.

    Google Scholar 

  139. D. H. McRae, D. A. Russell, D. R. Vincin, G. C. Scott and C. C. Shepard, Abstracts of Papers, Tenth International Leprosy Congress, Bergen, Norway, 13–18 August 1973, p. 5.

    Google Scholar 

  140. C. R. Boughton, Abstracts of Papers, Tenth International Leprosy Congress, Bergen, Norway, 13–18 August 1973, p. 207.

    Google Scholar 

  141. C. C. Shepard, L. Levy and P. Fasal, Am. J. trop. Med. Hyg. 21, 440 (1972).

    Google Scholar 

  142. N. R. Sloan, R. M. Worth, B. Jano, P. Fasal and c. c. Shepard, Lancet 2, 525 (1971).

    Google Scholar 

  143. N. R. Sloan, R. M. Worth, B. Jano, P. Fasal and C. C. Shepard, Int. J. Lepr. 40, 40 (1972).

    Google Scholar 

  144. N. R. Sloan, R. M. Worth, B. Jano, P. Fasal and C. C. Shepard, Int. J. Lepr. 40, 48 (1972).

    Google Scholar 

  145. R. M. Worth, D. A. Russell and B. Jano, Abstracts of Papers, Tenth International Leprosy Congress, Bergen, Norway, 13–18 August 1973, p. 135.

    Google Scholar 

  146. Editorial, Lancet 2, 534 (1971).

    Google Scholar 

  147. B. G. Lucas, Lancet 2, 1423 (1971).

    Article  Google Scholar 

  148. J. S. Dodge, Lancet 2, 1201 (1971).

    Article  Google Scholar 

  149. E. F. Elslager, A. A. Phillips and D. F. Worth, Abstracts of Papers, 157th Meeting of the American Chemical Society, Minneapolis, Minn., 13–18 April 1969, MEDI 32.

    Google Scholar 

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  1. Department of Chemistry, Research and Development Division, Parke, Davis and Company, Ann Arbor, Michigan, 48106, USA

    Edward F. Elslager

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    Ernst Jucker

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Elslager, E.F. (1974). New Perspectives on the Chemotherapy of Malaria, Filariasis, and Leprosy. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 18. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7087-0_10

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