Abstract
In this review, we are concerned with the most recent advances in single cell cardiac electrophysiology and pharmacology. We have restricted ourselves to research papers that appeared in the 2 years since our last review [1] and additionally certain articles of special interest. The reader is referred to the comprehensive review by SZEKERES and PAPP published in this journal [2] and to the monograph by the same authors for more extensive surveys of the many actions of numerous antiarrhythmic drugs [3]. There also are several recently published reviews and symposia dealing with various aspects of cardiac arrhythmias and therapy [4–12]. We agree with SZEKERES and PAPP [3] that it is almost impossible to completely review the ever increasing number of publications on this subject. One reason for the voluminous literature is the multiple experimental approaches used to attack the problems of arrhythmia formation and the modes of action of antiarrhythmic drugs. Our own approach is based to a great extent on studies utilizing intracellular microelectrode recording techniques [13–15]. This method permits the direct characterization of the electrophysiological properties of single cells in the heart. We will consider and evaluate recent publications concerned with cardiac arrhythmias and antiarrhythmic drugs with particular emphasis on new experimental methods which expand the physiological significance of data obtained through the use of microelectrode recording techniques.
Keywords
- Conduction Velocity
- Antiarrhythmic Drug
- Action Potential Duration
- Membrane Responsiveness
- Purkinje Fiber
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Supported in part by NHLI Grant 12738.
Recipient Career Development Award, NHLI K4-HE-42500.
Senior Investigator of the New York Heart Association.
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References
A. L. Bassett and B. F. Hoffman, Ann. Rev. Pharmac. 11, 143 (1971).
L. Szekeres and J. GY. Papp, Prog. Drug Res. 12, 292 (1968).
L. Szekeres and GY. J. Papp, Experimental Cardiac Arrhythmias and Antiarrhythmic Drugs ( Akadémiai Kiado, Budapest 1971 ).
B. F. Hoffman and J. T. Bigger, Jr., in: Drill’s Pharmacology in Medicine (Mc Graw HÜ1, New York 1970 ), p. 824.
R. L. Katz and J. T. Bigger, Jr., Anesthesiology 33, 193 (1970).
D. T. Mason, J. F. Spann, Jr., R. Zelis and E. A. Amsterdam, Clin. Pharmac. Ther. 11, 460 (1970).
D. T. Mason, R. Zelis, G. Lee, J. L. Hughes, J. F. Spann, Jr., and E. A. amsterdam, Am. J. Cardiol. 27, 546 (1971).
R. Mendez and E. Kabela, Ann. Rev. Pharmac. 10, 291 (1970).
E. Sandoe, E. Flensted-Jensen and K. H. Olesen (Ed.), Symposium on Cardiac Arrhythmias (AB Astra: Södertälje, Sweden 1970 ).
D. B. Scott and D. G. Julian (Ed.), Lidocaine in the Treatment of Ventricular Arrhythmias (E. & S. Livingstone, Edinburgh 1971 ).
D. H. Singer and R. E. Teneick, Prog, cardiovasc. Dis. 11, 488 (1969).
D. H. Singer and R. E. Teneick, Am. J. Cardiol. 28, 381 (1971).
B. F. Hoffman, Prog. Cardiovasc. Dis. 8, 319 (1966).
B. F. Hoffman and P. F. Cranefield, Electrophysiology of the Heart ( McGraw-Hill, NewYork 1960 ).
B. F. Hoffman and P. F. Cranefield, Am. J. Med. 37, 670 (1964).
W. Trautwein, Pharmac. Rev. 15, 277 (1963).
E. E. Carmeliet, Arch. int. Physiol. 73, 171 (1965).
N. Toda, Circ. Res. 27, 45 (1970).
B. F. Hoffman, in: Digitalis ( Grane and Stratton, New York 1969 ), p. 93.
R. Kaufmann and V. Theophile, Pflügers Arch. 297, 174 (1967).
A. S. Harris, Am. Heart J. 77, 797 (1966).
J. Griffiths and F. Leung, Am. Heart J. 82, 171 (1971).
J. A. Abildskov and M. J. Burgess, J. Electrocardiol. 4, 87 (1971).
C. McBrooks, B. F. Hoffman, E. E. Suckling and O. Orias, Excitability of the Heart ( Grane and Stratton, New York 1955 ).
M. R. Rosen, H. Gelband and B. F. Hoffman, Circulation 44 (Suppl. 2,) 84 (1971).
G. F. Ferrier and C. Mendez, Fed. Proc. 31, 314 (1972).
J. H. SaunderS and G. K. Moe, Fed. Proc. 31, 314 (1972).
K. Matsuda, T. Hoshi and S. Kameyama, Jap. J. Physiol. 9, 419 (1959).
K. Matsuda, B. F. Hoffman, C. M. Ellner, M. Katz and C. McC. Brooks, Proc. XIX Int. Physiol. Congr. Montreal (1953), p. 596.
H. C. Strauss, J. T. Bigger, Jr., and B. F. Hoffman, Circ. Res. 26, 661 (1970).
R. Kaufmann, Pflügers Arch. 294, 235 (1966).
R. A. Jensen and B. G. Katzung, Nature 217, 961 (1968).
R. Lazzara and J. L. Abelleira, Fed. Proc. 31, 387 (1972).
P. L. Friedman, A. L. Wit and B. F. Hoffman, Buu. N. Y. Acad. Med. 48, 1037 (1972)
W. Trautwein and D. G. Kassebaum, J. Gen. Physiol. 45, 317 (1961).
J. C. Pamintuan, L. S. Dreifus and Y. Watanabe, Am. J. Cardiol. 26, 512 (1970).
H. Antoni, Arch. Pharmak. 269, 172 (1971).
A. L. Hodgkin and A. F. Huxley, J. Physiol. Lond. 117, 500 (1952).
D. H. Singer, R. Lazzara and B. F. Hoffman, Circ. Res. 21, 537 (1967).
R. T. Van Dam, E. M. Moore and B. F. Hoffman, Am. J. Physiol. 204, 1133 (1963).
S. Weidmann, J. Physiol., Lond. 127, 213 (1955).
J. T. Bigger, Jr., in: Lidocaine in the Treatment of Ventricular Arrhythmias (E. & S. Livingston, Edinburgh. 1971 ), p. 66.
J. T. Bigger, Jr., and W. J. Mandel, J. Clin. Invest. 49, 63 (1970).
J. T. Bigger, Jr., A. L. Bassett and B. F. Hoffman, Cir. Res. 22, 331 (1968).
B. F. Hoffman, in: The Myocardial Cell: Structure, Function and Modification by Cardiac Drugs (University of Pennsylvania, Philadelphia, Pa. 1966 ), p. 251.
S. Weidmann, J. Physiol. Lond. 129, 568 (1955).
A. M. Shanes, W. H. Freygang, H. Grundfest and E. Amatniek, J. gen. Physiol. 42, 793 (1959).
E. A. Johnson, J. Pharmac. exp. Ther. 117, 237 (1956).
B. F. Hoffman, An. Acad. Brasil Cienc. 29, 365 (1958).
E. M. Vaughan Williams, Br. J. Pharmac. 13, 276 (1958).
M. Prinzmetal, K. Ishikawa, H. Oishi, E. Ozkan,, J. Wakayama and J. M. Baines, J. Pharmac. exp. Ther. 157, 659 (1967).
D. H. Singer, H. C. Strauss and B. F. Hoffman, Bull. N. Y. Acad. Med. 43, 1194 (1967).
G. E. Freud, Circulation 44 (Suppl. 2 ), 72 (1971).
S. Bellet, Clinical Disorders of the Heart Beat ( Lea Febiger, Philadelphia 1971 ).
D. H. Singer, T. N. James, P. D. Harris, J. R. Malm and B. F. Hoffman, Circulation 36 (Suppl. 2), 239 (1967).
R. Parameswaran, R. E. Teneick and D. H. Singer, Circulation 44 (Suppl. 2), 84 (1971).
W. Trautwein, V. Gottstein and J. Dudel, Pflügers Arch. 260, 40 (1954).
B. J. Scherlag and J. Rodriguez, Fed. Proc. 31, 387 (1972).
L. E. Solberg, D. H. Singer and R. E. Teneick, Fed. Proc. 31, 387 (1972).
H. Reuter, Pflügers Arch. 287, 357 (1966).
H. Reuter, J. Physiol. Lond. 192, 479 (1967).
O. Rougier, G. Vassort, D. Garnier, Y. M. Gargouil and E. Corabgeuf, Pflügers Arch. 309, 70 (1996).
P. F. Cranefield, A. L. Wit and B. F. Hoffman, J. gen. Physiol. 59, 227 (1972).
D. Mascher, Pflügers Arch. 317, 359 (1970).
E. Carmeliet and J. Vereecke, Pflügers Arch. 313, 300 (1969).
A. J. Pappano, Gire. Res. 27, 379 (1970).
D. Mascher, Pflügers Arch. 323, 284 (1971).
J. Vereecke and E. Carmeliet, Pflügers Arch. 322, 60 (1971).
J. Vereecke and E. Carmeliet, Pflügers Arch. 322, 73 (1971).
E. A. Johnson and M. Lieberman, Ann. Rev. Physiol. 33, 479 (1971).
P. F. Cranefield, H. O. Klein and B. F. Hoffman, Circ. Res 28, 199 (1971).
P. F. Cranefield and B. F. Hoffman, Circ. Res. 28, 220 (1971).
A. L. Wit, B. F. Hoffman and P. F. Cranefield, Circ. Res. 30, 1 (1972).
A. L. Wit, P. F. Cranefield and B. F. Hoffman, Circ. Res. 30 1 1 (1972).
S. W. Wissner, Circulation 44 (Suppl. 2), 101 (1971).
P. F. Cranefield, A. L. Wit and B. F. Hoffman, Circulation, in press.
A. L. Bassett and H. Gelband, unpublished observations.
R. J. Myerburg, J. W. Stewart and B. F. Hoffman, Circ. Res. 26, 361 (1970).
R. J. Myerburg, H. Gelband and B. F. Hoffman, Circ. Res, 28, 136 (1971).
L. A. Harrison, J. H. Wittig and A. G. Wallace, Circulation 44 (Suppl. 2), 85 (1971).
J. H. Wittig, L. A. Harrison and A. G. Wallace, Circulation 44, (Suppl. 2 ) 85 (1971).
M. R. Rosen, C. Merker, H. Gelband and B. F. Hoffman, Fed. Proc. 31, 524 (1972).
R. Lazzara, B. K. Yeh and P. Samet, Circulation 44 (Suppl. 2), 73 (1971).
R. J. Myerburg, K. Nilsson and H. Gelband, Circ. Res. 30, 217 (1972).
R. J. Myerburg, K. Nilsson and C. A. Castillo. Fed. Proc. 31, 313 (1972).
G. J. Anderson, K. Greenspan, J. B. Bandura and C. Fisch, Circ. Res. 27, 691 (1970).
R. J. Myerburg and K. Nilsson, Circulation 44 (Suppl. 2), 73 (1971).
M. S. Spach, R. C. Barr, G. S. Serwer, E. A. Johnson and J. M. Kootsey, Circ. Res. 29, 4 (1971).
B. I. Sasyniuck and C. Mendez, Circ. Res. 28, 3 (1971).
J. R. Wennemark and V. J. Ruesta, J. Electrocardiol. 4, 50 (1971).
A. Paes De Carvalho, B. F. Hoffman and M. De Paula Carvalho, J. gen. Physiol. 54, 607 (1969).
H. C. Strauss and J. T. Bigger, Jr., Circulation 42 (Suppl. 3), 68 (1970).
H. C. Strauss and J. T. Bigger, Jr., Circ. Res. 31, 490 (1972).
J. Han, A. M. Malozzi and G. K. Moe, Circ. Res. 22, 355 (1968).
F. I. M. Bonks, L. N. Bouman and F. J. G. Schopman, Circ. Res. 29, 704 (1971).
A. L. Wit and A. L. Bassett, Fed. Proc. 31, 523 (1972).
C. Mendez and G. K. Moe, Circ. Res. 19, 378 (1966).
D. Scherf and J. Cohen, The Atrioventricular Node and Selected Cardiac Arrhythmias ( Grune and Stratton, New York 1964 ).
J. T. Bigger, Jr.,and B, N. Goldreyer, Circulation 42, 673 (1970).
B. N. Goldreyer and J. T. Bigger, Jr., Circulation 43, 15 (1971).
M. E. J Anse, J. L. Van Capelle, G. E. Freud and D. Durrer, Circ. Res. 28, 403 (1971)
A. L. Wit, B. N. Goldreyer and A. N. Damato, Circulation 43, 862 (1971).
M. R. Rosen, H. Gelband and B. F. Hoffman, Fed. Proc. 30, 668 (1971).
M. R. Rosen, H. Gelband and B. F. Hoffman, Circ. Res. 30, 575 (1972).
M. R. Rosen, H. Gelband and B. F. Hoffman, Pharmacologist 13, 224 (1971).
M. R. Rosen, H. Gelband and B. F. Hoffman, Circulation 46, 528 (1972).
B. F. Hoffman, V. P. Butler, Jr., H. Gelband and M. R. Rosen, Fed. Proc. 30, 393 (1971).
K. Peper and W. Trautwein, Pflügers Arch. 296, 328 (1967).
G. Vassort, O. Rougier, D. Garnier, M. P. Sauviat, E. Corabceuf and Y. M. Gargouil, Pflügers Arch. 309, 70 (1969).
O. Hauswirth, D. Noble and R. W. Tsien, Science 162, 916 (1968).
T. Sano, Y. Iida and M. Hiraoka, Jap. J. Physiol. 20, 155 (1970).
M. Kohlhardt, B. Bauer, H. Krause and A. Fleckenstein, Experientia 28, 288 (1972).
J. R. Schmidt and C. Hanna, J. Pharmac. exp. Ther. 156, 331 (1967).
D. H. Schmidt and V. P. Butler, Jr., J. Clin. Invest. 50, 866 (1971).
D. H. Schmidt and V. P. Butler, Jr., J. Clin; Invest. 50, 1738 (1971).
F. Ciofalo and H. Ashe, Life Sci. (1) 10, 341 (1971).
W. J. Mandel, V. P. Butler and J. T. Bigger, Jr., Fed. Proc. 29, 739 (1970).
W. J. Mandel, J. T. Bigger, Jr., and V. P. Butler, Jr., J. din. Invest. 51, 1378 (1972).
B. K. Yeh, Fed. Proc. 31, 348 (1972).
B. K. Yeh and R. Lazzara, Pharmacologist 13, 224 (1971).
B. K. Yeh, N. T. De Guzman and T. Pinakatt, Clin. Res. 30, 405 (1972),
B. N. Singh and E. M. Vaughan Williams, Circ. Res. 29, 286 (1971).
A. L. Bassett, J. T. Bigger, Jr., and B. F. Hoffman, J. Pharmac. exp. Ther. 173, 336 (1970).
H. J. Zeft, R. E. Whalen, N. B. Ratliff, Jr., R. D. DAvenport, Jr., and H. D. McIintosH, J. Pharmac. exp. Ther. 162, 80 (1968).
H. C. Strauss, J. T. Bigger, Jr., A. L. Bassett and B. F. Hoffman, Circ. Res. 23, 463 (1968).
R. A. Jensen and B. G. Katzung, Circ. Res. 26, 17 (1970).
B. G. Katzung and R. A. Jensen, Am. Heart J. 80, 80 (1970).
A. R. Cox and T. C. West, J. Pharmac. exp. Ther. 131, 212 (1961).
Y. Watanabe, L. S. DreifuS and W. Lkoff, Am. J. Cardiol 12, 702 (1963).
B. Surawicz, Prog. Cardiovasc. Dis. 8, 364 (1966).
L. S. Dreifus and Y. Watanabe, Am. Heart J. 80, 709 (1970).
C. H. Hockman, H. P. Mauck and N. Chu, Am. Heart J. 74, 256 (1967).
A. Raines, B. Levitt, F. G. Standaert and Y. J. Sohn, Eur. J. Pharmac. 11, 293 (1970).
A. Raines and B. Levitt, Arch. int. Pharmacodyn. 172, 435 (1968).
R. A. Gillis, J. McClellan, T. S. Sauer and F. G. Standaert, J. Pharmac. exp. Ther. 179, 599 (1971).
J. Roberts, Proc. Soc. exp. Biol. Med. 134, 274 (1970).
L. D. Davis and J. V. Temte, Circ. Res. 24, 639 (1969).
J. T. Bigger, Jr., and W. J. Mandel, J. Pharmac. exp. Ther. 172, 239 (1970).
W. J. Mandel and J. T. Bigger, Jr., J. Pharmac. exp. Ther. 178, 81 (1971).
J. T. Bigger, Jr., in: Lidocaine in the Treatment of Ventricular Arrhythmias (E.& S. Livingston, Edinburgh 1971 ), p. 43.
B. N. Singh, in: Lidocaine in the Treatment of Ventricular Arrhythmias (E.& S. Livingston, Edinburgh 1971 ), p. 59.
M. F. Arnsdorf and J. T. Bigger, Jr., Circulation 44 (Suppl. 2), 136 (1971).
M. F. Arnsdorf and J. T. Bigger, Jr., J. Clin. Invest. 51, 2252 (1972).
L. Gould, R. F. GomprechT and M. Zahir, Br. Heart J. 33, 101 (1971).
P. K. Das and J. R. Parratt, Br. J. Pharmac. 41, 437 (1971).
M. R. Rosen and H. Gelband, Am. Heart J. 81, 428 (1971).
B. F. Hoffman and D. H. Singer, Ann. N. Y. Acad. Sci. 139, 914 (19673.
M. R. Rosen, H. Gelband and B. F. Hoffamn, J. Pharmac. exp. Ther. 179, 586 (1971).
T. Sano, Symposium on Cardiac Arrhythmias ( AB Astra: Sôldertâje, Sweden 1970 ), p. 25.
W. Trautwein, Sympsium on Cardiac Arrhytmias ( AB Astra: Soldertalje, Sweden 1970 ), p. 53.
E. M. Vaughan Williams, Symposium on Cardiac Arrhythmias ( AB Astra: Soder- talje, Sweden 1970 ), p. 449.
B. N. Singh and E. M. Vaughan Williams, Br. J. Pharmac. 44, 1 (1972).
E. M. Vaughan Williams, in: Int. Symposium on the Coronary Circulation and Energetics of the Myocardium (Karger, Basel, New York 1967 ), p. 118.
A. N. Dohadwalla, A.S. Freedberg and E. M. Vaughan WilliamS, Br. J. Pharmac. 36, 257 (1969).
B. N. Singh and E. M. Vaughan Williams, Br. J. Pharmac. 38, 749 (1970).
B. N. Singh and E. M. Vaughan Williams, Br. J. Pharmac. 43, 10 (1971).
E. M. Vaughan Williams, Am. J. Cardiol. 18, 399 (1966).
B. N. Singh and E. M. Vaughan Williams, Br. J. Pharmac. 39, 675 (1970).
B. N. Singh and E. M. Vaughan Williams, Br. J. Pharmac. 39, 657 (1970).
B. N. Singh and E. M. Vaughan Williams, Cardiovasc. Res. 6, 109 (1972).
J. GY. Papp and E. M. Vaughan Williams, Br. J. Pharmac. 37, 391 (1969).
E. Corabœuf and G. Vassort, J. ElectrocardioL 1, 19 (1968).
P. Somani and D. L. Watson, J. Pharmac. exp. Ther. 164, 317 (1968).
M. L. Wagner, R. Lazzara, R. M. Weiss and B. F. Hoffman, Circ. Res. 18, 502 (1965).
T. Sano and S. Yamagishi, Circ. Res. 16, 423 (1965).
R. W. Childers, J. Merideth and G. K. Moe, Circ. Res. 22, 363 (1968).
P. M. Hogan and L. D. Davis, Circ. Res. 23, 387 (1968).
P. M. Hogan and L. D. Davis, Circ. Res. 28, 62 (1971).
E. M. Vaughan Williams, in: Lidocaine in the Treatment of Ventricular Arrhythmias (E. S. Livingston, Edinburgh 1971 ), p. 2.
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Bassett, A.L., Wit, A.L. (1973). Recent Advances in Electrophysiology of Antiarrhythmic Drugs. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques, vol 17. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7084-9_2
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